Evaluation of the hepatotoxicological effects of a drug in an in vivo/in vitro model

Both in vivo and in vitro models have certain disadvantages for the study of the chronic hepatotoxicity of drugs. The aim of this work was to evaluate a new approach based on an in vivo/in vitro model. After chronic in vivo treatment of rats with Vincamine and Vindeburnol (an eburnamenine derivative which exhibits hepatotoxic properties in man) liver cells were isolated, and functional and metabolic disorders (metabolic utilization of fructose and protein biosynthesis) were studied to determine injury. The results showed no modification of blood parameters, but a direct relationship between the dose of Vindeburnol administered in vivo and the metabolic disorders observed in vitro, evidencing the high sensitivity and reliability of this model.     

The Development and Application of Combined Thermoregulatory Mathematical Models

Thermoregulatory mathematical models have being developed for more than half a century and obtained more and more wide application. Among them, the "engineering-physiological" thermal models, which correlated closely to the man-machine-environment system, are the ones that developed most rapidly and have been widely accepted by thermal physiologists and environmental control engineers.This paper attempts to outline briefly the development and application of such kind of thermal models, discusses how to further develop and apply various combined thermal models in practice, and puts forward four respects of suggestions for establishment and modification of combined thermal models of man-clothing-cabin environment.     

催化重整生焦动力学模型的研究 I.生焦动力学模型的建立

在催化重整１６集总动力学模型的基础上,假设同类反应的失活函数是相同的,建立了生焦动力学模型。在排除了内外扩散等影响因素的前提下,确定了催速生焦失活反应条件和催化剂活性评价条件,使在实验室进行生焦动力学模型的研究成为可能。     

冷带轧机液压厚控系统动态数学模型分析与测试

分析了液压厚度控制系统动态数学模型．并与频率特性测试仪所测结果做了比较．得出了实用的被控对象结构图．为厚度控制系统的设计提供了理论依据．     

航空军械综合系统维护的半马尔可夫模型

以航空军械综合系统的多状态维护过程为研究对象,对其建立了半马尔可夫的数学模型。在系统维护的等待阶段,运用阶段以及交替阶段中运用该模型,得到了系统在各个不同状态的概率及有效性指数。这些结果对维护实践具有重要的指导意义。     

大学基础数学教学中高层次人才的培养

论述了在大学基础数学对高层次人才培养的要求,高层次班的教学内容,教学方法,并进行了高层次班教学内容与教学质量的分析。     

尿激酶亲和层析分离中吸附和洗脱过程的速率模型模拟

采用非平衡层析速率模型，对尿激酶的亲和层析过程进行了模拟计算。利用亲和层析，可以将粗品原料净化为高纯度尿激酶产品；层析所用的亲和载体是采用对氨基苯甲脒作为配基，将琼脂糖凝胶进行活化制得的。通过问歇实验，测定了吸附等温线并进行吸附动力学研究。借助于VERSE—LC模拟软件，采用速率模型作为基本方程，对亲和层析的实验现象进行了数值模拟分析，与实验结果进行对比发现，速率模型可以较准确地描述固定床中的亲和层析过程。     

模糊神经网络在石油压裂支撑剂研制中的应用

石油压裂支撑剂的研制是一项复杂有难度的技术，受到很多因素的影响。针对研制过程中各项指标具有较大模糊性的特点，应用模糊神经网络系统(FNNS)来获取各影响因素与支撑剂质量的关系模型和预测模型，从而找到原料配比、成球工艺参数、烧结温度与产品质量之间的最佳关系。     

基于模拟退火算法的子集AR模型辨识方法及其应用

该文提出一种子集ＡＲ模型辨识算法，该方法采用模拟退火随机搜索算法，对模型的回归项子集进行优化辨识，克服“组合爆炸”问题，简化计算。文中还讨论了基于该算法的人口死亡率建模和预报问题。