全文获取类型
收费全文 | 22845篇 |
免费 | 844篇 |
国内免费 | 1316篇 |
专业分类
系统科学 | 1133篇 |
丛书文集 | 652篇 |
教育与普及 | 244篇 |
理论与方法论 | 67篇 |
现状及发展 | 204篇 |
综合类 | 22678篇 |
自然研究 | 27篇 |
出版年
2024年 | 74篇 |
2023年 | 152篇 |
2022年 | 270篇 |
2021年 | 306篇 |
2020年 | 309篇 |
2019年 | 277篇 |
2018年 | 243篇 |
2017年 | 400篇 |
2016年 | 403篇 |
2015年 | 598篇 |
2014年 | 994篇 |
2013年 | 771篇 |
2012年 | 1280篇 |
2011年 | 1372篇 |
2010年 | 947篇 |
2009年 | 1209篇 |
2008年 | 1199篇 |
2007年 | 1666篇 |
2006年 | 1562篇 |
2005年 | 1385篇 |
2004年 | 1262篇 |
2003年 | 1083篇 |
2002年 | 941篇 |
2001年 | 839篇 |
2000年 | 798篇 |
1999年 | 643篇 |
1998年 | 579篇 |
1997年 | 539篇 |
1996年 | 439篇 |
1995年 | 368篇 |
1994年 | 356篇 |
1993年 | 342篇 |
1992年 | 302篇 |
1991年 | 262篇 |
1990年 | 242篇 |
1989年 | 220篇 |
1988年 | 174篇 |
1987年 | 120篇 |
1986年 | 53篇 |
1985年 | 14篇 |
1984年 | 3篇 |
1981年 | 3篇 |
1955年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
911.
Ying Qin Guozhi Cao Zhi Su 《系统科学与信息学报》2008,6(2):109-117
Environmental problem is one of complicated social problems. According to the level of corporate environmental management, there are many influential factors, and their relations are also complicated. In this paper, we analyzed influential factors of corporate environmental management through consultation of experts. And based on the analysis, we applied interpretative structural modeling(ISM) to classify 13 influential factors into 3 levels. We hope it will be useful for the subsequent research and evaluation of corporate environmental management level. 相似文献
912.
Zinc binding to peptide analogs of the structural zinc site in alcohol dehydrogenase: Implications for an entatic state 总被引:1,自引:0,他引:1
Bergman T Zhang K Palmberg C Jörnvall H Auld DS 《Cellular and molecular life sciences : CMLS》2008,65(24):4019-4027
Zinc binding to the peptide replica and analogs to residues 93–115 of horse liver alcohol dehydrogenase (ADH) was examined
by competition of the peptides and the chromophoric chelator 4-(2- pyridylazo)resorcinol for zinc and X-ray absorption fine
structure analysis of the zinc ligands. In the enzyme, zinc is coordinated by four Cys residues. In the peptide replica, zinc
is bound to three Cys and one His residue. A four-Cys zinc coordination is observed only when His is removed, leading to increased
zinc stability. ADH crystal structures reveal that the ε-amino group of the conserved residue Lys323 is within H-bond distance
of the backbone amide oxygens of residues 103, 105 and 108, likely stabilizing the zinc coordination in the enzyme. The peptide
data thus indicate structural strain and increased energy in the zinc-binding site in the protein, characteristic of an entatic
state, implying a functional nature for this zinc site.
Received 3 July 2008; received after revision 11 August 2008; accepted 1 September 2008 相似文献
913.
对动态投入产出系统消费跟踪模型,按实际消费要求进行了修正,同时引入了生产过程优化目标函数,提出了动态投入产出生产策略的优化问题,进而得出了求解方法并给出了优化的生产结构调整策略. 相似文献
914.
模糊数学在高等级公路路面选型中的应用 总被引:6,自引:0,他引:6
应用模糊数学的多层次综合评判法对路面选型问题进行了研究,提出了路面选型的评价体系,并应用专家评分法确定了各因素的权重,可根据综合评价值选用较优的路面类型. 相似文献
915.
一种时变滑模平面的设计方法 总被引:5,自引:0,他引:5
在分析滑模平面设计的基础上,指出了按传统的方法设计的滑模平面的缺陷。为了克服此缺陷,根据矩阵分析理论提出了一种新的具有全局鲁棒性的时变滑模平面的设计方法,并给出了三种具体的滑模平面形式。通过理论分析和计算机仿真可以看出,基于该方法设计出滑模平面的变结构控制系统,能保证系统从任意的初始状态开始就处于设定的滑模平面上,对参数摄动和外部干扰具有很强的鲁棒性。用该方法设计出的时变滑模平面是传统的滑模平面的 相似文献
916.
Human β-defensins 总被引:1,自引:0,他引:1
Pazgier M Hoover DM Yang D Lu W Lubkowski J 《Cellular and molecular life sciences : CMLS》2006,63(11):1294-1313
917.
Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism? 总被引:1,自引:0,他引:1
Betaine homocysteine methyltransferase (BHMT), a Zn2+-dependent thiolmethyltransferase, contributes to the regulation of homocysteine levels, increases in which are considered
a risk factor for cardiovascular diseases. Most plasma homocysteine is generated through the liver methionine cycle, in which
BHMT metabolizes approximately 25% of this non-protein amino acid. This process allows recovery of one of the three methylation
equivalents used in phosphatidylcholine synthesis through transmethylation, a major homocysteine-producing pathway. Although
BHMT has been known for over 40 years, the difficulties encountered in its isolation precluded detailed studies until very
recently. Thus, the last 10 years, since the sequence became available, have yielded extensive structural and functional data.
Moreover, recent findings offer clues for potential new functions for BHMT. The purpose of this review is to provide an integrated
view of the knowledge available on BHMT, and to analyze its putative roles in other processes through interactions uncover
to date.
Received 26 May 2006; received after revision 3 July 2006; accepted 24 August 2006 相似文献
918.
Huet J Wyckmans J Wintjens R Boussard P Raussens V Vandenbussche G Ruysschaert JM Azarkan M Looze Y 《Cellular and molecular life sciences : CMLS》2006,63(24):3042-3054
Two chitinases, able to use tetra-N-acetylglucosamine, chitin and chitosan as substrates, were characterized after purification from Carica papaya latex. The complete amino acid sequence of the major form and about 40% of the minor one were determined through proteolytic
digestions and mass spectroscopy analysis. Sequencing demonstrated that both papaya chitinases are members of the family 19
of glycosyl hydrolases (GH19). Based on the known 3-D structures of other members of family GH19, it was expected that papaya
chitinases would adopt all-alpha structures. However, circular dichroism and infrared spectroscopy indicated, for the papaya
chitinases, a content of 15–20% of extended structures besides the expected 40% of alpha helices. Since the fully sequenced
papaya chitinase contains a large number of proline residues the possibility that papaya chitinase contains polyproline II
stretches was examined in the context of their resistance against proteolytic degradation.
Received 11 July 2006; received after revision 13 October 2006; accepted 25 October 2006 相似文献
919.
经济系统发展动力结构优化模型与评价方法 总被引:2,自引:0,他引:2
以产出型生产函数为基础构建了目标函数为人均增长速度最大的经济系统发展动力结构优化模型 ,给出了最优动力结构的特征和条件以及实际动力结构与最优动力结构之间差异程度的评价方法. 相似文献
920.
基于物质结构实在性和非线性演化模型而提出的溃变理论是非线性理论的观念性观点。本文从四个方面概括了非线性溃变理论的物质系统不同于西方第一推动体系的制约观。(1)在整体观中具体完善了事物演化的“稳定,渐变,不稳定,突变,通过不连续溃变并演化为新的稳定,渐变……”的系统整体演化链。(2)以物质结构的非均匀性提出了第二搅动下物质的涡旋结构观,揭示了“天人合一”的物质性。(3)在结构信息控制观中阐述了非均匀 相似文献