基于智能虚拟环境的地铁站台仿真系统

实现了一个用于列车驾驶培训的地铁站台仿真系统.系统由一个可被感知的站台虚拟环境和虚拟乘客系统组成.站台环境由静态场景、动态场景两部分组成,可在用户控制下发生变化.虚拟乘客通过感知站台环境的变化做出行为判断与动作.乘客仿真模型采用分层结构,分别实现环境感知、决策、行为选择、动作实现与实时绘制.目前,该系统已用于地铁列车仿真器,成为培训司机站台操作的工具.     

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

Sirtuins comprise a unique class of nicotinamide adenine dinucleotide (NAD⁺)-dependent deacetylases that target multiple protein substrates to execute diverse biological functions. These enzymes are key regulators of clinically important cellular and organismal processes, including metabolism, cell division and aging. The desire to understand the important determinants of human health and lifespan has resulted in a firestorm of work on the seven mammalian sirtuins in less than a decade. The implication of sirtuins in medically important areas such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease has further catapulted them to a prominent status as potential targets for nutritional and therapeutic development. Here, we present a review of published results on sirtuin biology and its relevance to human disease. Received 25 June 2008; received after revision 20 August 2008; accepted 29 August 2008     

The neurotrophic receptor TrkB: a drug target in anti-cancer therapy?

Increasing evidence implies altered signaling through the neurotrophic receptor tyrosine kinase TrkB in promoting tumor formation and metastasis. TrkB, sometimes in conjunction with its primary ligand BDNF, is often overexpressed in a variety of human cancers, ranging from neuroblastomas to pancreatic ductal adenocarcinomas, in which it may allow tumor expansion and contribute to resistance to anti-tumor agents. In vitro, TrkB acts as a potent suppressor of anoikis (detachment-induced apoptosis), which is associated with the acquisition of an aggressive tumorigenic and metastatic phenotype in vivo. In view of its predicted contribution to tumorigenicity and metastasis in humans, TrkB corresponds to a potential drug target, and preclinical models have already been established. The encouraging results of pharmacological Trk inhibitors in tumor xenograft models suggest that TrkB inhibition may represent a promising novel anti-tumor therapeutic strategy. This hypothesis is currently being evaluated in clinical trials. Here, we will discuss the latest developments on TrkB in these contexts as well as highlight some critical questions that remain to be addressed for evaluating TrkB as a therapeutic target in cancer. Received 12 October 2005; received after revision 19 December 2005; accepted 11 January 2006     

Lipid-lowering drugs

Although a change in life-style is often the method of first choice for lipid lowering, lipid-lowering drugs, in general, help to control elevated levels of different forms of lipids in patients with hyperlipidemia. While one group of drugs, statins, lowers cholesterol, the other group, fibrates, is known to take care of fatty acids and triglycerides. In addition, other drugs, such as ezetimibe, colesevelam, torcetrapib, avasimibe, implitapide, and niacin are also being considered to manage hyperlipidemia. As lipids are very critical for cardiovascular diseases, these drugs reduce fatal and nonfatal cardiovascular abnormalities in the general population. However, a number of recent studies indicate that apart from their lipidlowering activities, statins and fibrates exhibit multiple functions to modulate intracellular signaling pathways, inhibit inflammation, suppress the production of reactive oxygen species, and modulate T cell activity. Therefore, nowadays, these drugs are being considered as possible therapeutics for several forms of human disorders including cancer, autoimmunity, inflammation, and neurodegeneration. Here I discuss these applications in the light of newly discovered modes of action of these drugs. Received 5 September 2005; received after revision 29 December 2005; accepted 26 January 2006     

人因分析:需要、问题和发展趋势

论述了人因分析对人机系统的合理设计、特别是对提高系统可靠性、安全性的重要意义 ,界定了系统人因分析概念的涵义 ,提出了人因分析学科在理论与应用方面面临的九大问题 :人因分析的难度 ;对人因的再认识——个体、群体、组织 ;环境与人行为的关系 ;人员可靠性分析 ( HRA)方法 ;人误机理 ;客观性与一致性 ;数据的可用性 ;文化因素 ;组织管理层的人因分析 .最后从理论与应用两方面讨论了人因分析学科近期应发展的三个范畴 :人因分析基础研究 ;人 -机系统设计指导 ;安全评价与事故防范 .     

中国人力资源时空结构变化分析

简介了人力资源的基本内涵，在分析国内外既有文献的基础上，论述了中国人力资源演谱的基本特征：人力资源丰富，正处于开发的好时机；劳动适龄人口呈较快的增长势头；劳动力文化水平逐步提高，但整体水平仍较低；分析了中国人力资源的城乡结构和省城结构，均表现出不均衡的发展态势，探讨了中国人力的开发利用对策。     

和谐审美的当代实践意义

和谐是审美理想的最高形态。和谐美以其作为审美精神指向对生活的引领作用和审美功能优势,在启迪美学学科建设、引领现实生活向理想境界提升、促进人的和谐发展、构建和谐世界和谐社会、协调人与自然的关系等当代实践中,有着十分重要的意义。     

论事业单位人力资源管理效率与绩效考核

在分析事业单位功能的基础上,针对事业单位人力资源管理的共性问题,探讨绩效考核作为激励机制的核心行为,以中等职业学校为案例,提出提高人力资源管理效率的具体做法。     

2′-脱氧胞苷探针测定血清样品中蛋白质含量

白蛋白在血浆总蛋白中占有很大的比例,高达40%~60%,它在人体内起着至关重要的作用,可以通过分析蛋白质的含量来反映人体的健康状况.人血清白蛋白表面具有多样化的结合位点,2′-脱氧胞苷能够与人血清白蛋白(HSA)相结合,但由于这种结合改变了HSA的结构,其荧光性质也就随之发生了改变.发明了一种新的测定蛋白质的方法,用2′-脱氧胞苷作荧光探针分子结合固定波长同步荧光光谱法对蛋白质的含量进行分析.在一定的条件下,当HSA的浓度满足在1.38~276μg·mL-1这一条件时,溶液的同步荧光强度(ISF)与HSA的浓度具有确定的线性关系.通过测定11份空白溶液发现检出限为0.024μg·mL-1(n=11).对实验条件进行了探究,发现溶液的pH值、扫描波长的变化量(Δλ)、试剂的加入顺序以及溶液的离子强度等因素都会影响体系荧光光谱特征及强度.还测量了人血清中的蛋白含量,回收率在98.4%~104.3%范围内.     

先秦儒家伦理性财富观的人文主义启示

先秦儒家的代表孔子、孟子和荀子在"百家争鸣"的过程中,通过对义利关系的阐述提出了他们的伦理型财富观,从个人的角度提出重义轻利,取之有义;从统治阶级的角度提出义以生利,先义后利,以义制利,见利思义,表达了他们对于个体生存的重视和个人价值的理性思考和推崇,以及寻求社会和谐的人文主义关怀。