Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

Summary Using flurbiprofen, a chiral anti-inflammatory and analgesic 2-arylpropionic acid derivative, the enantiomers of which are not converted to each other (less than 5%) in rats or man, we obtained evidence that prostaglandin synthesis inhibition is primarily mediating the anti-inflammatory activity but prostaglandin synthesis independent mechanisms contribute to the analgesic effects. Thus, the S-form inhibited prostaglandin synthesis, inflammation and nociception in rats. The R-form had much less effect on prostaglandin synthesis and did not affect inflammation. It did, however, block nociception in rats almost as potently as the S-form. S-flurbiprofen, in contrast to the R-form, was clearly ulcerogenic in the gastrointestinal mucosa. These results indicate additional molecular mechanisms of analgesia and suggest the use of R-arylpropionic acids as analgesics.     

关于创新教育内容与途径的探讨

教育创新是时代的呼唤，是我们国家创新体系的重要组成部分。在知识经济时代，我们应该从多方面积极探索丰富创新教育的时代内涵及创新教育的有效途径与方法。     

概率论与数理统计课程教学改革初探

结合教学实践,从教材和教学模式两方面探讨了概率论与数理统计的教学改革。     

Disruption of mitochondrial function as the basis of the trypanocidal effect of trifluoperazine onTrypanosoma cruzi

Summary The tricyclic anti-calmodulin drug trifluoperazine (TFP) inhibited growth and motility of epimastigotes ofTrypanosoma cruzi, at concentrations lower than 100 M, and motility and infectivity of the bloodstream trypomastigote form at 200 M. Electron microscopy of TFP-treated epimastigotes showed that the major effect was at the mitochondrial level, with gross swelling and disorganization. The oligomycin-sensitive, mitochondrial ATPase was completely inhibited by 20 M TFP, and the same drug concentration caused a 60% decrease in intracellular ATP content. The results suggest that the trypanocidal effect of TFP may be related more to mitochondrial damage than to the well-known anticalmodulin effect of the drug.     

Retention of topical liposomal formulations on the cornea

Summary The ability of liposomes composed of different kinds of phospholipid materials to adhere to the surface of the cornea was studied in the rabbit. The liposomes were labelled with tracer amounts of an I¹²⁵-labelled phosphatidylethanolamine derivative and were instilled in 10 l drops onto the cornea. The retention of radioactivity was monitored. The results show that liposomes containing positively charged phospholipids are better retained than an albumin control. Thus, it may be possible to develop a drug delivery, liposome system which would permit long-term sustained release of ophthalmic drugs onto the cornea.     

高等学校培养高层次创新人才的积极因素

探讨了高等学校培养创新人才的若干积极因素。在高校推行师生的同化关系，师生之间相互融合，教学相长；对师生的权力进行重新分配，形成互动的互补的课堂氛围；使学生提出质疑成为一种习惯，才能真正地培养出高层次创新性人才。     

浅议对学生创新意识和思维能力的培养

文章试图从解释化学教学中学生创新意识和思维能力的重要性出发，探讨教学过程中如何加强学生创新意识和思维能力的培养，从而鼓励学生创新思维，调动学生学习积极性和主动性。     

创新型教师的特征及其角色定位

创新型教师应该具有开放性、主体性、创新性、协同性等健全的创新型人格特征和较强的教育创新能力，并应从本位化、个性化和民主化三个方面进行角色定位，这就要求教师从观念上和技术上都要完成相应的角色转换。     

铂类抗癌药物研究进展

综述了铂类抗癌药物的抗癌机理、研究进展,并指出了铂类抗癌药物存在的问题以及未来的研究趋势.     

如何指导大学生进行数学建模竞赛

数学的广泛应用被视为科技进步的重要标志之一 ,通过构建和运用数学模型来解决实际问题 ,反映了数学应用发展的新阶段 .开展数学建模竞赛是培养高素质人才的一条重要途径 .提高大学生的数学建模能力和竞赛成绩 ,教师应重视从以下几个方面开展指导工作 :一、巩固学生的数学基础 ,培养应用意识 ,并使二者有机结合和相互促进 ;二、开发学生的想象力 ,通过探索讨论、小组活动与大型作业等途径提高学生的创新能力 ;三、激发学生的集体荣誉感 ,通过合作小组内的合理分工、密切协作和联合攻关 ,增强学生的合作意识 ;四、使学生掌握数学建模竞赛论文的结构 ,写作的具体要求和特点