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Jin Yan Cheng He Changlin Lu Chenghai Wang Xuan Bao Tieshan Tang Xiuying Huang Fangzhen Sun 《科学通报(英文版)》2001,46(6):477-480
The action of ciliary neurotrophic factor (CNTF) on intercellular free Ca2+ concentrations [Ca2+]i induced by glutamate (Glu) in primary cultured hippocampal neurons were detected with Fura2/AM, a Ca2+-sensitive fluorophore, and the morphological influence of G-protein on it was objected. Glu could induce rapid increase of [Ca2+]i in hippocampal neurons. CNTF had no significant action on [Ca2+]i in resting hippocampal neurons. However, after incubation of CNTF for 5 min, the increase of [Ca2+]i in hippocampal neurons rapidly induced by Glu was inhibited. Pretussis toxin (PTX)-sensitive G protein could block the action. These results indicate that a new non-genomic rapid sideway might exist in the upper stream of CNTF signal transduction pathway, which was related to Ca2+ signal transduction. Keywords: 相似文献
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对近年来视黄素受体介导视黄素抗癌作用机理的研究进展作一综述,主要有:1)视黄素受体;2)视黄素受体与细胞生长;3)视黄素受体与孤生受体的的相关性;4)视黄素受体对AP-1活性的抑制作用;5)视黄素受体介导的信号转导途径。通过研究,对于探讨视黄素受体的功能、阐明视黄素的抗癌机理、合成更多的受体选择性视黄素具有重要的现实意义。 相似文献
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Introduction Rapid adaptation to environmental challenges is vitally important for bacterial survival and growth. One way in which bacteria control their response to changing environmental conditions is through the mechanism of two-component signal transd… 相似文献
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把体细胞胚胎发生现象看作开展生物学理论研究的良好模型,介绍了运用细胞生物学和分子生物学的原理与技术进行研究的成果,特别是体细胞胚胎发生相关基因的研究进展。 相似文献
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A patch clamp chip, as a novel cell-based chip for electrophysiological recordings, has many prominent advantages such as high resolution, accuracy, high throughput and automation. It can be used to perform multivariate and real-time measurements of cell networks in situ. Therefore, this technology will dramatically promote the research on ionic channels, neuronal networks and the application of this technology in drug screening. This paper reviews the development of planar patch clamp technology and its applications in detail. The latest progress in the research of taste cells electrophysiology and taste transduction is also presented. Finally, this paper analyzes the methodology of neural chips. Based on the current research of our laboratory, the prospective applications of a patch clamp chip in the research of taste sensation and transduction mechanisms at molecular and cellular levels are discussed. 相似文献
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