孕妇碘营养不足对母儿的影响

目的:通过随机抽取350例2010年3月—2011年3月在本院围产门诊进行尿碘检测的孕妇,探讨妊娠期妇女碘营养状况,为本地区缺碘孕妇孕期补碘的剂量、时间的掌握提供依据,以指导围产期妇女的保健。方法:采用尿碘半定量目测法测定孕妇尿碘含量,研究孕妇妊娠早、中、晚期及不同年龄阶段尿碘含量的变化。结果:孕妇在不同孕期、不同年龄阶段碘营养状况有差异。结论:妊娠初期及中期应注意碘元素的补充。     

Understanding the importance of selenium and selenoproteins in muscle function

Selenium is an essential trace element. In cattle, selenium deficiency causes dysfunction of various organs, including skeletal and cardiac muscles. In humans as well, lack of selenium is associated with many disorders, but despite accumulation of clinical reports, muscle diseases are not generally considered on the list. The goal of this review is to establish the connection between clinical observations and the most recent advances obtained in selenium biology. Recent results about a possible role of selenium-containing proteins in muscle formation and repair have been collected. Selenoprotein N is the first selenoprotein linked to genetic disorders consisting of different forms of congenital muscular dystrophies. Understanding the muscle disorders associated with selenium deficiency or selenoprotein N dysfunction is an essential step in defining the causes of the disease and obtaining a better comprehension of the mechanisms involved in muscle formation and maintenance. Received 13 July 2005; received after revision 9 September 2005; accepted 4 October 2005     

广西地区1641名献血员铁营养状况研究

对广西南宁、柳州、桂林、玉林四市血站１６４１名献血员进行血红蛋白、红细胞游离原卟啉、血清铁蛋白等铁指标测定，结果１０５０名男献血员及５９１名女献血员铁缺乏症患病率分别为３８．６７％及４５．８５％，其中缺铁性贫血患病率分别为２２．１％及３８．９２％；献血员铁缺乏症与年平均献血量关系较为密切。表明广西地区献血员铁缺乏症患病率较高，程度较为严重。     

关于亚纯函数的亏量与特征函数

设f(z)为开平面上的有穷级亚纯函数,如果som form n=∑δ(a,f)=2,则有如下结果成立。(ⅰ)当δ(∞,f)=1时,对所有正整数k有 T(r,f)～T(r,f~(k)),r→∞。(ⅱ)当δ(∞,f)=0时 T(r,f~(k))～(k 1)T(r,f),r→∞。     

OZAWA定理的推广

本文得到了关于亚纯函数唯一性的一个结果,推广并改进了Ozawa定理。     

新的上可嵌入图类

图C的C-划分指：C的一个顶点划分{V1，V2，…，V4}使得每个C[Vi]为多重完全图（l≤i≤k）。证明了如下结果：设C为连通图，且对任意v∈V(C)，dc(v)≡1(mod4)。若C的顶点集存在一个C-划分{V1，V2，…，V4}使得对每个1≤i≤k，|Vi|≥4，且≡0（mod4），则C是上可嵌入的，另外，联系着图的点的度和其它条件，推广和深化了目前有关这方面的一些结果，给出了另一些上可嵌入图类。     

Triplet repeat disorders: discussion of molecular mechanisms

Comparison of the growing number of disorders known to be associated with triplet repeat expansions reveals both common features and a diversity of molecular pathways. Despite significant progress towards the characterization of proteins coded by the mutant genes, the complex nature of these disorders requires identification of all molecular components of the triplet repeat pathways. In this brief review we will discuss recent progress in determining the molecular mechanisms of disorders with unstable trinucleotide mutations. Received 13 January 1999; received after revision 8 March 1999; accepted 9 March 1999     

Alopecia induced in young mice by exposure to excess dietary zinc

Summary Second generation mice were exposed to normal (50 ppm, Group I) or excess (2000 ppm, Group II) zinc in the maternal diet during gestation and lactation, then weaned and continued on the mother's diet until sacrifice at 8 weeks. Tibia zinc reflected dietary intake. Group II had reduced plasma copper, body weight, and hematocrit; the second coat of hair appeared late and was lighter in color than Group I, possibly as an effect of copper and pigmentation development and hair growth.     

Neurobiology and neuroimmunology of Tourette’s syndrome: an update

Tourettes syndrome is a childhood-onset neuropsychiatric disorder characterized by the presence of both multiple motor and vocal tics. While the pathogenesis at a molecular and cellular level remains unknown, structural and functional neuroimaging studies point to the involvement of the basal ganglia and related cortico-striato-thalamo-cortical circuits as the neuroanatomical site for Tourettes syndrome. Moreover, Tourettes syndrome has a strong genetic component, and considerable progress has been made in understanding the mode of transmission and in identifying potential genomic loci. Summaries of recent findings in these areas will be reviewed, followed by a critical overview of findings both supporting and challenging the proposed autoimmune hypothesis of Tourettes syndrome. We conclude that Tourettes syndrome is a heterogeneous disorder, and that immune factors may indeed be involved in some patients.Received 12 August 2003; received after revision 8 October 2003; accepted 31 October 2003     

Human mitochondrial tRNAs in health and disease

The human mitochondrial genome encodes 13 proteins, all subunits of the respiratory chain complexes and thus involved in energy metabolism. These genes are translated by 22 transfer RNAs (tRNAs), also encoded by the mitochondrial genome, which form the minimal set required for reading all codons. Human mitochondrial tRNAs gained interest with the rapid discovery of correlations between point mutations in their genes and various neuromuscular and neurodegenerative disorders. In this review, emerging fundamental knowledge on the structure/function relationships of these particular tRNAs and an overview of the large variety of mechanisms within translation, affected by mutations, are summarized. Also, initial results on wide-ranging molecular consequences of mutations outside the frame of mitochondrial translation are highlighted. While knowledge of mitochondrial tRNAs in both health and disease increases, deciphering the intricate network of events leading different genotypes to the variety of phenotypes requires further investigation using adapted model systems.Received 3 December 2002; received after revision 14 January 2003; accepted 27 January 2003