A cooperative Co-evolutional immune algorithm

A co-evolutional immune algorithm for the optimization of a function with real parameters is de-scribed.It uses a cooperative co-evolution of two populations,one is a population of antibodies and theother is a population of successful mutation vectors.These two population evolve together to improve thediversity of the antibodies.The algorithm described is then tested on a suite of optimization problems.The results show that on most of test functions,this algorithm can converge to the global optimum atqu...     

免疫激活:关于toll样受体与nod样受体的探索

toll样受体和nod受体在天然免疫应答中是重要的家族。激发配体促进受体相互作用的精确检测从而导致多重信号的形成和多级信号转导的触发。这个过程能导致促炎因子的上调、细胞凋亡和调控其他免疫防御。最近,在这些受体家族中识别激活配体和配体的分子基础的检测上有重大进展。理解这些过程,对于新的疫苗佐剂的开发、感染性疾病的治疗、炎症反应和潜在的疾病甚至癌症,都提供了必要的信息。     

Antimicrobial activity in the skin of the channel catfish Ictalurus punctatus: characterization of broad-spectrum histone-like antimicrobial proteins

Three antibacterial proteins were isolated from acid extracts of channel catfish (Ictalurus punctatus) skin by cation exchange chromatography and reverse-phase high-pressure liquid chromatography. The molecular masses of the proteins were 15.5, 15.5 and 30 kD as determined by SDS-polyacrylamide gel electrophoresis. Mass spectrometry, amino acid composition and amino acid sequence data suggest that the most abundant protein is closely related to histone H2B. The H2B-like protein was inhibitory to Aeromonas hydrophila and Saprolegnia spp., which are important bacterial and fungal pathogens of fish. These findings suggest that histones may be important defensive molecules in fish. Received 22 December 1997; received after revision 5 March 1998; accepted 5 March 1998     

小鼠皮肤移植特异耐受性的获得

通过２个不同品系小鼠间进行皮肤移植，研究免疫系统产生特异耐受的机制。要获得对异体抗原的特异性耐受的机制。要获得对异体抗原的特异性耐受，必要包括对中淋巴器官中免疫效应细胞的特样伤，并同时诱导中枢免疫器官将其作为“自我”物质进行识别，导致系列克隆流产。     

Some latest achievements in immunology research

Immunology has become as an attractive discipline of biomedical science in the 21st century,integrated with the rapid development of molecular biology,cell biology,structural biology,genetics and other branches in life sciences.A special issue of Sci China Life Sci was published in February 2010 to highlight recent progresses in immunology.Six review articles focusing on various specific topics were contributed by leading scientists who work in respective fields of immunology.Some progresses of immunology research in China are also described.     

PLC控制系统传导干扰源与抗干扰分析

分析了PLC控制系统在实际应用中可能受到的传导干扰类型，提出了针对性的抗干扰措施。     

Windows系统下的计算机病毒免疫技术

随着计算机病毒危害的日益严重,计算机病毒免疫技术也越来越凸显其重要地位。本文首先简单介绍了生物免疫系统对于计算机病毒免疫的启发,接着详细讨论了目前流行的对计算机病毒免疫的定义,分析了计算机病毒免疫的方法策略以及局限性,最后对流行的冰河木马如何免疫进行了特例分析。     

猪O型口蹄疫母源抗体消长规律的测定和免疫效果观察试验

本试验测定了6窝母猪免疫后产小猪0、1、7、14、21、28、35、42日龄O型口蹄疫母源抗体消长情况和首免、二免免疫抗体测定。结果表明:未吃初乳的0日龄仔猪均无母源抗体,1日龄仔猪母源抗体滴度达到高峰,以后逐渐降低;口蹄疫母源抗体对1～14日龄的仔猪有保护,部分仔猪在21日龄还有保护。28～35日龄首免后21日其免疫抗体合格率低于70%,28日后达到峰值86.7%,一个月后再免一次,则有效免疫抗体水平可维持较长时间,以后逐渐降低,至5个月后已不能保护,种猪此时须再次免疫接种猪口蹄疫疫苗。     

仔猪猪瘟母源抗体及免疫抗体监测实验研究

由于猪瘟流行性差异,研究制订符合本地实际的猪瘟免疫程序是有效防控猪瘟的关键措施之一,而确定仔猪最佳首免日龄和免疫剂量是研究猪瘟免疫程序的两个重要内容。本文提出应用PPA(酶标葡萄球菌蛋白A)-ELISA法对达县某猪场进行了仔猪猪瘟母源抗体及免疫抗体监测实验研究,实验结果表明25日龄为最佳免疫日龄,1倍剂量为最佳免疫剂量。     

半导体（砷化镓）激光照射对犬创伤愈合及细胞免疫机能的影响

以犬为试验动物研究了半导体 (砷化镓 )激光照射创面对皮肤缺损创愈合以及血液中酯酶染色阳性淋巴细胞数的影响。结果表明 ,用波长 890nm ,平均功率 2mW ,峰值功率 5W的半导体激光照射创面可使边长 2cm的正方形犬皮肤全层缺损创平均提前 3.5 1d愈合 ,并使血液中酯酶染色阳性淋巴细胞数明显提高