Assessment of alternated cooling and heating treatment by US combined CEUS in the VX2 rabbit liver tumor model

Inoperable liver tumors are often treated by thermal ablation that destroys the tumor in situ and spares the adjacent hepatic tissue.Thermal–physical treatment has many advantages,but treatment by freezing or heating alone has some limitations.By taking the advantages and disadvantages of cryosurgery and thermotherapy into consideration,a new thermal technique that combines cryosurgery and radio frequency ablation has been proposed,thereby overcoming the disadvantages of each treatment strategy and improving therapeutic outcomes.This new approach remains to be systematically studied in the liver;therefore,this study was performed to estimate survival after alternated cooling and heating ablation therapy in a VX2 rabbit liver tumor model.Sixteen days after VX2 carcinoma implantation into the rabbit liver,tumors were treated with alternated cooling and heating ablation therapy.Rabbits were monitored for 6 months after treatment and assessed with ultrasound(US)and computed tomography at 1,7,14,and 30 days posttreatment.Untreated tumor-bearing animals served as the control group.Our results show that alternate freezing and heating ablation therapy resulted in a good recovery of VX2 rabbits.Compared with the control group,treated rabbits lived significantly longer(P\0.05),with 70%of treated animals surviving to 196 days posttreatment without metastasis or recurrence,while none of the controls did so.There was no local recurrence in the treatment group.All rabbits in the control group developed metastasis,while metastasis was only observed in 30% of treated rabbits.These results suggest that alternate cooling and heating ablation therapy can prolong the survival time of rabbits with VX2 liver tumors and is an effective method for tumor therapy.Furthermore,we also showed in this model that contrast enhanced US is a valid follow-up approach to assess treatment effectiveness.     

数字式胎儿心率计的设计与实现

提出一种对胎儿心动信号做实时处理的方法。利用快速傅氏变换在频域上直接从多普勒信号中求得胎儿心率、采用该方案的袖珍式胎儿监护仪具有较强的抗干扰能力,硬件简单、适应性强,应用结果表明本方法具有检测成功率高和运算快速的特点。     

成年女性年龄分层与颈总动脉结构重塑相关性研究

应用高频超声技术评估增龄对成年女性颈总动脉形态的影响。3886例成年女性每10岁为一个年龄层组,采用高频超声技术观察成年女性颈总动脉的管径及内-中膜的厚度。年龄分层分析显示女性自20岁起各年龄层的颈总动脉的管径和内-中膜的厚度伴随着年龄的增长而逐渐增加,50岁以后血管老化增速。年龄对女性颈总动脉内-中膜厚度的影响大于颈总动脉管径,血管管径因IMT增长而代偿性扩张的能力随着年龄的增加而呈现下降趋势,增龄可使成年女性颈总动脉发生衰老性结构重塑。     

Ultrasound effects on zinc recovery from EAF dust by sulfuric acid leaching

In this work, an ultrasound-assisted leaching process was studied for the recovery of zinc from electric arc furnace (EAF) dust, in which zinc was mainly present in the form of franklinite (60%). Hydrometallurgy is emerging as a preferred process for the recovery of a variety of metals, and the use of ultrasound could offer advantages over the conventional leaching process, especially for the dissolution of franklinite. Franklinite is a refractory phase that is difficult to leach and represents the main obstacle in conventional hydrometallurgy processing. Atmospheric leaching with different sulfuric acid concentrations (0.2-2.0 M) at two temperatures (323 and 353 K) was performed. The tests were conducted using both conventional and ultrasound-assisted leaching. After the leaching tests, the solid residues were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques, whereas the leach liquor was analyzed by inductively coupled plasma spectroscopy (ICP). The use of ultrasound facilitated the dissolution of franklinite at low acid concentrations and resulted in a greater zinc recovery under all of the investigated operating conditions.     

超声-Fenton氧化法处理啤酒废水的实验研究

论文采用超声与Fenton高级氧化技术联合处理啤酒废水,同时考察了影响啤酒废水COD去除率的影响因素.当功率为200 W,超声波频率为45 kHz,初始pH值为2,超声时间为20 min,H2O2浓度为70 mmol/L,FeSO4浓度为7 mmol/L时,啤酒废水COD去除率达到89.8%.     

肿瘤热疗超声无创监测技术研究进展

 肿瘤热疗是用加热方式杀死癌细胞,已成为肿瘤治疗的一种重要手段.肿瘤热疗分为传统热疗(41～45℃)和热消融治疗(>60℃).在肿瘤热疗中,对治疗区组织温度及热凝固区进行无创测控是保证热疗安全和提高疗效的关键,本文综述肿瘤热疗超声无创测温及热凝固区检测技术的研究进展.超声无创测温主要基于声速和热膨胀、超声衰减系数、背向散射能量、B 超图像纹理等参数的温度相关性.热凝固区超声检测主要基于超声组织定征技术,包括Nakagami 统计模型、超声衰减、超声背向散射积分、超声弹性成像、组织散射子平均间距、次谐波低频声发射等.提出了肿瘤热疗超声无创监测技术的未来发展方向,包括监测精度验证方法的研究、针对组织个体差异自适应调整参数的研究、减少组织运动干扰的方法研究、多维多参数监测方法研究、实时计算技术的研究及肿瘤热疗实验数据共享中心的建立.     

热疗的发展历程与展望

 热疗是一种历史悠久的疾病治疗方法,在中国和世界各地都有用热疗治愈疾病的历史记载.本文主要从技术、产品和临床3 个方面综合回顾了现代热疗的发展历程,分析了微波、射频、超声等热疗技术的进步和磁感应热疗等新型热疗技术的出现.分析表明,目前热疗已经发展到了一个新的高度,可以实现更高的治疗温度,温度控制更精确,副作用更小,疗效更好;在肿瘤治疗领域,热疗甚至有可能成为一种新的主流治疗手段,在一些常见的良性疾病治疗方面也将得到更广泛的应用.     

基于坦克对战系统的超声波定位技术改进

由于现有的射频-超声波定位技术应用到多坦克定位系统时会造成很大的延时误差,且定位过程复杂.为了提高超声波定位的实时性,将其改进为超声波定位技术,减少了射频装置从而也缩短了定位时间.整个改进设计以模型坦克对战系统作为基础,采用ALTERA公司的QuartusⅡ开发平台、MAXⅡ系列的CPLD技术以及VerilogHDL语言对系统完成建模与实现.通过仿真验证改进的超声波定位算法提高了系统的实时性,也使整体方案更简化.     

微纳米薄膜材料中激光皮秒超声的数值模拟

基于双温模型和热弹性耦合理论,采用有限元方法,针对A1/Si3N4和A1/Si3N4/Si两种层状薄膜材料中激励皮秒超声,建立激光飞秒超声的有限元数值模型,得到A1薄膜中电子和晶格的温度场,进而分析薄膜内部的应变和表面位移响应.对比研究了双温模型理论和傅里叶热传导理论的计算,结果表明皮秒超声研究采用双温模型求解温度场更为合适,数值分析得到应变具有幅值较小且波形展宽的结果.表面位移响应峰的形成是超声波在薄膜材料界面处发生反射引起的.     

杏鲍菇菌糠多糖对小鼠脾指数、脾淋巴细胞增殖及免疫因子的影响

目的 观察杏鲍菇菌糠多糖对小鼠脾指数、脾淋巴细胞增殖及免疫因子的影响。方法 将超声法提取制备的杏鲍菇菌糠多糖与基础饲料混合制成低剂量(200 mg/kg)、中剂量(400 mg/kg)及高剂量(800 mg/kg)三种多糖饲料。用48只KM小鼠,随机分为空白组,杏鲍菇菌糠多糖低、中、高剂量组。连续饲养60 d后,测定小鼠脾指数、脾淋巴细胞增殖和免疫因子IFN-γ、TNF-α及IL-6含量指标。结果 杏鲍菇菌糠多糖组与空白组相比,低剂量组显著提高脾指数(P<0.05),中剂量组能显著提高脾指数和脾淋巴细胞增殖(P<0.05),同时能提高免疫因子TNF-α、IL-6含量(P<0.05);高剂量组能显著提高小鼠的IFN-γ含量(P<0.05),极显著提高小鼠的脾指数、脾淋巴细胞增殖、TNF-α及IL-6含量(P<0.01)。结论 杏鲍菇菌糠多糖对小鼠的脾指数、脾淋巴细胞增殖及免疫因子具有调节作用。