金雕肾脏及肝细胞的超微结构观察

本文对金雕肾脏和肝细胞的超微结构作了初步观察,结果表明:金雕肾脏具有极周细胞,其内含丰富的膜包颗粒.肾小体之滤过屏障结构与家鸡相似.肝细胞具发达的粗面内质网.     

The neurotrophic factors in non-neuronal tissues

Although neurotrophic factors are defined as molecules that maintain neuronal cells, they possess a range of functions outside the nervous system. For example, glial cell line-derived neurotrophic factor is essential for ureteric branching in kidney morphogenesis and for regulating the fate of stem cells during spermatogenesis. Leukemia inhibitory factor, a member of the interleukin-6 (IL-6) ciliary neurotrophic factor family, inhibits differentiation of embryonic stem cells, induces tubulogenesis in the embryonic kidney, and regulates sperm differentiation. Other IL-6 family members are important in cardiac differentiation and they have pleiotropic functions in the hematopoietic and immune systems. Although neurotrophin receptors have been found on a number of non-neuronal tissues, they represent mostly truncated receptor isoforms that are incapable of signal transduction and may have scavenger or dominant negative functions. However, several examples can be presented of essential non-neuronal functions played by neurotrophins in e.g., cardiac, hair follicle, and vascular differentiation, and the maintenance of immune cells.     

姜黄素对鼻咽癌细胞株CNE-2Z—H5裸鼠移植瘤增殖的影响

目的：研究姜黄素对人低分化鼻咽癌细胞系亚克隆株CNE-2Z—HS裸鼠移植瘤生长和增殖的影响。方法：复制人低分化鼻咽癌细胞系亚克隆株CNE-2Z-H5裸鼠移植瘤模型，观察姜黄素对移植瘤生长的影响。结果裸鼠体内实验显示姜黄素可以抑制移植瘤的生长。不同浓度姜黄素组移植瘤瘤重与溶剂对照组比较有降低趋势，高剂量组降低更明显，差异有极显著性（P〈O．001），抑瘤率达59．75％。结论姜黄素可以抑制CNE-2Z—H5细胞裸鼠移植瘤的生长，其可能在鼻咽癌的治疗中具有一定的价值，值得进一步深入研究。     

卡托普利和肾切除对肾性高血压大鼠左室心肌MHC基因转录变化的影响

用二肾一夹（２ＫＩＣ）肾性高血压大鼠模型，探讨心肌肥厚发生和逆转以及肌球蛋白重链（ｍｙｏｓｉｎｈｅａｖｙｃｈａｉｎ，ＭＨＣ）基因表达的改变。结果表明：１）２ＫＩＣ肾性高血压大鼠术后第２～１２周，动脉血压持续升高、左室重量／体重（ＬＶＷ／ＢＷ）明显升高、左心室α－ＭＨＣ基因表达明显减弱、β－ＭＨＣ基因表达明显增强；２）在术后第４周给予血管紧张素转换酶抑制剂卡托普利和术后第８周切除肾动脉狭窄侧肾脏可使２ＫＩＣ肾性高血压大鼠动脉血压下降、左心室肥厚发生逆转、抑制左心室α－ＭＨＣ基因表达减弱和β－ＮＨＣ基因表达增强。这些结果提示在２Ｋ１Ｃ肾性高血压中，动脉血压升高是左心室肥厚、左心室肌球蛋白ＭＨＣ基因表型转换的重要因素；肾素———血管紧张素系统可能参与２ＫＩＣ肾性高血压过程中的心肌肥厚和ＭＨＣ基因表型的转移。     

返流性肾病尿微量蛋白变化与肾损害的关系

目的：了解返流性肾病尿微量蛋白变化与肾损害的关系。方法：用放射免疫法对确诊为返流性肾病病儿尿β２微球蛋白（β２－Ｍ）、白蛋白（Ａｌｂ）及免疫球蛋白Ｇ（ＩｇＧ）、Ｔａｍｍ－Ｈｏｒｓｆａｌｌ蛋白（ＴＨＰ）等４项蛋白进行检测。结果：尿β２－Ｍ、Ａｌｂ、ＩｇＧ在返流性肾病的患儿均较正常组增高。重度膀胱输尿管返流的返流性肾病病儿尿ＴＨＰ明显降低，而轻度者尿ＴＨＰ未见降低。结论：返流性肾病病儿除肾小管损害外，     

用药的误区及其理论分析

使用药物是我们日常生活的一个重要部分。但是，人们对药物的使用普遍存在着误区，这些误区导致临床上产生许多药源性的疾病和不可逆的脏器损害。此文章通过对这些误区的分析，给人们正确、合理使用药物提供科学的理论依据。     

Incorporation of32P into renal phospholipids of mice during postnatal growth

Summary During the first 40 days of life the rate of incorporation of³²P into total phospholipids and into phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, diphosphatidylglycerol, phosphatidic acid and phosphatidylinositol of mouse kidney was by some 25–35% higher than in older animals. Results suggest a different involvement of cellular membranes during of normal and compensatory renal growth.     

饮用水的诱变性与肝癌的风险

应用蚕豆根尖微核技术研究了肝癌高发区的扶绥县饮用水的诱变性与肝癌发病的关系。结果表明，检测３２份不同饮水类型的饮用水（饮用塘水、塘边井水、井水、河水和自来水）中有１２份饮用塘水和２份塘边井水能明显诱导蚕豆根尖核率增高（Ｐ〈０．０１），而井水、河水和自来水所诱发的蚕豆根尖微核率与对照组则无显著差异（Ｐ〉０．０５）。提示该县饮用塘水中存在染色体畸变的物质，此类物质在各种饮水类型的水样中所诱发的蚕豆根尖     

中西医结合治疗原发性肾病综合症的临床研究

目的:观察中西医结合治疗原发性肾病综合症的临床疗效,并初步探讨其机理.方法:选择68例中医辨证为脾肾阳虚兼挟血瘀湿浊的PNS患者,随机分对照组33例,用标准激素治疗.治疗组35例,在标准激素治疗基础上加服中药汤剂.结果:治疗组能明显改善症状和体征,减少尿蛋白,降低血粘度及血脂水平(P均＜0.01).治疗组总有效率达91.42%,明显优于对照组78.78%(P＜0.01).