药用辅料——高分子聚合材料测定方法的正交试验

设计正交试验,建立药用辅料——高分子聚合材料测定方法.以L9(34)正交试验考查该方法的4个重要因素及水平.确立方法后按2010年中国药典要求做方法学研究.结果表明:该法检测的线性范围为2～100μg.mL-1;r=0.999 8;检出限为0.5μg.mL-1;该方法的平均回收率为0.96;日内RSD为0.02.该方法符合2010年中国药典关于杂质限量检测方法的规定,是检测此类PLLA辅料中乳酸含量的可行方法.     

原白头翁素的提取,合成及保存研究

从白头翁(Pulsatilla Chinesis)植物中提取与人工合成了毛莨科植物含有的原白头翁素和白头翁素.经UV、IR、NMR、MS 等光谱分析鉴定,结构正确.经果蝇、水稻白叶枯病菌等生测试验表明,原白头翁素具有杀虫活性和显著的抑菌活性.原白头翁素聚合后,生物活性明显降低.     

敦化泥炭矿物质组成的研究

选取敦化大桥和哈尔巴岭两个泥炭剖面，在实验室测定了泥炭矿物质组成及其剖面变化情况，并与吉林省东部其他泥炭剖面进行对比。结果显示：泥炭灰分含量远远低于同一剖面其下部矿质土的灰分含量；同一地区、同一成炭植物类型，因成矿类型不同，灰分含量有差异；与其他地区泥炭相比，敦化泥炭属于中等偏低灰分泥炭；灰成分中Na2O含量偏高。     

作为智能催化剂的电驱动高分子的分子设计

将组氨酸以共价键连接到酰氯化的聚丙烯酸分子网络上 ,设计合成作为智能高分子催化剂的聚丙烯酰胺支载咪唑基化合物 .将此类电响应高分子催化乙酸 p -硝基苯酯的水解反应 ,用荧光分光光度计跟踪监测反应的进程 ,分析在一定频率的电场刺激响应下不同交联密度对催化活性的影响 .     

无毒防锈颜料亚磷酸－磷酸钾锌的聚合及防锈性能研究

无毒防锈颜料亚磷酸－磷酸钾锌经高温处理生成聚合亚磷酸－磷酸钾锌，ＩＲ、Ｘ－ｒａｙ、ＤＴＡ、ＴＧＡ等测试证实了聚合物的形成．测定了它们的技术指标及漆膜性能、聚合物的防锈性能明显优于亚磷酸－磷酸钾锌．     

氨基酸及其黄变产物对染料光褪色的影响

本文通过荧光法的类 Stern-Volmer 方程,采用紫外光谱和循环伏安法等实验手段,初步研究和探讨了真丝上染料光褪色机理和真丝的化学成份对染料光褪色的影响.发现染料光褪色与构成真丝的氨基酸种类有关.构成真丝的十八种氨基酸中的色氨酸和它的黄变产物能显著加速染料光褪色,酪氨酸和它的黄变产物也有促进染料光褪色作用。     

Profiling of the secreted proteins during 3T3-L1 adipocyte differentiation leads to the identification of novel adipokines

Adipose tissue is an endocrine organ capable of secreting a number of adipokines with a role in the regulation of adipose tissue and whole-body metabolism. We used two-dimensional gel electrophoresis combined with mass spectrometry to profile the secreted proteins from (pre)adipocytes. The culture medium of 3T3-L1 cells during adipocyte differentiation was screened, and 41 proteins that responded to blocking of secretion by 20°C treatment and/or brefeldin A treatment were identified. Prohibitin, stress-70 protein, and adhesion-regulating molecule 1 are reported for the first time as secreted proteins. In addition, procollagen C-proteinase enhancer protein, galectin-1, cyclophilin A and C, and SF20/IL-25 are newly identified as adipocyte secreted factors. Secretion profiles indicated a dynamic environment including an actively remodeling extracellular matrix and several factors involved in growth regulation.Received 15 June 2004; received after revision 26 July 2004; accepted 2 August 2004     

Perfluoroalkyl substances in the blood samples from a male population of Sweden

Temporal trends of perfluoroalkyl substances （PFASs） have been determined in the blood samples from several countries globally including a female population in Sweden recently, yet little is known about the time trends in the blood levels of these compounds in Swedish male populations over recent years. In this study, the fourteen target PFASs consisted of four perfluorosulfonates （PFSAs） and ten perfluorocarboxylates （PFCAs） in the whole blood samples, collected from 153 Swedish elderly men during the period between 2008 and 2010, were analyzed via ultra-performance liquid chromatography-tandem mass spectrometry （UPLC-MS/MS）. As the dominant PFASs contaminants in the blood samples, perfluorooctane sulfo- nate （PFOS） showed the highest geometric mean （GM） at 8.5 ng/mL, ranging from 1.7 to 29 ng/mL, while blood perfluorooctanoic acid （PFOA） contained the GM of 1.8 ng/mL, ranging from 0.35 to 6.4 ng/mL. Both the levels of these two compounds were lower than those determined in the blood samples of Swedish elderly pop- ulations derived from the late 1990s. According to the temporal trend analysis, over the three years, the blood levels of PFOS in Swedish male populations declined 16 % per annum, while those of perfluoroundecanoic acid （PFUnDA） increased 6.1% per annum, which were con- sistent with those reported previously for the populations from other countries.     

超亲核催化剂:含烷氨基吡啶功能基团的化合物和聚合物(英)

本文参考了51篇文献，对超亲核酰化反应催化剂4-二烷基氨基吡啶系列化合物和聚合物进行了综述．其中包括：4-（N，N-二甲基氨基）吡啶（DMAP），4-（N，N－二烯丙基氨基）吡啶（DAAP），聚合物负载烷氨基吡啶，烷氨基吡啶高分子化合物等．此外，叙述了该类催化剂的合成及应用．     

Extracellular matrix and neuronal movement

Summary During brain development, both neuronal migration and axon guidance are influenced by extracellular matrix molecules present in the environment of the migrating neuronal cell bodies and nerve fibers. Glial laminin is an extracellular matrix protein which these early brain cells preferentially attach to. Extracellular glycosaminoglycans are suggested to function in restricting neuronal cell bodies and axons from certain brain areas. Since laminin is deposited along the radial glial fibers and along the developing nerve pathways in punctate form, the punctate assemblies may be one of the key factors in routing the developing neurons in vivo. This review discusses the role of laminin in neuronal movement given the present concept of the extracellular matrix molecules and their proposed interactions.