制冷循环中的损失分析计算

本文由热力过程损失导出计算制冷循环的总损失ＥＬ的表达式；并证明ＥＬ≥０．用这种分析法计算了使用非共沸工质的劳伦兹循环的总损失ＥＬＺ，并与逆郎肯循环对比．结果表明两者的制冷系数都受到工质吸热过程的平均温度和放热过程平均温度的制约．     

Compensatory caspase activation in MPP+-induced cell death in dopaminergic neurons

Many have hypothesized that cell death in Parkinsons disease is via apoptosis and, specifically, by the mitochondrial-mediated apoptotic pathway. We tested this hypothesis using a mouse dopaminergic cell line of mesencephalic origin, MN9D, challenged with the Parkinsonism-causing neurotoxin MPP⁺ (1-methyl-4-phenylpyridinium ion). Apoptosis was the main mode of cell death when the cells were subjected to MPP⁺ treatment under serum-free conditions for 24 h. Caspase-3 and caspase-9, however, were not activated, thus indicating the existence of alternate or compensatory cell death pathway(s) in dopaminergic neuronal cells. Using caspase inhibitors, we demonstrated that these pathways involve caspase-2, –8, –6 and –7. A time-course study indicated that activation of caspase-2 and –8 occurred upstream of caspase-6 and caspase-7. Upon MPP⁺ challenge, the apoptosis-inducing factor was translocated from the mitochondria into the MN9D cytosol and nucleus. These results suggest the existence of alternative apoptotic pathways in dopaminergic neurons.Received 20 September 2004; received after revision 5 November 2004; accepted 22 November 2004     

Functional and physical communication between oncoproteins and tumor suppressors

The discovery of oncogenes (c-onc’s) and tumor suppressors (TS’s) has led to the concept that cancer arises from defects in each of these classes of genes or their products. More recently, it has been appreciated that c-onc and TS proteins often affect one another’s functions. Within this context, I review the two classical TS’s, p53 and the retinoblastoma protein, and the consequences of their inactivation. The various forms of genomic instability (GI) that underly the high mutation rates of transformed cells are then discussed. Particular emphasis is placed upon the concept that GI is not only an integral part of the transformed state but is a prerequisite. Increased oxidative DNA damage, and/or an inabiliy to repair it, can lead to GI. The review then discusses recent observations showing that loss of the TS protein peroxiredoxin 1 (prdx1) and increased expression of the c-onc protein c-Myc, each leads to increased oxidative DNA damage. The critical nature of the c-onc-TS interaction is underscored by that occurring between prdx1 and c-Myc, with the former protein regulating the production of DNA-damaging reactive oxygen species by the latter. The intimate association between these proteins and others serves as a paradigm for the exquisite balancing act that c-onc’s and TS’s must maintain in order to properly control normal DNA replication and cellular proliferation while simultaneously minimizing the acquisition of potentially neoplastic mutations. Received 10 May 2005; received after revision 3 July 2005; accepted 19 July 2005     

多元累积和控制图

讨论了两种多元累积和图.第1种是利用 Hotelling 统计量进行累积和,形成多元累积和控制图,并讨论了它的平均游程长度(ARL);第2种是在已知偏移状态下,用序贯概率比检验法将多元累积和问题转化为一元累积和问题.这两种方法的前提都是随机变量服从正态分布.     

新型纱线定长(测长)器的研制

络筒机在络纱时容易造成纱线长度长短不一，这将导致后续整经工序中纱线的巨大浪费。笔者研制出一种新型纱线测长器，在纱线卷绕的过程中对其进行精确测量，达到减小误差、节约成本的目的。     

有偿债基金机制的公司债定价模型

有偿债基金的公司债是发行公司专门提取偿债基金以保证本息偿还的公司债券,它具有提前偿还的性质.由于计提偿债基金会引起公司资产的跳跃,给出了公司在计提偿债基金前没有违约的概率以及在此条件下公司资产的条件分布,并利用首次通过模型得到债券定价公式,通过数值计算作图分析了债券价格随参数变化的金融意义.     

中立型抽象微分方程Sp-权伪概周期弱解的存在性

 利用中立型微分方程S^p-权伪概周期函数的一个新分解定理和Krasnoselskii’s不动点定理,得到了中立型抽象微分方程的S^p-权伪概周期弱解存在性条件.     

Banach空间中相对非扩张映射的强收敛定理

用修正后的Halpern's迭代方法在Banach空间建立了一个迭代序列,证明了这一迭代序列强收敛到2个相对非扩张映射的公共不动点.     

论张志和《渔歌子》的江南话语

江南,是张志和《渔歌子》建构的核心意象。通过对历史语境的还原和文本内涵的解读,不难发现这一意象,不仅是张志葙的叙述场域,也是一种叙述话语,即江南话语,它传达出了隐逸诗人张志和在“家国同构”的认同传统下内心激烈的斗争和挣扎。