Changes in body temperature and circulating levels of interleukin-6 after intra-arterial injections or infusions of tumor necrosis factor α in guinea pigs

Tumor necrosis factor (TNF) is released systematically during the early phase of endotoxin induced fever. To study the effects of this cytokine in guinea pigs, 2 g TNF were intra-arterially injected as a bolus or slowly infused within 60 min. Both modes of administration induced a biphasic elevation of the animals' abdominal temperature lasting 6 h and stimulated the release of endogenous interleukin-6 (IL-6)-like activity. The second phase of the thermal response and the release of endogenous IL-6-like activity were significantly higher, when TNF was slowly infused into the animals' circulation, in spite of a transiently higher TNF-like activity after the bolus injection of TNF. Both TNF and IL-6 may therefore be regarded as candidates to trigger the febrile response in guinea pigs.     

Depletion of hypothalamic norepinephrine reduces the fever induced by polyriboinosinic acid: polyribocytidylic acid (Poly I:Poly C) in rats

Summary Administration of either Poly I:Poly C (0.05–0.50 g) or norepinephrine (2–8 g) into the anterior hypothalamic area produced a dose-related fever in rats. The fever induced by Poly I:Poly C was attenuated after selective depletion of norepinephrine in the hypothalamus. However, selective depletion of hypothalamic norepinephrine did not affect the fever induced by intrahypothalamic norepinephrine. The data indicate that Poly I:Poly C may act to induce fever through the endogenous release of norepinephrine from the rat's hypothalamus.This work was supported by grants from the National Science Council (Taipei, Republic of China).     

云冈热电配煤掺烧经济性研究

随着燃煤价格的不断上扬,发电企业经营压力空前增加。为了减缓生产、经营压力,降低单位燃料成本,需要在保证安全生产的前提下,寻找替代煤源、掺烧低热值煤种,本文重点是对云冈热电配煤掺烧经济性进行研究,通过对煤质特性分析及比质比价分析,公司通过在生产中不断摸索,初步确定了掺烧方案,提高了企业的经济效益。     

重大传染病防治研究领域专利分析 ——以登革热为例

重大传染病严重危害着人类的健康,其中登革热是当今世界流行性最广的蚊媒病毒性传染病,它涉及世界100多个国家和地区,造成每年约3.9亿人感染。针对当前国际和国内登革热的研究现状,从专利分析角度,对其中的专利申请态势、技术构成、主要申请国、主要发明人等都进行了详细的阐述,并深入探究该领域的研究热点和预期的未来走向,本文有利于推进我国在登革热防治工作上的进步与发展。     

日粮阴阳离子间隙和日粮类型对奶牛乳热症的影响

乳热症是奶牛的一种严重代谢性疾病,是现代养牛业常见病、多发病.目前,对于该病的发病机理尚没有完全搞清楚,现在多采用发病后大量补钙来进行治疗,但是在发病时,病情已十分严重,因此临床疗效常常不佳.当前预防奶牛乳热症的方法主要是通过平衡干奶牛日粮离子,日粮阴阳离子间隙(DCAD)便应运而生,它作为定量分析碱源性日粮中的有害成分和饲喂阴离子日粮的有利作用的指标.通过平衡日粮离子,获得适宜的离子间隙,可以极大的改善奶牛的生产性能,有效防止乳热症,提高饲料摄入,增加奶产量,降低跛行、难产、乳房炎的发病率.     

2014年西非埃博拉出血热流行状况与防控研究

自1976年首次发现埃博拉病毒以来,埃博拉疫情在非洲时有报道,而2013年年底开始至今的西非埃博拉疫情正以前所未有的肆虐之势蔓延.截至2014年8月31日,本次疫情共发现病例3 707例,其中死亡1 848例,规模已超过既往各年疫情的总和.针对该病,目前仍无正式上市的特效药物和疫苗,但WHO已允许临床试验药物和疫苗在西非疫情中的干预研究.鉴于此,需要在优化卫生资源配置的基础上,针对传染病传播的3个基本环节进行全面防控,同时在"惟一健康(One Health)"的框架下,通过公共卫生与兽医领域的专家的共同合作,从源头上控制疫情的发生和发展.     

肾综合征出血热的腹部CT表现

为探讨肾综合征出血热(HFRS)的腹部CT表现及临床意义,特搜集经本院临床确诊的HFRS,并行腹部CT扫描患者 10例,其中双肾明显肿大 6例,肾包膜下出血1例,肾周积液3例,腹水6例,胆囊炎4例,双侧胸腔积液6例.通过CT扫描,及早发现病情,尤其是疑有肾破裂出血做CT扫描,具有特异性诊断,给临床提供准确的诊断,充分发挥影像学在HFRS诊断治疗中的作用,更好地为临床服务.     

发热信号传导途径及诊断程序研究

目的研究发热防治新原则和感染性发热诊断新程序。方法运用医学统计学原理,对开放性学术信息综合分析。结果多种致热性细胞因子和负调节介质共同作用,使机体温核集团对致热原作用发生指向性调控。讨论外源性致热原通过神经介质、致热性细胞因子及内源性致热原作用体温中枢,最终导致体温升高。     

流行性出血热病毒的细胞培养

用灭活的流行性出血热病毒（EHFV）L99株感染传代培养的Vero-E6细胞,第4d50%的Vero-E6细胞浆内可查到对EHFV鼠血清的特异性荧光,第7-10d阳性细胞数达到100%。用感染第3d的细胞培养上清大批量盲种,第7-10d荧光强度均达到 ,电镜下病毒呈圆形或卵圆形,外膜为电子致密层,界面清楚,包绕着比较疏松的内浆,内浆中有若干个颗粒丝状结构。     

Sequencing and rescuing a highly virulent classical swine fever virus： Chinese strain cF114 from a full-length cDNA clone

Classical swine fever is an economically important, highly contagious disease of pigs caused by the classical swine fever virus (CSFV), as referred to as hog cholera virus. CSFV belongs to Pestivirus within the family of Flaviviridae. The virus contains a positivestranded RNA of approximately 12.3 kb in length[1]. The genome is composed of a 5′ non-coding region, a single large open reading frame (ORF) encoding the viral polyprotein with 3898 amino acid residues and a 3′ non-coding reg…