线性模型中误差分布的基于L1估计的相合核估计

线性模型ｙｉ＝ｘｉ＇β＋ｅｉ，ｉ＝１，…，ｎ，的误差序列｛ｅｉ｝ｉ＾ｎ＝１有未知密度ｆ（ｘ）。本文在一定条件下证明了ｆ（ｘ）的核估计ｆｎ（ｘ）＝１／ｎａｎ∑＾ｎｉ＝１ｋ（ｅｎｉ－ｘ／ａｎ）的弱相合性，逐点强相合性，一致强相合性，其中ｅｎｉ为Ｌ１估计的残差。     

核酸序列的模糊聚类与分子进化

将核酸序列(编码区)分成几类,求出每类的平均信息参数(D_L),用模糊聚类的方法研究它们的相似性和同源性,求出各级相似分岔值并导出动态聚类图.证明了短程相似分岔与序列进化有明显的相性,即L=2-5的一级相似分岔值与物种出现地质年代的对数保持较好的线性关系.     

由氨基酸序列预测蛋白质二级结构的进一步研究

本文在工作[1][2]的基础上进一步研究了蛋白质二级结构的经验预测,着重讨论了如何制定预测规则的问题,并将预测工作计算机化.在蛋白质资料库中随机选取了21个蛋白质(3296残基)进行预测,正确率对α螺旋和β折迭分别为84.4%和81.9%.     

陕北长6油层组短期基准面旋回与储层非均质性的关系

鄂尔多斯盆地上三叠统延长组长６油层组为一套砂、泥薄互层的组合类型,储层非均质性很强,尤以层间的非均质性最为严重,明显受基准面升、降,和可容纳空间及沉积物供给量的变化影响。通过高分辨率层序地层的短期基准面升、降旋回过程与储集物性关系的分析,建立了６种不同沉积微相的非均质性模式,探讨了向上变深、向上变浅的非对称型和向上变深后复变浅的对称型短期基准面旋回层序对储层非均质性特征的控制作用     

泛Barker序列设计

对n相Barker序列进行了分析,将n相Barker序列划分为若干等价类。等价类元素可通过某种变换相互转化,因此,将n相Barker序列设计简化为等价类的设计。用计算机搜索的方法,得出具有某种长度的所有n相Barker序列等价类。采用{-1,0, 1}作为序列的元素集合,也是取得Barker序列的一种手段。通过与2相Barker序列比较,采用类似2相Barker序列结构,得到的奇数长度的三值Barker序列。虽然该序列具有较长的序列长度,但序列的相关增益较小。通过计算机搜索可以得到任意长度、具有最大相关增益的三值Barker序列。     

计算一类递归方程的增广Petri网模型

递归方程的计算一直是一个较为复杂的问题,为更好的解决这一问题,建立各种模型是十分必要的.斐波那契数列是一个著名的递归方程,在这个方程的基础上,针对同类的递归方程建立了增广Petri网模型,并对模型的运行进行了分析.     

序列｛V（n）＝V（n－1）＋V（n－2）＋1｝的若干结构性质

本文主要应用文献［４］的方法，给出了序列｜Ｖ（ｎ）｜的若干新奇的恒等式及一些数论性质。     

Analysis of components of conserved “backbone sequences”among genomes of Shigella spp. strains

Difference in the genomic compositions of prokaryotes is the basis of the diversity in their biological characters. However, besides their flora-or strain-specific genes,those floras with closer relationship in the evolution also have conserved “backbone sequences”, which reveal the marks of their origin and evolution, and these “backbone sequences”are just the basis of their elementary living abilities and common biological properties. Shigella is very closely related to E. coli in the origin and evolution, and may turn out to belong to the same genus. In this study, a microarray containing E. coli K-12 whole genome and Sf301 specific ORFs is used to investigate the genomic components of four Shigella strains. The results indicate that 16%-22% K-12 ORFs sequences are not detected in the genome of Shigella strains while the genome of Shigella contains at least 2800 conserved ORFs, which compose the common “backbone sequences”.Advanced analysis indicated that the “backbone sequences”are the essential components in maintaining the normal physiological activities of intestinal bacteria. Furthermore,only 20% Sf301-specific ORFs exist in other strains simultaneously, which demonstrate the great genome heterogeneity and the genetic diversity among the strains.     

基于PVS的UML类图和序列图的一致性检验

针对UML类图和序列图的一致性问题,在充分考虑了类继承关系、关联关系、类方法的可见性以及类方法的前、后置条件等因素对一致性影响的基础上,给出了判定类图和序列图一致性的必要条件和PVS元理论,提出了一种基于定理证明器PVS的一致性检验方法.在检验UML模型一致性时,把一致性检验问题转化为逻辑定理证明问题.实践表明,该方法对于提高UML模型的可信度,减少系统实现阶段的错误起到了一定作用.     

Snake venom thrombin-like enzymes: from reptilase to now

The snake venom thrombin-like enzymes (SVTLEs) comprise a number of serine proteases functionally and structurally related to thrombin. Until recently, only nine complete sequences of this subgroup of the serine protease family were known. Over the past 5 years, the primary structure of several SVTLEs has been characterized, and now this family includes several members. Of particular interest is their possible use in pathologies such as thrombosis. The aim of the present review is to summarize the state of the art concerning the evolutionary, structural and biological features of the SVTLEs.Received 16 August 2003; received after revision 26 September 2003; accepted 1 October 2003