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121.
向位置频繁变化的移动用户进行精准推荐,如何提高推荐准确性,已经成为一个理论研究与实践中的热点与难点问题.针对于此,本文提出了面向移动社交商务的精准用户兴趣点推荐模型--MRGR.首先,利用用户的历史签到信息,通过改进核密度估计对兴趣点进行预测;其次,进一步考虑到用户间的签到相似性,使用信息熵定量表示用户移动的随机性和不确定性;最后,融合地理位置信息与用户间相似性,精准推荐用户兴趣点,并在Foursquare数据集上进行验证.实验结果表明:与传统模型相比,提出的模型在准确预测用户兴趣点的同时,可以有效缓解数据稀疏性和冷启动问题,并在准确率和召回率上都取得了显著的提高.成果将为移动商务中,如何更好满足企业的精准推送与用户个性化需求提供有力的技术支持和决策服务. 相似文献
122.
定义了L-fuzzy拓扑空间中的相对T1分离性和相对正则(T3)分离性,讨论了相对T1分离性和相对正则(T3)分离性的一系列性质.证明了相对正则分离性和相对T3分离性是相对闭遗传的,弱同胚不变的,L-好的推广性质,给出了相对T3分离性不是相对遗传的一个反例. 相似文献
123.
社交网络用户影响力度量是意见领袖识别的必要前提,然而目前的度量模型忽略了多维影响因素以及水军群体对度量模型真实性的影响.为此本文从网络结构、交互行为和交互信息三个维度来分析整合相关的影响因素,基于LeaderRank模型构建多维用户影响力度量-MUI模型,并在水军识别的基础上构建信任惩罚模型,以修正MUI模型建立MUISTP模型,实现社交网络用户影响力的真实性度量.以新浪微博平台大规模实际数据进行实验分析结果表明,与FBI,LeaderRank和Generative Graphical模型相比,MUI模型识别出的意见领袖更为准确,且可以实现更为有效的信息扩散.此外,经过水军信任惩罚后MUISTP模型较MUI能够实现更为有效的意见领袖识别. 相似文献
124.
随着互联网海量信息的快速增长,由原来单一的以文本信息为主的信息处理发展成文本、语音、图像等多模态的信息处理.同时,用户的需求也从关键词搜索为主的信息获取向着基于语义理解的自动问答、辅助决策等智能交互的方向发展.本文从互联网服务信息处理特点以及用户需求变化出发,阐述了互联网信息处理面临的挑战和发展趋势.首先介绍了基于互联网的海量信息处理特点以及基本方法,然后分别阐述了互联网文本信息处理、语音信息处理、图像信息处理、位置信息处理的挑战以及发展趋势.最后介绍了如何对互联网的用户从属性、状态、兴趣3个维度进行建模,以满足用户个性化服务和商业分析的需要. 相似文献
125.
126.
针对倾斜转弯导弹,提出了最优/经典综合设计方法设计自动驾驶仪.该方法应用最优控制设计出俯仰/偏航混合通道三回路自动驾驶仪,设计中同时对开环系统的奇异值频域曲线进行约束,以保证系统具有一定的鲁棒性,获得的三回路自动驾驶仪结构简单,易于工程实现.仿真结果证实了其具有良好的跟踪性能和鲁棒性,也表明该自动驾驶仪能满足倾斜转弯导弹协调倾斜转弯的要求. 相似文献
127.
MurNAc etherases cleave the uniqued-lactyl ether bond of the bacterial cell wall sugar N-acetylmuramic acid (MurNAc). Members of this newly discovered family of enzymes are widely distributed among bacteria and
are required to utilize peptidoglycan fragments obtained either from the environment or from the endogenous cell wall (i.e.,
recycling). MurNAc etherases are strictly dependent on the substrate MurNAc possessing a free reducing end and a phosphoryl
group at C6. They carry a single conserved sugar phosphate isomerase/sugar phosphate- binding (SIS) domain to which MurNAc
6-phosphate is bound. Two subunits form an enzymatically active homodimer that structurally resembles the isomerase module
of the double-SIS domain protein GlmS, the glucosamine 6-phosphate synthase. Structural comparison provides insights into
the two-step lyase-type reaction mechanism of MurNAc etherases: β-elimination of the D-lactic acid substituent proceeds through
a 2,3-unsaturated sugar intermediate to which water is subsequently added.
Received 31 August 2007; received after revision 12 October 2007; accepted 1 November 2007 相似文献
128.
Starch-binding domains in the post-genome era 总被引:1,自引:1,他引:0
Starch belongs to the most abundant biopolymers on Earth. As a source of energy, starch is degraded by a large number of various
amylolytic enzymes. However, only about 10% of them are capable of binding and degrading raw starch. These enzymes usually
possess a distinct sequence-structural module, the so-called starchbinding domain (SBD). In general, all carbohydrate-binding
modules (CBMs) have been classified into the CBM families. In this sequence-based classification the individual types of SBDs
have been placed into seven CBM families: CBM20, CBM21, CBM25, CBM26, CBM34, CBM41 and CBM45. The family CBM20, known also
as a classical C-terminal SBD of microbial amylases, is the most thoroughly studied. The three-dimensional structures have
already been determined by X-ray crystallography or nuclear magnetic resonance for SBDs from five CBM families (20, 25, 26,
34 and 41), and the structure of the CBM21 has been modelled. Despite differences among the amino acid sequences, the fold
of a distorted β-barrel seems to be conserved together with a similar way of substrate binding (mainly stacking interactions
between aromatic residues and glucose rings). SBDs have recently been discovered in many non-amylolytic proteins. These may,
for example, have regulatory functions in starch metabolism in plants or glycogen metabolism in mammals. SBDs have also found
practical uses.
Received 25 May 2006; received after revision 26 June 2006; accepted 3 August 2006 相似文献
129.
Site- and state-specific lysine methylation of histones is catalyzed by a family of proteins that contain the evolutionarily
conserved SET domain and plays a fundamental role in epigenetic regulation of gene activation and silencing in all eukaryotes.
The recently determined three-dimensional structures of the SET domains from chromosomal proteins reveal that the core SET
domain structure contains a two-domain architecture, consisting of a conserved anti-parallel β-barrel and a structurally variable
insert that surround a unusual knot-like structure that comprises the enzyme active site. These structures of the SET domains,
either in the free state or when bound to cofactor S-adenosyl-L-homocysteine and/or histone peptide, mimicking an enzyme/cofactor/substrate complex, further yield the structural insights
into the molecular basis of the substrate specificity, methylation multiplicity and the catalytic mechanism of histone lysine
methylation.
Received 10 June 2006; accepted 22 August 2006 相似文献
130.
Kertész A Váradi G Tóth GK Fajka-Boja R Monostori E Sármay G 《Cellular and molecular life sciences : CMLS》2006,63(22):2682-2693
Phosphopeptides interacting with src homology 2 (SH2) domains can activate essential signaling enzymes in vitro. When delivered to cells, they may disrupt protein-protein interactions, thereby influencing intracellular signaling. We
showed earlier that phosphopeptides corresponding to the inhibitory motif of Fcγ receptor IIb and a motif of the Grb2-associated
binder 1 adaptor protein activate SH2-containing tyrosine phosphatase 2 in vitro. To study the ex vivo effects of these peptides, we have now compared different methods for peptide delivery: (i) permeabilization of the target
cells and (ii) the use of cell-permeable vectors, which are potentially able to transport biologically active compounds into
B cells. We found octanoyl-Arg8 to be an optimal carrier for the delivery of phosphopeptides to the cells. With this strategy, the function of cell-permeable
SHP-2-binding phosphopeptides was analyzed. These peptides modulated the protein phosphorylation in B cells in a dose- and
time-dependent manner.
Received 27 July 2006; received after revision 4 September 2006; accepted 18 September 2006 相似文献