Characterization of impurities in the bulk drug lisinopril by liquid chromatography/ion trap spectrometry

Two trace impurities in the bulk drug lisinopril were detected by means of high-performance liquid chromatography coupled with mass spectrometry （HPLC/MS） with a simple and sensitive method suitable for HPLC/MSn analysis. The fragmentation behavior of lisinopfil and the impurities was investigated, and two unknown impurities were elucidated as 2-（6-amino- l-（l-carboxyethylamino）- l-oxohexan-2-ylamino）-4-phenylbutanoic acid and 6-amino-2-（l-carboxy-3-phenylpropylamino）-hexanoic acid on the basis of the multi-stage mass spectrometry and exact mass evidence, The proposed structures of the two unknown impurities were further confirmed by nuclear magnetic resonance （NMR） experiments after preparative isolation.     

地铁隧道水平冻结法施工冻结壁温度场影响参数分析

以地铁隧道水平冻结法施工中最常见的粉质粘土为例,应用大型数值分析软件ANSYS系统研究冻结管直径、冻结管间距、盐水温度、土层含水量4大因素对冻结法施工中温度场的影响,提出各因素对冻结壁厚度和冻结时间的灵敏度公式;在各影响因素下通过灵敏度对比分析,得出各因素对冻结壁厚度灵敏度影响规律,该影响规律由大到小依次为:盐水温度、冻结管间距、冻结管直径、土层含水量.     

单层球形网壳的弹性屈曲分析及其试验研究

本文对单层球形网壳的弹性屈曲进行了理论分析及结构模型试验。结合结构大位移问题的特点,编制了结构稳定分析的有限元程序,用该程序对一单层球形网壳进行了分析计算,对比试验结果表明所用理论是可靠的,所编程序是有效的。本文对所用理论作了评述,并提出了今后研究的方向。     

气相色谱法测定野生植物种子中的脂肪酸

为探索新的油料资源，对野生植物种子的脂肪酸组成进行了研究。以正己烷／乙醚（Ｖ／Ｖ＝４／３）作提取剂，０．４ｍｏｌ／Ｌ的氢氧化钾－甲醇溶液作甲酯化试剂，采用室温下快速酯交换法制备脂肪酸甲酯，气相色谱法测定了６种野生植物种子中的脂肪酸组成及含量。样品所含主要脂肪酸为棕榈酸、油酸、亚油酸。其中５种野生植物种子的亚油酸含量为６０．４５％～７９．９６％。与几种常见植物油的脂肪酸组成进行了对比，结果表明，被测样品的脂肪酸组成与常见植物油是类似的，但其亚油酸含量普遍高于植物油。同时还分析了几种水果子的脂肪酸含量。     

稳定近地面层Monin-Obukhov长度的解析解

将空气动力学方法迭代求解Monin-Obukhov（M-O）长度的过程,转化为非线性理论中求解映射不动点的问题,获得稳定近地面层M-O长度的解析解。求解过程中采用了Dyer归纳的通量廓线关系的无量纲函数形式,并给出解析解的适用范围是Richardson数（Ri）小于0.2。通过对中国夏、冬两季各2种典型稳定层结条件算例的计算,验证了解析解与迭代解的一致性。根据非线性科学中关于映射不动点稳定性的理论,讨论了迭代算法的收敛性,表明迭代算法在理论上可以收敛到解析解,但在 Ri 接近0.2时误差较大。     

Fine three-dimensional P-wave velocity structure beneath the capital region and deep environment for the nucleation of strong earthquakes

A detailed 3-D P-wave velocity model of the crust and uppermost mantle under the capitol region is determined with a spatial resolution of 25 km in the horizontal direction and 4-17 km in depth. We used 48750 precise P-wave arrival time data from 2973 events of local crustal earthquakes, controlled seismic explosions and quarry blasts. These events were recorded by 123 seismic stations. The data are analyzed by using a 3-D seismic tomography method. Our tomographic model provides new information on the geological structure and complex seismotectonics of this region. Different patterns of velocity structures show up in the North China Basin, the Taihangshan and the Yanshan Mountainous areas. The velocity images of the upper crust reflect well the surface geological, topographic and lithological features. In the North China Basin, the depression and uplift areas are imaged as slow and fast velocity belts, respectively, which are oriented in NE-SW direction. The trend of velocity anomalies is the same as that of major structure and tectonics. Paleozoic strata and Pre-Cambrian basement rocks outcrop widely in the Taihangshan and Yanshan uplift areas, which exhibit strong and broad high-velocity anomalies in our tomographic images, while the Quaternary intermountain basins show up as small low-velocity anomalies. Most of large earthquakes, such as the 1976 Tangshan earthquake (M 7.8) and the 1679 Sanhe earthquake (M 8.0), generally occurred in high-velocity areas in the upper to middle crust. However, in the lower crust to the uppermost mantle under the source zones of the large earthquakes, low-velocity and high-conductivity anomalies exist, which are considered to be associated with fluids, just like the 1995 Kobe earthquake (M 7.2) and the 2001 Indian Bhuj earthquake (M 7.8). The fluids in the lower crust may cause the weakening of the seismogenic layer in the upper and middle crust and thus contribute to the initiation of the large crustal earthquakes.     

基于多目标遗传算法的吸声覆盖层参数优化设计

针对圆柱空腔吸声覆盖层低、高频吸声的机制不同,提出了一种基于多目标遗传算法的吸声覆盖层参数优化设计方法.利用有限元软件ANSYS建立了平面波垂直入射吸声覆盖层的分析模型,并采用多目标遗传算法NSGA-II得到了多目标吸声问题的Pareto最优解集.结果表明：多目标优化设计全面考虑了圆柱空腔吸声覆盖层的低、高频吸声之间的耦合,可按需选择其满意的优化结果;比起仅优化吸声覆盖层的材料属性,考虑材料属性和结构参数的综合优化能够获得更佳的宽频吸声性能.     

高聚物反相填料在分离纯化莱菔硫烷中的应用

采用高聚物反相填料装填的半制备柱(PST, 30μm, 300mm×10mm ID)对莱菔硫烷进行分离纯化,优化了色谱分离参数,确定最佳流动相为30%乙腈-水溶液,流速为2mL/min等度洗脱,检测波长254nm,进样量不超过20mg时,收率在61%以上,纯度可达90%。采用中心切割的方式收集,获得的产品纯度可达90%以上。     

L-fuzzy闭包空间的层紧性

文章引入了 L F闭包空间及其层紧性的概念 ,并且用滤子和网给出了层紧性的等价刻画 ,证明了层紧性在C连续的 L-值 Zadeh型函数下是不变的 .最后给出了链所具有的特征。     

绕流三角形钝体的通道流场的数值预测

本文从流体流动和传热的角度,对二维平行平板通道中空气绕流三角形钝体的流场进行了数值预测和相应的实验验证。湍流的时均值方程组用k-ε模型封闭,并经流函数-旋涡度变换后用有限差分法进行数值求解,在对流场壁面边界的处理上采取了更为简便的近似办法。