多层标准厂房设计探讨

本文通过多层标准厂房设计,探讨了建筑参数统一化的有关问题。研究结果表明,对于电子、轻工和机械等类型的建筑物推荐柱网尺寸为(8+8+8)m×6m,生活辅助部分为尽端独立单元式。     

微生物发酵过程的细胞密度在线检测与底物浓度实时控制

在许多的微生物发酵和培养过程中,控制碳源(葡萄糖)是实现过程优化的关键.但是葡萄糖等碳源电极价格昂贵,且不能在线灭菌,限制了其应用范围.基于电容法测量细胞密度可以在线灭菌,与细胞干重、OD(光密度)值等生物指标有很好的对应关系,本文实现了基于动力学模型用细胞密度检测数据对发酵底物浓度的预测控制.用遗传算法建立的微生物反应过程动力学模型对分批发酵过程有较好的模拟效果.几次发酵结果对比表明,本文的方法可有效提高目的产物的产量,对制药、食品等工业发酵具有借鉴意义.     

基于小波变换与野草算法的细胞图像特征提取与识别

本文在细胞图像小波多尺度分解的基础上,提出在小波域中进行细胞图像特征提取的方法。针对基于小波变换提取的细胞图像特征向量维数过大、冗余等问题,提出一种基于小波变换与野草优化算法相结合的细胞图像特征的提取方法,最后利用BP神经网络作为分类器进行细胞图像识别。计算机实验仿真结果表明,与现有的未进行特征优化的细胞图像特征提取识别方法相比,本文细胞图像特征提取、分析、识别方法所需时间更短,识别正确率更高,实时性、鲁棒性能更好。     

Selective Smoothed Finite Element Method

The paper examines three selective schemes for the smoothed finite element method (SFEM) which was formulated by incorporating a cell-wise strain smoothing operation into the standard compatible finite element method (FEM). These selective SFEM schemes were formulated based on three selective integration FEM schemes with similar properties found between the number of smoothing cells in the SFEM and the number of Gaussian integration points in the FEM. Both scheme 1 and scheme 2 are free of nearly incompressible locking, but scheme 2 is more general and gives better results than scheme 1. In addition, scheme 2 can be applied to anisotropic and nonlinear situations, while scheme 1 can only be applied to isotropic and linear situations. Scheme 3 is free of shear locking. This scheme can be applied to plate and shell problems. Results of the numerical study show that the selective SFEM schemes give more accurate results than the FEM schemes.     

一种动态数据网格副本创建策略设计与仿真

数据网格提供了地理分布的大量共享数据资源,然而互联网的高访问延迟降低了数据访问的效率,创建副本是一个有效的方法,而在何处放置副本是一个具有挑战性的问题.从应用环境和用户访问特征出发,讨论了副本创建位置、粒度和时机,提出了一种基于副本共享组的副本创建模型,可以获得优化的副本创建位置,构造了一个副本创建代价函数,由系统的传输速率、拓扑结构和用户访问特征共同决定.并给出了确定副本创建位置的有效算法.分析和仿真实验表明,自适应副本管理方案具有动态性、适应性和可扩展性,能较好地适应数据网格的特性,可以有效降低访问延迟,提高数据访问效率.     

基于自适应网格的多目标粒子群优化算法

针对现有多目标进化算法计算复杂度高,搜索效率低等缺点,提出了基于自适应网格的多目标粒子群优化(AGA-MOPSO)算法,其特点包括:评估非劣解集中粒子密度估计信息的自适应网格算法;能够平衡全局和局部搜索能力的基于AGA的Pareto最优解搜索技术;删除非劣解集集中品质差的多余粒子以维持非劣解集在一定规模的基于AGA的非劣解集截断技术.仿真计算表明,和文献中典型的多目标进化算法比较,AGA-MOPSO算法在求解复杂大规模优化问题方面表现了良好的性能.     

Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis

Cancer cells are typically characterized by apoptosis deficiency. In order to investigate a possible role for the anti-apoptotic livin gene in renal cell cancer (RCC), we analyzed its expression in tumor tissue samples and in RCC-derived cell lines. In addition, we studied the contribution of livin to the apoptotic resistance of RCC cells by RNA interference (RNAi). Livin gene expression was detected in a significant portion of RCC tumor tissue specimens (13/14, 92.9%) and tumor-derived cell lines (12/15, 80.0%). Moreover, targeted inhibition of livin by RNAi markedly sensitized RCC cells towards proapoptotic stimuli, such as UV irradiation or the chemotherapeutic drugs etoposide, 5-fluorouracil, and vinblastine. These effects were specific for livin expressing tumor cells. We conclude that livin can contribute significantly to the apoptosis resistance of RCC cells. Targeted inhibition of livin could represent a novel therapeutic strategy to increase the sensitivity of renal cancers towards pro-apoptotic agents. Received 30 November 2006; received after revision 22 February 2007; accepted 20 March 2007     

Receptor communication within the lymphocyte plasma membrane: a role for the thrombospondin family of matricellular proteins

Lymphocytes, the principal cells of the immune system, carry out immune surveillance throughout the body by their unique capacity to constantly reposition themselves between a free-floating vascular state and a tissue state characterized by migration and frequent adhesive interactions with endothelial cells and components of the extracellular matrix. Therefore, mechanisms co-ordinating adhesion and migration with signals delivered through antigen recognition probably play a pivotal role for the regulation of lymphocyte behaviour and function. Endogenous thrombospondin-1 (TSP-1) seems to be the hub in such a mechanism for autocrine regulation of T cell adhesion and migration. TSP-1 functions as a mediator of cis interaction of vital receptors within the T lymphocyte plasma membrane, including integrins, low density lipoprotein receptor-related protein, calreticulin and integrin-associated protein. Received 1 June 2006; received after revision 28 June 2006; accepted 11 October 2006     

地磁感应地电场时频变换快速计算方法

随着中国特高压输电线路的建设,中国电网建设遭受地磁感应电流(geomagnetically induced current, GIC)影响的风险将大大增加。基于大地电阻模型利用有限元计算地磁扰动感应地电场(geomagnetic disturbance, GMD)地电场的方法,建模复杂,利用有限元法计算感应地电场成本过高。地磁测深数据得到的视电阻率综合反映了大地的电性结构,现提出基于视电阻数据及地磁台实测数据直接计算GMD地磁感应地电场的方法。仿真实验表明,该方法可以极大缩短计算时间,减小计算成本,对中国电网应对地磁暴侵害提供了有效算法。计算结果表明地磁暴对各地地电场的影响不均匀,与当地的地质电性结构有很大的关系,同时南北走向的电网将产生更大的GIC,更易受到地磁暴的侵害,应作为主要的关注对象。