Src activation and translocation from focal adhesions to membrane ruffles contribute to formation of new adhesion sites

Cell migration requires the coordinated turnover of focal adhesions, a process that involves FAK phosphorylation. Since Src is the major kinase implicated in FAK phosphorylation, we focus here on the role of Src activation on adhesion remodelling. In astrocytoma cells, constitutively activated Src induces both FAK phosphorylation and adhesion rearrangement. To evaluate how Src controls these processes, we used a recently described Src reporter to monitor the dynamics of Src phosphorylation. Upon Src activation, focal adhesions started to disassemble while Src appeared highly expressed at newly formed membrane ruffles. Kinetic analysis of time-lapse movies showed that loss of phospho-Src at focal adhesions was time-correlated with the appearance of membrane ruffles containing phospho-Src. Moreover, FLIP analysis revealed a dynamic equilibrium of Src between focal adhesions and membrane ruffles. We conclude that upon phosphorylation, Src is directly translocated from focal adhesions to membrane ruffles, thereby promoting formation of new adhesion complexes. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users. Received 21 July 2008; received after revision 10 October 2008; accepted 03 November 2008     

Focal and segmental glomerulosclerosis

An increasing cause of end-stage renal disease is the pathological lesion focal and segmental glomerulosclerosis (FSGS). FSGS is characterized by proteinuria and frequently nephrotic syndrome with ensuing renal failure. The etiology remains unknown in the majority of individuals. The idiopathic form of FSGS is most common; however, secondary forms of FSGS do exist. There is a form of FSGS that is fulminant that frequently recurs after renal transplantation with an estimated frequency of approximately 30%, suggesting that the pathogenesis is not solely a result of intrinsic kidney disease. Recently, hereditary forms of the disease were recognized as well as those associated with other congenital syndromes. Known genetic causes of the hereditary form of this disease have been suggested to account for upwards of 18% of cases. This review will address recent discoveries of the genetic mechanisms of hereditary FSGS and the current interpretations of their interactions at the slit diaphragm. Received 17 April 2006; received after revision 23 May 2006; accepted 6 July 2006     

关系数据库中的空值与数据依赖

论证了关系数据库中的空值与数据依赖及其满足性的问题．     

正纯函数的正规族和Picard例外值

在文中,得到亚纯函数的正规族和Picard例外值方面的几个结果。     

土壤初始温度模型

通过热传导理论,建立了地下土壤初始温度分布的理论计算模型,并将模型的全年模拟结果与全年实测值进行了对比.结果表明,地下土壤温度分布模型的计算值与实测值十分吻合,说明理论模型是正确的.模拟结果表明,当土壤深度达到10 m时,土壤全年温度趋于稳定.该理论模型可应用于土壤源热泵系统的分析和设计中.     

代数体函数的拟Borel例外值及其唯一性

研究了代数体函数的一类例外值-拟Borel例外值并得到其相关性质,并将亚纯函数的一个唯一性定理推广到代数体函数.     

多元函数取极值的一阶充分条件

将一元函数取极值的一阶充分条件推广到多元,提供了判定多元函数的极值的１个有效方法。     

新疆城乡居民体育生活认知及条件

为有的放矢地落实民族地区“全民健身计划”提供真实、有效的材料及对策依据,对新疆维吾尔族自治区城乡居民全民健身活动进行了调查．通过分析得出,在区域文化氛围中,特别是具备积极保健意识和良好卫生习惯的伊斯兰教影响下,新疆城乡居民表现出正确的体育价值观和积极的体育生活态度;以“动”为主的闲暇文化是充裕闲暇时间的主旋律;良好的经济大环境为新疆的体育事业提供着强大的支持．但个人经济水准尚要求体育生活以“少花钱多办事”为原则．建议政府及其职能部门充分利用信息手段,强化居民的健身意识;拓展工作思路,改变管理方式;全方位地以健康、文明的生活内容占领闲暇文化市场;引导经济投入向保证社会可持续发展的人力资源方向转移;合理利用宗教中的体育成分,为健身活动提供动力．     

既约随机矩阵

该文给出了既约随机矩阵的关于谱和特征值的若干性质,２个既约随机矩阵Ｋｒｏｎｅｃｋｅｒ积的性质,既约双随机矩阵乘积和幂的性质,给出矩阵的幂是既约矩阵的充要条件。该文研究了Ｆ族中矩阵的特征值特征向量和谱半径等有关性质     

亚纯函数与其导数具有一个公共值的几个进一步结果

研究了亚纯函数与其导数具有一个非零有限公共值的唯一性问题.得到了一些结果,例如f,f′以非零有限值a为CM(DM)公共值,如果