高k栅MOSFET栅–源/漏寄生电容的半解析模型

文章针对高k栅MOSFET的栅介质层及其侧壁掩蔽层提出了一个二维定解问题,求出了二维电势和电荷分布.文章根据栅极电荷与栅源及栅漏电压关系,提出了MOSFET的栅极和源极/漏极之间的寄生电容的模型,用半解析法计算了这些寄生电容,得到了寄生电容与几何尺寸之间的关系.文章的计算结果表明改变栅极电介质常数可以得到一个寄生电容的最小值,计算结果与CST仿真结果能够很好地符合.     

一种用于动态光散射测量的虚拟数字相关仪

根据数字相关的基本原理, 利用高速数据采集卡和实验室虚拟仪器工程平台LabVIEW, 设计开发用于动态光散射测量的数字相关仪. 利用该数字相关仪对动态光散射实测数据进行分析处理, 给出散射光强的时间自相关函数曲线, 反演计算了颗粒粒度, 并与已知粒度进行比较, 得到较好的测试结果.      

无人机自主着陆半实物仿真系统设计

无人机自主着陆系统设计是实现大型无人机自主着陆的关键课题。设计了一种基于分米波仪表着陆技术体制的无人机自主着陆半实物仿真系统,用于设计和验证无人机着陆引导系统的稳定性、可靠性以及相关性能指标,替代工程研制的实际试飞,避免承担风险和节省大量人力物力财力。无人机自主着陆半实物仿真系统设计包括分米波仪表着陆系统地面和机载设备模拟器、无线电高度表模拟器和激光测高仪模拟器、无人机数学模型仿真机和飞行控制仿真机以及仿真主控计算机等。实现了对无人机自主着陆全过程的仿真试验,仿真数据可作为研制无人机着陆引导实物系统的重要参考。     

On the mechanism of inhibition of p27 degradation by 15-deoxy-Δ12,14-prostaglandin J 2 in lymphoblasts of Alzheimer’s disease patients

It has been proposed that neuroinflammation, among other factors, may trigger an aberrant neuronal cell cycle re-entry leading to neuronal death. Cell cycle disturbances are also detectable in peripheral cells from Alzheimer’s disease (AD) patients. We previously reported that the anti-inflammatory 15- deoxy-Δ^12,14-prostaglandin J ₂ (15d-PGJ ₂) increased the cellular content of the cyclin-dependent kinase inhibitor p27, in lymphoblasts from AD patients. This work aimed at elucidating the mechanisms of 15d-PGJ ₂-induced p27 accumulation. Phosphorylation, half-life, and the nucleo-cytoplasmic traffic of p27 protein were altered by 15d-PGJ2 by mechanisms dependent on PI3K/Akt activity. 15d-PGJ ₂ prevents the calmodulin-dependent Akt overactivation in AD lymphoblasts by blocking its binding to the 85-kDa regulatory subunit of PI3K. These effects of 15d-PGJ ₂ were not mimicked by 9,10-dihydro-15-deoxy-Δ^12,14- prostaglandin J ₂, suggesting that 15d-PGJ ₂ acts independently of peroxisome proliferator-activated receptor γ activation and that the α,β-unsaturated carbonyl group in the cyclopentenone ring of 15d-PGJ ₂ is a requisite for the observed effects. Received 14 July 2008; received after revision 2 September 2008; accepted 12 September 2008     

Anti-amyloidogenic therapies: strategies for prevention and treatment of Alzheimer’s disease

Deposition of amyloid β-protein (Aβ) in the brain is an early and invariant neuropathological feature of Alzheimer’s disease (AD). The current search for anti-AD drugs is mainly focused on modification of the process of accumulation of Aβ in the brain. Here, we review four anti-amyloidogenic strategies: (i) reduction of Aβ production, which has mainly been approached with secretase inhibition, (ii) promotion of the Aβ degrading catabolic pathway, including an Aβ degrading enzyme, neprilysin, (iii) immunotherapy for Aβ and (iv) inhibition of Aβ aggregation. We have reported that AD patients have a favorable molecular environment for Aβ aggregation and that various compounds, such as polyphenols, interfere with Aβ aggregation and destabilize preformed Aβ fibrils. Received 21 December 2005; received after revision 14 February 2006; accepted 29 March 2006     

Glycogen synthase kinase 3β and Alzheimer’s disease: pathophysiological and therapeutic significance

Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral dysfunction and is the leading cause of dementia in the elderly. Several studies have implicated molecular and cellular signaling cascades involving the serine-threonine kinase, glycogen synthase kinase β(GSK-3β) in the pathogenesis of AD. GSK-3β may play an important role in the formation of neurofibrillary tangles and senile plaques, the two classical pathological hallmarks of AD. In this review, we discuss the interaction between GSK-3β and several key molecules involved in AD, including the presenilins, amyloid precursor protein, tau, and β-amyloid. We identify the signal transduction pathways involved in the pathogenesis of AD, including Wnt, Notch, and the PI3 kinase/Akt pathway. These may be potential therapeutic targets in AD. Received 19 December 2005; received after revision 24 January 2006; accepted 6 February 2006     

过程控制的实验模型研制

实例研究DELTA LC、HITECH触摸终端、DELTA变频器、AI智能仪表等工控技术的应用及其相互之间的通信和系统整合,将工业现场的实际控制对象提炼成一个实物模型,可作为学生课程设计或毕业设计的学习平台．     

柳永词的用典及其诗化倾向

考察《乐章集》,我们发现其各类题材用典的频率都较高,特别是都市题材的词作用典频率更高。柳永作为第一个专职词人,因其在创作时大量运用典故,使词具有了＂诗化＂、＂雅化＂倾向,使＂词＂逐渐被文人认可而登上＂大雅＂之堂。     

普林格尔治疗仪促进产后乳汁分泌的疗效观察

目的：观察普林格式治疗仪促进产后乳汁分泌的疗效。方法各选取100例产后30 d乳汁量少的产妇，一组接受普林格尔治疗仪治疗，称为观察组，一组只接受传统方法治疗，称为对照组，观察两组产妇乳汁量的变化。结果经过普林格尔治疗仪治疗和指导的观察组效果明显优于只接受传统方法治疗的对照组，差异具有显著性（p〈0.05）。结论普林格尔治疗仪有利于促进产妇产后的乳汁分泌，且操作简单、风险小、无副作用，值得推广。     

20世纪20年代以来的东北少数民族村寨研究

对20世纪20年代乡村社区研究兴起以来涉及到东北地区少数民族村寨的学术活动和研究成果进行了简单梳理,认为东北地区少数民族村寨的研究过程可分为三个阶段,分别是20世纪20年代至40年代的起步阶段,50年代至70年代的发展阶段以及80年代至今的繁荣阶段。在论述各阶段研究特点的基础上,提出东北地区少数民族村寨的后续研究需要研究者有效兼顾民族志书写和理论剖析两个方面,从而实现对研究对象更为全面、客观、理性的认识和探究。