The in vivo expression of the globin genes of theβ cistron in γ-,δ-, andδβ-thalassemia heterozygotes

There is considerable evidence suggesting that the switch from to and chain production after birth is due, in part, to silencing of the genes by stage-specific factors which bind to their promoters and to the competition from the adult ( and ) genes for a common enhancer element located in the locus control region. As a consequence one can expect that the increased Hb F production in adults with hereditary persistence of fetal hemoglobin or -thalassemia is directed mainly by -globin genes in cis to the deletion(s) responsible for these conditions. Here we review data on heterozygotes with -, -, or -thalassemia, who also had an^AT mutation, in cis or in trans, which was used as a marker of gene expression. The results show that a deletion affecting adult genes favors the expression of genes in cis, while the deletion of a single gene does not affect the expression of the gene in cis but leads to a faster switch postnatally.     

Detection of toxic metabolites in the hemolymph ofBeauveria bassiana infectedSpodoptera exigua larvae

Highly active metabolites have been detected in the hemolymph of the lepidopteranSpodoptera exigua infected with the mycopathogen,Beauveria bassiana. A combination of phenyl sepharose and CM ion exchange chromatography was utilized to extract the active metabolites from infected hemolymph samples. The active in vivo metabolites, having a molecular mass greater than 10 KDa, were thermolabile and were inactivated by proteinase K. These metabolites were characterized by their ability to disrupt metamorphosis, killing treated larvae at the wandering or pupal stage. Additionally, injection ofS. exigua larvae with active samples caused a reduction in the number of filopodial-producing hemocytes. The biological activities and biochemical properties suggest that novel compounds are produced duringB. bassiana mycosis.     

普通物理课程与“现代化”教学之探索

本文就大学普通物理课程与现代化的两个主要矛盾:学时与内容,内容与现代化,结合教学加以探索。     

车前的离体培养和植株再生

报道了国丧外植体的愈伤组织诱导及其植株再生的研究结果,单独的外源生长素２,４－Ｄ适宜诱导外植体脱分化产生愈伤组织。再生芽的分化只需添加６－ＢＡ;当ＮＡＡ与６－ＢＡ配合添加于培养基中时,则有利于再生根的繁茂生长,从而形成完整的再生植株。     

非线性电路故障诊断的可测性研究

本文是关于非线性模拟电路故障诊断的测试点选择问题的研究,在本文提出的关于诊断方程的雅可比矩阵的物几乎处处恒等这一概念的基础上,研究了非线性情况下诊断方程的形式及其可测性问题。     

秦淮河流域典型排涝泵站前池水质与降雨特征响应关系

为分析排涝泵站前池水质与降雨特征的响应关系,对南京市城区秦淮河沿线2个排涝泵站前池水质以及降水量开展高频在线自动监测,结合回归树方法分析了不同降雨强度、前期干旱时间条件下排涝泵站前池水质变化规律,探讨了不同类型排涝泵站前池水质的主要影响因素。结果表明:晴雨天均有生活污水汇入的A泵站前池氨氮质量浓度在大雨强下降低,中雨强下先升高后降低,小雨强下平缓上升,A泵站前池污染物质量浓度主要受降雨强度和次降水量影响;主要接收降雨径流,雨量大时有生活污水溢流汇入的B泵站,前池污染物质量浓度在大雨强下先升高后逐渐降低,中雨强下降低,小雨强下变化不大,B泵站前池水质主要受次降水量、前期干旱时间和降雨强度影响;2个泵站前池CODMn质量浓度变化与降雨的响应规律相似,但更多受到与前期干旱时间关联的地表径流冲刷作用影响;连续降雨均导致泵站前池氨氮质量浓度和CODMn质量浓度波动变化较大,而前期干旱时间越长,降雨发生后泵站前池水质越差。     

高阶微分中值定理及其应用

利用向量形式的微分中值定理,把一阶微分中值定理推广到全新的高阶微分中值定理,并研究了它的应用．     

Bernstein多项式导数的整体收敛速度

研究Ｂｅｒｎｓｔｅｉｎ多项式的导数对可导函数的整体逼近,利用Ｋ－泛函和光滑模的方法,建立了同时逼近的正定理和逆定理     

一个新的单调类定理

定义了集类的ｗ类的概念,给出了ｗ类的单调类定理．     

关于人造天体运动轨迹确定的一种方法

作者在该文中,从万有引力定律出发,根据有心力的特点,再采用切坐标法很方便地推导出在地球万有引力作用下,人天体运动的轨道必是圆锥曲线,并指出由发射时初始条件能方便地进一步确定其轨迹的形状。