Determination of risperidone in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study in Chinese volunteers

This study presents a rapid, specific and sensitive liquid chromatography/tandem mass spectrometry （LC-MS/MS） assay for determination of risperidone （RIS） in human serum using paroxetine as an internal standard （IS）. An Alltima-C18 column （2.1 mm×100 mm, 3 μm） and a mobile phase consisting of 0.1% formic acid-acetonitrile （40：60, v/v） were used for separation. The analysis was performed by selected reaction monitoring （SRM） method, and the peak area of the m/z 411.3→191.1 transition for RIS was measured versus that of the m/z 330.1→192.1 transition for IS to generate the standard curves. The assay linearity of RIS was confirmed over the range 0.25-50.00 ng/ml and the limit of quantitation was 0.05 ng/ml. The linear range corresponds well with the serum concentrations of the analytes obtained in clinical pharmacokinetic studies. Intraday and interday relative standard deviations were 1.85%-9.09% and 1.56%-4.38%, respectively. The recovery of RIS from serum was in the range of 70.20%-84.50%. The method was successfully applied to investigate the bioequivalence between two kinds of tablets （test versus reference products） in 18 healthy male Chinese volunteers. The result suggests that two formulations are bioequivalent.     

关于粤方言词“靓”的历史考察与使用误区透视

“靓”本是一个古语词和方言词,曾一度消失于汉语普通话中。随着粤语的北上,“靓”由粤方言进入共同语中泛化使用。近十余年来,“靓”的使用在全国尤其是在粤港地区人们日常生活口语中呈现一种滥用的状态,其词义的感情色彩在逐渐发生转移。     

利用图像分析法研究不同浆料配比对打印质量的影响

利用图像分析方法研究浆料配比和填料的种类对喷墨打印纸的打印质量的影响.根据油墨的渗透和扩散行为而导致的点的边缘锐化值、文字的羽化程度和点的喷墨打印质量指数等研究喷墨打印质量.研究结果表明：加填是影响喷墨打印纸打印质量的最重要因素.浆料配比对于以打印点的边缘锐化值、纸页的打印文字面积和点的喷墨打印质量指数表示的打印质量没有明显影响,但对于不加填和研磨碳酸钙加填的纸页,纸页打印点的边缘锐化值随着针叶木浆料占混合浆料的比值的增大而增加,这表明对于不加填纸,阔叶木浆有利于提高以点的边缘锐化值表示的打印效果.     

The Grid Algorithm of the Development Coefficient and the Combination Coefficient of Background Value in GM（1,1） Model

This article gives the algorithm of the sector in which the development coefficient is, and the steps to simultaneously calculate the development coefficient and combination coefficient of background value. Unifying the development coefficient and the background value＇s coefficient of combination to optimize the model together, avoiding the malpractice to separate the two in traditional method, and avoiding the error brought out by matrix multiplication because of matrix＇s illness and so on in the traditional way, therefore increases the precision of the model.     

Fundamental geological elements for the occurrence of Chinese marine oil and gas accumulations

The Paleozoic strata in the Tarim Basin, Sichuan Basin and Ordos Basin are the major targets for marine petroleum exploration, with developed high quality hydrocarbon, mainly argillite. The deep burial of these source rocks suggests that they mainly develop gas instead of oil. But different maturities of organic matter may lead to different hydrocarbon facies. Through thermochemical sulfate reduction （TSR）, the hydrocarbon in the carbonate rocks may undergo a process of pyrolytic cracking and be catalyzed into gases. The marine reservoirs mainly consist of carbonate and clastic rocks, and the former is controlled by sedimentary facies, dolomitization, solution, TSR and cracking. The multiphase tectonic cycling develops multiple source-reservoir-cap combinations and diversified types of traps and reservoirs, featuring multiphase reservoir formation, mainly late-phase formation or consolidation. Palaeo-uplifts play a controlling role in hydrocarbon accumulation. Differences in major source rocks in the three basins lead to different locations of oil-gas accumulation layers, different types and patterns of reservoirs and different features of reservoir formation.     

以丙烯酸-β-羟乙酯与丙烯酸为原料制备二丙烯酸乙二醇酯

以丙烯酸（AA）与丙烯酸-β-羟基乙酯（HEA）为原料，经酯化反应合成出了二丙烯酸乙二醇酯（EGDA）。以EGDA得率为考核指标，对催化剂种类及用量、阻聚剂种类及用量等合成条件进行了实验研究与优化，发现对于该反应，环己烷是比苯更优的带水剂，反应宜采用减压降温的方法抑制聚合的发生。对比分析表明，采用该方法制备EGDA的得率比直接酯化法、酯交换法更高，且产品的品质更好。     

碳酸盐岩发育土壤中的磁赤铁矿及其成因机理研究

设计了土壤氧化铁矿物提取方法和分析流程，成功地从碳酸盐岩发育土壤中提取到较纯的磁赤铁矿微结核，运用多种矿物学方法进行了较系统的矿物学研究，并探讨了其成因机理。     

加纳共和国体育场建筑设计

本文主要介绍加纳共和国Ghana体育场建筑设计情况。     

碳酸钙矿石晶粒尺寸对其受热后状态的影响

为研究不同晶粒的碳酸钙矿石用于造渣的优劣性,对6种晶粒不同的碳酸钙矿石进行了X射线衍射、压汞、扫描电镜分析等试验,研究了它们的晶粒尺寸、碎裂程度、碎裂过程和煅烧后的比孔容、体积密度、孔隙率、平均孔径、活性度等因素,分析了矿石晶粒尺寸对其热裂性和煅烧所得石灰的微观结构参数、活性的影响。结果表明,矿石晶粒度越大,煅烧所得石灰越疏松多孔,活性越高,在急速受热时会发生爆裂,化渣速度更快。     

利用示踪剂资料讨论塔河缝洞性油藏井间连通方式

探讨塔河油田缝洞型碳酸盐岩油藏多缝洞系统的井间连通方式。针对缝洞型碳酸盐岩油藏井间储集层复杂的特点,通过示踪剂曲线特征分析油藏井间连通方式,从峰型、主峰高宽比、主峰拟面积和注水推进速度4个方面评价曲线特征与连通方式之间的关系,结果表明塔河油田主要有单一连通型和复合连通型2种连通方式,其中以单一连通型为主,占73.5%。典型井分析说明连通方式与单井所处的地质条件有关。