The cold case: Are rhinoviruses perfectly adapted pathogens?

Rhinoviruses, which cause common cold, belong to the Picornaviridae family, small non-enveloped viruses (diameter 15-30 nm) containing a single-stranded RNA genome (about 7 kb). Over 100 different rhinoviral serotypes have been identified thus far, establishing rhinoviruses as the most diverse group of Picornaviridae. Based on receptor binding properties, rhinoviruses are divided into two classes: the major group binding to intracellular adhesion molecule-1 and the minor group binding to the very low density lipoprotein receptors. Interactions between virus and the receptor molecules cause a conformational change in the capsid, which is a prerequisite for viral uptake. Rhinoviruses trigger a chemokine response upon infection that may lead to exacerbation of the symptoms of common cold, i.e. asthma and inflammation. The following review aims to summarize the knowledge about rhinoviral infections and discusses therapeutical approaches against this almost perfectly adapted pathogen.     

软件化雷达信号处理系统总线协议

提出一种基于DSP平台的软件化雷达信号处理系统的总线协议 ,协议包含 4条传输总线和 1条指令总线 ,具有优良的可扩展性、可重构性和通用性。按照此协议 ,以能完成 16个合成阵元通道的相控阵雷达信号处理为目标 ,设计了硬件 ,实现了系统。     

调频步进雷达回波实时数字生成的一种新方法

突破宽带信号数字生成方法的框架 ,提出了基于波形存储和实时计算相结合的调频步进雷达回波高速实时数字生成新方法。基于某调频步进雷达系统的研究 ,提出的解决方案摆脱了传统的波形存储直读法和直接数字合成法的局限性 ,即不适应于变换参数的情况 (比如运动目标 ) ,成功地实现了运动多散射点目标回波的实时产生 ,证明方案可行。还对算法的数值稳定性进行了分析。     

双C50多模同步采集高速目标识别系统

研究了红外多模采集转换的系统模型 ,分析了功能状态。研究了基于并行DSP、数据并行通信芯片和可编程逻辑器件构架的可行性系统实现 ,论证了系统的实时并行处理能力。研究了数字锁相实施玫瑰线扫描同步采集方位转换和红外多帧配准图像模糊分割识别系统实现。实验表明 ,该系统具有 2 5 6× 2 5 6像素场景 ,2 5 6级灰度级实时监测和复杂背景下实时识别目标的能力。     

Huntington’s disease: from huntingtin function and dysfunction to therapeutic strategies

Huntington’s disease (HD) is a neurodegenerative disorder that usually starts in middle age and is characterized by involuntary movements (chorea), personality changes and dementia, leading to death within 10–20 years. The defective gene in HD contains a trinucleotide CAG repeat expansion within its coding region that expresses a polyglutamine repeat in the protein huntingtin. Together with the characteristic formation of aggregates in HD, aberrant protein interactions and several post-translational modifications affect huntingtin during disease progression and lead to the dysfunction and death of selective neurons in the brains of patients. The exact molecular mechanisms by which mutant huntingtin induces cell death are not completely understood but may involve the gain of new toxic functions and the loss of the beneficial properties of huntingtin. This review focuses on the cellular functions in which huntingtin is involved and how a better understanding of pathogenic pathways can lead to new therapeutic approaches. Received 24 May 2006; received after revision 5 July 2006; accepted 23 August 2006     

高频雷达中LFMCW信号的分析

高频雷达在现代战争和民用事业上发挥着越来越重要的作用 ,线性调频连续波 ( L FMCW)信号是高频雷达常采用的信号形式。就 L FMCW信号在高频雷达中的应用作了具体分析 ,并导出了其差频相位的具体表达式 ,它表现出了要检测的各量的物理意义 ,对检测的方法提供了理论依据。在此基础上 ,利用二维 FFT处理技术对目标回波信号的信息提取进行了仿真 ,并对仿真结果进行了分析     

基于循环累积量的星形QAM载波盲估计

针对通信对抗和正交幅度调制(QAM)信号解调的实际应用,提出一种利用特定高阶循环累积量估计星形QAM载波的方法。由于高阶循环累积量能有效抑制平稳噪声和非平稳高斯噪声,通过理论分析可证明在上述噪声背景下,星形8、16 QAM信号的特定四阶循环累积量仅在载波位置处存在,因此可以通过检测此循环频率实现载波的估计。该算法可推广到更高阶星形QAM信号。仿真实验验证了该算法的有效性。     

采用以太通信的数字信号处理系统

介绍Analog Device公司的数字信号处理器（DSP）通过网络接口设备——串行网络接口控制器（SNIC）与PC进行通信的硬件和软件设计,并给出了以太通信用于实时数据传输的实例．