球笼式万向联轴器试验设计与性能分析

实际使用过程中发现：转速、摆角、扭矩是导致球笼式同步万向联轴器本体发热量过大、寿命降低的主要原因.本文采用正交试验法对球笼式同步万向联轴器的性能进行测试,利用极差分析法对正交试验结果进行分析.结果表明对球笼本体发热量大小的影响程度依次是转速、摆角、扭矩,最后对球笼式万向联轴器的设计提出了建议.     

N-乙酰氨基葡萄糖对绛红小单孢菌合成庆大霉素的影响

研究了N-乙酰氨基葡萄糖对绛红小单孢菌产素的影响,实验探索了N-乙酰氨基葡萄糖添加工艺,在250mL摇瓶发酵过程中培养48h,60h分别添加0.05%,0.15%N-乙酰氨基葡萄糖可使庆大霉素生测效价达2 030U/mL,较对照1 228U/mL提高了65%以上(三次平均基本一致);5L发酵罐试产三批次发酵终结,生测效价平均为1 727U/mL(厡工艺1 097U/mL)提高了57%,效果十分明显.同时测定了发酵过程中菌体代谢各种参数的变化,证明了N-乙酰氨基葡萄糖在绛红小单孢菌生物合成中的促进作用.本方法操作简单,基本不改变原工艺,生产成本低廉,对提高庆大霉素产量效果非常明显.     

Liver X receptors in cardiovascular and metabolic disease

Liver X receptors (LXRs) α and β are nuclear oxysterol receptors and metabolic sensors initially found to regulate cholesterol metabolism and lipid biosynthesis. Recent studies have elucidated the importance of LXR in the development of cardiovascular diseases and metabolic disorders. LXR agonists prevent development of atherosclerosis by modulation of metabolic as well as inflammatory gene expression in rodent models. Moreover, LXR activation inhibits hepatic gluconeogenesis and lowers serum glucose levels, indicating possible application of LXR activation in the treatment of diabetes mellitus. However, first-generation LXR agonists elevate hepatic and serum trigylceride levels, making subtype-specific agonists and selective LXR modulators rather than unselective LXR agonists a potential pharmacological strategy. This review summarizes the multiple physiological and pathophysiological implications of LXRs and observations that identify LXRs as potential targets for therapeutic interventions in human cardiovascular and metabolic disease. Received 30 August 2005; received after revision 10 October 2005; accepted 4 November 2005     

基于灰色理论的设备状态预测

针对一般GM(1,1)多步预测方法的不足,提出了一种基于代谢递补GM(1,1)的状态预测方法.该方法首先对原始信号进行预处理,再通过递补思想进行多步预测,然后利用更新数据进行代谢预测,最后计算设备状态的预测值与真实值误差,根据预测值的趋势判断设备的未来状态.实例分析结果表明,该方法所需数据样本少且数据训练时间短,后八步的预测精度可满足工程精度,能有效地应用于设备的中长期在线状态预测.     

硫酸盐还原菌及其在工业和矿山废水治理中的应用

介绍了硫酸盐还原菌（SRB）的分类、代谢机理和生长影响因子，并就SRB在工业废水和酸性矿山废水（AMD）厌氧生物修复方面的研究进展进行了综述，最后提出这方面研究尚存在的问题。     

硝化颗粒污泥的成长特性

研究了649μm、1 171μm和1 571μm三个粒径、不同初始生物量的硝化颗粒污泥90 d内的硝化性能,发现颗粒比增长速率μd、生物量比增长速率μg的变化均随粒径增大而减小.其成因在于硝化颗粒污泥内部生态环境、菌群和生物量随污泥粒径增长发生了变化,可以用引入比代谢速率后的生物量变化模型来描述这种变化.     

代谢工程和作物改良

基因组学和植物生理生化是通过基因工程改良作物的基础 .借助于这些基础研究 ,通过基因工程调控代谢途径 ,提高了油菜籽粒中的油脂含量和拟南芥种子中的维生素 E活性 ,使水稻的胚乳中能合成维生素A原 ,增加了水稻在碱性土壤中吸收铁的能力 ,展示了代谢工程在定向改良作物中的应用前景     

棕色田鼠静止代谢率的比较研究

以棕色田鼠的耗氧量为指标，探讨了雌（哺乳和非哺乳），雄棕色田鼠能量代谢的特征，结果表明，在热中性区（20－25．0℃），棕色田鼠静止代谢率为2．4601moO2/g/h，是期望值的175．70％，其中哺乳雄鼠为2．5843mlO2/g/h，是期望值的190．68％，非哺乳雌鼠为2．3477mlO2/g/h，是期望值的164．92％，雄鼠为2．3949mlO2/g/h，是期望值的165．37％，棕色田鼠在22．5℃时的平均热传导为0．1797mlO2/g/h/℃，棕色田鼠较高的RMR（繁殖期更高），稍高的热传导率，是对生存环境的适应性反应。     

Bow-tie topological features of metabolic networks and the functional significance

Exploring the structural topology of genome-based large-scale metabolic network is essential for in- vestigating possible relations between structure and functionality.Visualization would be helpful for obtaining immediate information about structural organization.In this work,metabolic networks of 75 organisms were investigated from a topological point of view.A spread bow-tie model was proposed to give a clear visualization of the bow-tie structure for metabolic networks.The revealed topological pattern helps to design more efficient algorithm specifically for metabolic networks.This coarse- grained graph also visualizes the vulnerable connections in the network,and thus could have important implication for disease studies and drug target identifications.In addition,analysis on the reciprocal links and main cores in the GSC part of bow-tie also reveals that the bow-tie structure of metabolic networks has its own intrinsic and significant features which are significantly different from those of random networks.     

大众艺术体操锻炼对中年女性预防代谢综合征的作用研究

研究结合中年女性生理特点,通过两年的大众艺术体操锻炼实验,分析健康中年女性的体质指数、心率、血压、血糖、血脂等与代谢综合征密切相关的生理生化指标在实验前后的变化,探讨长期参加大众艺术体操锻炼对代谢综合征的预防作用。结果表明两年的大众艺术体操锻炼使健康中年女性保持原正常的BMI、HR、DBP、BS、TG、TC、HDL-C、LDL-C水平,降低了SBP水平,有效减缓了各项指标向不利于健康方向发展的趋势,对代谢综合征的预防起到一定的作用。