一种简化的医学图像中轴提取算法

针对模拟整形手术中外表皮与模型分割问题,提出一种简化的基于活动窗的中轴提取方法.该方法充分利用分割区域的形状先验,将M-Reps方法简化,在保证分割椭圆环状物体精度的同时,提高了效率.实验结果表明,中轴提取方法在模拟整形手术的外表皮与模型分割中具有高效和可靠性.     

Cell lineage and cell migration in the developing cerebral cortex

Summary Modern techniques which trace lineages of individual progenitor cells have provided some clues about the processes that determine cell fate in the brain, and have also given us some information about migratory patterns of clonally related cells. In many parts of the central nervous system, progenitors are multipotent; single clones can contain multiple neuronal types or even mixtures of neurons and glia. In addition, one can observe a wide distribution in clone size, even when marking is done in a narrow time window. This suggests that progenitor cells may be fairly plastic and responsive to environmental signals. In the developing cortex, clonally related cells are initially grouped near each other, as in the retina and tectum. However, the subsequent migration of these cells from the ventricular zone to the cortex along glial fibers is accompanied by a progressive dispersion of clonally related neurons.     

中轴生成算法和自适应有限元模糊控制(Ⅱ)--基于中轴的自适应有限元模糊控制策略与实施

在任意形体中轴生成算法结果的基础上，根据中轴半径及其变化，建立并实现了h型自适应有限元模糊控制机制。进行的数值模拟实例表明，采用本文方法，仅需一次计算就能达到要求的计算精度，从而可以大大提高自适应有限元前置处理的效率。     

正常状态下黑线仓鼠脑内c-fos的基础表达

目的：研究正常状态下黑线仓鼠脑内前脑皮层、海马和下丘脑区c-fos的基础表达。方法：采用免疫组织化学方法（SABC）检测c-fos蛋白在黑线仓前脑皮层、海马和下丘脑区的表达,以昆明品系小鼠为对照,建立足底电击急性应激小鼠模型。结果：正常生活状态下黑线仓鼠脑内前脑皮层、海马和下丘脑区c-fos蛋白广泛表达;其中海马CA1和CA3区c-fos阳性神经元相对数量较少,海马DG区、前脑皮层和下丘脑区c-fos阳性神经元相对数量较多;与正常小鼠相比,前脑皮层c-fos阳性神经元显著增多（P〈0.01）。应激小鼠各脑区c-fos阳性神经元数量明显增多,与正常小鼠比较有统计学显著差异（P〈0.05,P〈0.01）。各脑区c-fos阳性神经元平均目标灰度值结果类似。结论：正常状态下黑线仓鼠脑内c-fos蛋白的表达可能与动物的行为活动和内分泌、空间认知功能以及复杂运动的调控密切相关。     

羊毛微细结构与性质关系的研讨

本文采用电子显微镜技术、等离子体刻蚀、DSC 分析技术、皮质细胞分离技术及 X 射线衍射方法等近代测试手段,对地毯用阿根廷毛和中国浙江毛的微结构进行了较深入的研究。结果表明:这两种不同品种的毛纤维在微结构和性质上都存在着差异。阿根廷毛的鳞片大而厚,表面结构较致密,鳞片的纵向密度较稀,张角较大,径向的重叠数较多,鳞片间呈镶嵌连接,皮质层大部分由正皮质细胞组成,少量副皮质细胞呈环形分布在外围;而浙江毛的鳞片较薄,纵向排列密度较密,与毛干包覆得较紧,鳞片间呈对接连接,正、副皮质细胞为双边分布;两种毛的氨基酸种类相同,但阿根廷毛的极性基团略高,含硫量较低。在性质方面,阿根廷毛的耐稀碱性较强,碱液浓度增至一定值后、损伤反而比浙江毛严重。阿根廷毛的耐酸性较差,上染速率与平衡上染率也较低,但初始上染温度较高。耐生物酶性比浙江毛差,热分解温度亦较低。此外,文章中还论述了羊毛结构与性质间的相互关系以及对后整理的影响。     

高级神经活动特征与灵敏协调反应的关系及应用

通过对运动员高级神经活动特征和灵敏协调反应的实验分析,得出了它们之间的正相关关系,并应用于飞行学员的飞行训练选材。对诸类与灵敏协调性有关的专业人员的选材提供了理论依据。     

Cleavage of des-Arg9-bradykinin by angiotensin I-converting enzyme from pig kidney cortex

Summary Fast and very slow hydrolyses of des-Arg⁹-bradykinin and angiotensin II by angiotensin I-converting enzyme were detected by high performance liquid chromatography. The Michaelis constants of the enzyme, K_m values, for des-Arg⁹-bradykinin and bradykinin were found to be 0.24 mM and 4.4 M, and the maximum velocities, V_max values (mol·min^–1·mg protein^–1) for these compounds to be 3.24 and 0.34, respectively. The enzyme also hydrolyzed Z-Gly-Pro-Gly-Gly-Pro-Ala to a tripeptide that was identified as dansyl-Gly-Pro-Ala by TLC on polyamide. These observations show that the enzyme hydrolyzes the peptides at the bond before the prolyl residue in the penultimate position.Acknowledgments. We thank Dr Kinzo Nagasawa of Kitasato University for encouragement in this work and Dr Ervin G. Erdös, University of Texas, Health Science Center, Dallas, for valuable discussion and suggestions.Abbreviations used: Z, carbobenzoxy; Bz, benzoyl; ACE, angiotensin I-converting enzyme; BK, bradykinin; HPLC, high performance liquid chromatography.     

Sparse representation of global features of visual images in human primary visual cortex: Evidence from fMRI

In fMRI experiments on object representation in visual cortex, we designed two types of stimuli： one is the gray face image and its line drawing, and the other is the illusion and its corresponding completed illusion. Both of them have the same global features with different minute details so that the results of fMRI experiments can be compared with each other. The first kind of visual stimuli was used in a block design fMRI experiment, and the second was used in an event-related fMRI experiment. Comparing and analyzing interesting visual cortex activity patterns and blood oxygenation level dependent （BOLD）- fMRI signal, we obtained results to show some invariance of global features of visual images. A plausible explanation about the invariant mechanism is related with the cooperation of synchronized response to the global features of the visual image with a feedback of shape perception from higher cortex to cortex V1, namely the integration of global features and embodiment of sparse representation and distributed population code.     

Shape Recognition and Retrieval Based on Edit Distance and Dynamic Programming

An important aim in pattern recognition is to cluster the given shapes. This paper presents a shape recognition and retrieval algorithm. The algorithm first extracts the skeletal features using the medial axis transform. Then, the features are transformed into a string of symbols with the similarity among those symbols computed based on the edit distance. Finally, the shapes are identified using dynamic programming. Two public datasets are analyzed to demonstrate that the present approach is better than previous approaches.     

小白鼠肾上腺摘除对其机体应激能力的影响

实验表明，切除小白鼠双侧肾上腺后，一周内，小白鼠体重下降，死亡率较高；去肾上腺的小白鼠在冰水中的游泳时间较对照组短，而恢复时间却比对照组的长，反映了去除肾上腺的小白鼠的应激能力比对照组减弱。