A NEW DESCRIPA NEW DESCRIPTOR OF AMINO ACIDS BASED ON THE THREEDIMENSIONAL VECTOR OF ATOMIC INTERACTION FIELD

QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) IS A VERY IMPORTANT TOPIC FOR MANY SCIENTIFIC FIELDS AND CAN BE TERMED AS QUANTITATIVE SEQUENCE ACTIVITY MODELS(QSAM)[1] WHEN REFERRED TO THE RESEARCH ON RELATION- SHIPS BETWEEN STRUCTURES AND ACTIVITIES OF BIOLOGICAL MOLECULES, SUCH AS PROTEINS, AND NUCLEIC ACIDS. HOW- EVER, IT IS VERY DIFFICULT TO ESTABLISH A QSAM MODEL,…     

基于隐式梯度模型的混凝土损伤的数值模拟

分析了局部损伤模型在进行混凝土应变软化模拟时存在的问题:网络依赖性和零能量损耗问题;分别应用隐式梯度模型和局部模型对混凝土应变软化进行了模拟。计算表明该隐式梯度模型可较好避免有限元在应变软化模拟时的网络依赖性,预测出的荷载-位移响应与实际情况吻合较好。     

Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

磨料射流切割金属套管机理及计算公式

研究和分析了磨料射流切割机理，由于实际工作中固体颗粒做占比例较小，把磨料两相射流假定为稀疏固液两相流，将固体颗粒假定为伪流体，其运动速度与流体运动速度相同。根据弹性力学的固体接触理论，建立了相应的数学模型，得出了磨料颗粒与材料相接触时的最大接触剪应力公式，从而计算出切割套管所需要的最大剪应力，最后通过实例计算，其结果与现场试验结果相吻合，为该技术不断发展及工艺参数选择提供了理论支撑。     

负债条件下高校财务管理的创新

由于高校大规模的银行负债的出现,高校的经济要素已从财政拨款、事业收费的二元结构转变为三元结构。三元结构改变了高校一系列的经济关系。高校财务管理体系制度因其长期基本不变而日渐示弱。改进这种示弱状态需要在财务管理制度、核算、监管等方面进行管理创新。     

基于模型的飞行控制系统一体化设计技术研究

飞行控制系统设计是一项复杂的系统工程,涉及众多的专业。为了提高系统开发效率,采用MATLAB软件构建了统一的设计平台,使得各专业能够借助平台开展相关设计工作。飞行控制系统一体化设计思路来源于基于模型的设计思想。采用基于模型的设计流程,能够快速完成设计迭代,缩短产品研制周期。作者从飞行控制系统设计的角度,对采用MATLAB软件构建的一体化设计平台及涉及的相关专业技术进行了研究,供广大工程设计人员借鉴。     

E-n-伪矩形性拟正则半群

本文是在[1]的基础上,将半群s的幂等元集E(S)由埋想推广为n-伪理想,然后来给出S的结构。本文未用到格林关系,因而证明有别于[1],而且[1]是我们的特例。     

固定床电化学反应器模型数值求解方法

文中给出描述固定床电化学反应器内两维电势和浓度分布的普遍化数学模型。该模型为具有混和边界条件的抛物线及椭园微分方程组。作者开发一种新的具有正交配置及有限差分二法优点的数值计算方法,求得了这组非线性偏微分方程的解。文中给出该数值方法的细节及计算程序框图。     

外场与腔场非共振驱动Jaynes－Cummings系统的准能解

本文主要求出了Ｊ－Ｃ系统受与腔场非共振的外场驱动时的准能级及态的近似表达式，设外场与腔模的失谐量△_ｃ远小于耦合常数ｇ，并且腔模光子数较小，在计算中可略去。结果可知，失谐量△_ｃ存在使能级中心位置移动，但对能级分裂量没有影响。相应的光场态为两个位移福克态的叠加。     

灰铸铁的应力屈服曲面及其三维热弹塑性应力解析

对原有的灰铸铁件应力屈服曲面进行了合理的简化,使其在理论上合理,工程应用上更为方便。建立了灰铸铁件三维非稳态热弹塑性应力场的有限元方法。以灰铸铁哑铃件为对象,用新屈服曲面对其应力发展过程进行了模拟,且比较了用新旧屈服面计算得到的结果。