The epidermal growth factor receptor family: Biology driving targeted therapeutics

The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors carry out both redundant and restricted functions in mammalian development and in the maintenance of tissues in the adult mammal. Loss of regulation of the ErbB receptors underlies many human diseases, most notably cancer. Our understanding of the function and complex regulation of these receptors has fueled the development of targeted therapeutic agents for human malignancies in the last 15 years. Here we review the biology of ErbB receptors, including their structure, signaling, regulation, and roles in development and disease, then briefly touch on their increasing roles as targets for cancer therapy.     

香草醛缓释剂的合成和水解性能的测定——一种长效植物生长激素

以DMSO为溶剂、对甲苯磺酸或浓硫酸作催化剂,由聚乙烯醇和香草醛制备了聚乙烯醇缩香草醛,其缩醛度可达55%。室温下该缩醛可水解而缓慢释放出香草醛。     

中国经济增长的可持续研究——一个制度、技术与要素增长角度的分析

采用柯布.道格拉斯生产函数模型,通过经济增长核算的分解,发现:中国的经济在1979年发生结构突变。1978年改革前的26年,技术进步停滞不前,甚至是退步的。改革后技术进步对经济增长的影响不显著。中国改革开放后经济高速增长主要是投资高速增长驱动的,是粗放式经济增长。中国经济要持续快速发展,必须更加注重技术对经济增长的贡献率。     

科技投入对江苏省经济增长的影响研究

基于江苏省时间序列及面板数据模型,计量检验了科技投入对江苏省经济增长的影响机制。结论表明：①改革开放前,江苏省的经济增长主要依靠劳动力投入;改革开放后,则主要依靠资本投入,科技投入的整体贡献有待提升。②在苏南等科技发达地区,科技投入对经济增长的贡献已经高于资本积累,成为经济增长的第一要素;但在苏中、苏北地区,经济增长依然主要依靠资本投入。     

Ni在Ni(100)面的薄膜生长的蒙特卡罗模拟

采用晶格动力学蒙特卡罗(KLMC)方法模拟Ni在Ni(100)面的薄膜生长,对原子的沉积、吸附、扩散、成核、生长等微观过程采用了合理的模型,研究基板温度和沉积速率对薄膜的生长形貌和表面粗糙度的影响.模拟结果表明:沉积在基板上的原子逐步由各个离散型变成紧致型的近四方形的岛,并由二维向三维岛转变,最后连接成膜;基板温度越高,沉积速率越低,生成的薄膜越平整,粗糙度越小;沉积速率一定,表面粗糙度随着基板温度的增加而减小,当基板温度达到一定值时粗糙度降为零.     

碳钢连铸凝固过程的微观模拟

通过一种简单的数学模型研究了连铸坯凝固过程中枝晶生长的重要微观结构参数.结合中碳钢连铸性能计算出凝固过程中枝晶生长的尖端半径、枝晶生长速率、二次枝晶臂间距等枝晶相关参数,并研究了拉速对上述微观结构参数的影响.分析了碳、硅、锰、磷和硫等重要元素的微观偏析程度随凝固进程与坯壳生长的变化规律.与前人经验模型的对比与验证表明本文模型预测结果合理.     

Anthropogenic climate change revealed by coral gray values in the South China Sea

The authors analyze the coral growth band from a colony in the northwestern South China Sea. The coral growth band can provide comprehensive environmental information on climate. The trend from the two-century-long annual density of the coral is in a good agreement with that of the global CO2 concentration. Both trends were small prior to the end of the 19th century; after that, trends became clear, more so from the 1960s to the 1990s (the end of the coral record). The overall coral density shows a steady d...     

经济增长对劳动力需求的结构分析

为定量地评价人力资源对国民经济发展的贡献，分析人力资源对国民经济增长的影响，合理地制定国民经济发展过程中人力资源开发和利用计划．本文依据ＤＥＡ理论和方法，建立了评价人力资源对国民经济发展贡献的ＤＥＡ模型．并依据该模型，分析和确定了中国未来和近期经济发展对劳动力需求的指标和人力资源发展战略方案．     

Lateral growth of silicalite-1 crystal membrane on glass slabs

Conclusions By the control of hydrothermal synthesis, lateral-oriented silicalite-1 membrane was synthesized on a glass slab, which posseses uniform aligned nano-channels in a large scale and results in a new host material for the study host-guest science.     

基于生长的等级人才系统的宏观分析

本文采用定量的模型化技术和定性的经验知识相结合的方法，基于内部生长特性，对复杂的等级人才系统进行了宏观研究，建立了系统模型，分析了人才结构的熵特性，并开发了一个实用的等级人才预测规划辅助决策系统．