基于工件网格划分的周铣加工表面形貌仿真算法

运用图形矩阵变换原理和矢量运算法则，推导出了立铣刀周铣过程中刀具切削丸上任意点相对于工件运动的轨迹方程，在此基础上构造出一种基于工件网格划分的三维表面形貌仿真算法，并给出了相应的仿真算例，仿真结果表明，该算法可完全模拟铣削过程，具有运算速度快，仿真精度高和便于出图等优点。     

基于网络药理学的金荞麦治疗糖尿病肺病的作用机制

基于网络药理学研究金荞麦治疗糖尿病肺病的主要化学成分,作用靶点和相关信号通路.利用TCMSP数据库检索金荞麦主要的活性成分及作用靶点;基于OMIM和Gene Cards数据库找出与糖尿病肺病相关的作用靶点,求金荞麦主要成分的作用靶点与糖尿病肺病的相关靶点交集,将交集靶点导入STRING数据库构建PPI网络,对该网络进行拓扑分析找出关键靶点;把关键靶点导入DAVID 6.8.0数据库,找出金荞麦治疗糖尿病肺病关键靶点参与的生物学过程、分子功能、细胞组分和KEGG通路.结果显示,通过TCMSP数据库的口服利用度(OB)和类药性(DL)条件筛选出15个金荞麦主要化合物,相应作用靶点85个;与糖尿病肺病发病机制有关的作用靶点18个,经PPI网络分析得到9个关键靶点;GO分析富集得到生物过程72个,分子功能14个,细胞组分8个,65条KEGG信号通路.表明金荞麦治疗糖尿病肺病发挥药效的有效成分可能是没食子酸酯、(+)-儿茶素、β-谷甾醇、异鼠李素和原花青素B1等化合物,作用机制可能跟MAPK1、AKT1、EGFR、EGF、JUN等靶点,以及Erb B信号通路、Ras信号通路、癌症中的胆碱代谢、MAPK信号通路、局灶性粘连及TNF信号通路有关.     

防止高拱坝坝踵开裂和屈服的工程措施研究

对防止高拱坝坝踵开裂和屈服的两种常用工程措施周边缝和底缝进行研究．研究中坝体混凝土、缝和坝基材料采用不同的非线性材料模型．结合292m高的小湾拱坝对设缝前后的坝体位移场、应力场、开裂区和屈服区进行分析研究,重点讨论设缝对坝体屈服和开裂的影响．对小湾拱坝的研究结果表明：(a)未设缝时,在坝基附近的垫座内出现较大范围的开裂和屈服;设置周边缝时,垫座内的开裂和屈服明显减少;设置底缝时,坝踵附近的开裂和屈服明显减少,但在设缝两侧,尤其是两侧缝端附近,垫座内的屈服现象比无缝情况时更严重．(b)小湾拱坝设周边缝的效果要优于设底缝,设缝范围可限制在缝面开裂的范围内．     

计算机及其外部设备的防信息泄漏技术

计算机中的电磁泄漏严重威胁系统的安全,必须采取有效的防泄漏措施.介绍了计算机中信息的泄漏方式,分析了TEMPEST技术研究的内容,探讨了利用噪声干扰源,采用屏蔽技术、"红"/"黑"隔离技术、滤波技术和布线与元器件选择等计算机防泄漏技术,以及键盘、软盘驱动器、CRT显示器和打印机等外部设备的防泄漏技术,探讨了发展我国TEMPEST技术的5项措施.     

Bromocriptine/SKF38393 ameliorates islet dysfunction in the diabetic (db/db) mouse

Dysfunction of pancreatic islets plays a crucial role in the etiology of type II diabetes. Chronic hyperglycaemia or hyperlipidaemia may impair islet function. Previous studies by our laboratory have demonstrated that dopaminergic agonists ameliorated hyperglycaemia and hyperlipidaemia in obese and diabetic rodents. In the present study, we investigated the effect of a treatment with the dopamine D₂ /D₁ receptor agonists (bromocriptine/SKF38393, BC/SKF) on islet dysfunction in db/db mice. Our results show that a 2-week BC/SKF treatment markedly reduced hyperglycaemia and hyperlipidaemia, and significantly improved islet dysfunction demonstrated by an increase of secretagogue-stimulated insulin release from islets of db/db mice to levels observed in islets from lean mice. There was also a fourfold increase of insulin content in the pancreas of BC/SKF-treated db/db mice compared with that in untreated controls. The effect of BC/SKF on islet function cannot be mimicked in pair-fed animals. BC/SKF had no direct stimulatory effect on islet insulin secretion, suggesting BC/SKF treatment improved islet function via an indirect mechanism. This treatment markedly improved the abnormally elevated daily levels of corticosterone, blood glucose and plasma lipids, supporting the view that BC/SKF may affect the neuroendocrine system that in turn regulates peripheral metabolism and thereby improves islet function. Received 3 April 1998; accepted 27 April 1998     

Haptoglobin development in newborn infants from diabetic mothers

Haptoglobin (Hp) development during the neonatal period has been studied in 325 newborn infants from normal pregnancies and in 242 infants from diabetic mothers. In infants from diabetic mothers Hp development is delayed as compared to infants from normal pregnancies. This delay is associated with a change in the pattern of relationship between Hp development and the polymorphism of acid phosphatase (ACP1) (an enzyme which shows phosphotyrosine phosphatase (PTPase) activity). In infants from normal pregnancies who show ACP1 phenotypes with the highest activity, the appearance of Hp is accelerated as compared to other infants. In contrast, infants from diabetic pregnancies who have ACP1 phenotypes with the highest activity, show delayed Hp development.     

Combined-dynamic mode “dip-pen” nanolithography and physically nanopatterning along single DNA molecules

Atomic force micriscope (AFM)-based dip-pen nanolithography (DPN) is an emerging approach for constructing nanostructures on material surfaces such as gold, silicon and silicon oxide. Although DPN is a powerful technique, it has not shown its ability of direct-writing and patterning of nanostructures on surfaces of soft materials, for example biomacromolecules. Direct depositing on soft surfaces becomes possible with the introduction of a combined-dynamic mode DPN rather than mostly used contact mode DPN or tapping mode DPN. In this report, the combined dynamic mode DPN is used for direct depositing protein ink on DNA molecules at the nanometer scale.     

Silurian to Devonian foreland basin in the south edge of Tarim Basin

Based on the theory of plate tectonics, combin-ing with the isotopic dating of ophiolite, igneous and volcan-ics, geochemical test, rare earth element analyze and seismicinterpretation, this paper studies the pre-Carboniferous tec-tonics and sedimentary formation of the south edge of theTarim Basin and proves that there exists the Kunlun Oceanunder tensional tectonics during the Sinian and Cambrian inthe south edge of the Tarim Plate. After that, due to the colli-sion orogenesis, there formed the peripheral foreland basinin the south edge of Tarim. The Upper Silurian and Devo-nian molasses sedimentary system superposed on the Sinianand Middle Silurian passive margin flysch sedimentary sys-tem and formed the bivariate structure of the foreland basin.And at the same time, based on the field geology and seismicinterpretation, we have identified that the formation of theSilurian and Devonian have the character of half depositwhich shows thick in the south area and thin in the north,and the pre-Carboniferous thrust compression tectonics re-mained in the foreland thrust belt, which further demon-strates that there existed the Silurian and Devonian periph-eral foreland basin on the south edge of the Tarim Basin.     

Protein P37 of mycoplasma hyorhinis induces secretion of TNF-α from human peripheral blood mononuclear cells

High mycoplasmal infection ratio in gastric cancer tissues suggests a possible association between my-coplasma infection and tumorigenesis.Because TNF-α plays an important role in carcinogenesis caused by microbes in-fection and P37 is a major immunogen of mycoplasma hy-orhinis(M.hyor.),investigating whether P37 could induce expression and secretion of TNF-α will be very significant fo elucidate the possible molecular mechanism of gastric car-cinogenesis involved with M.hyor.At the present study,we cloned full gene of p37 by PCR and mutated the 7 codes of TGA into TGG firstly,then expressed the P37 protein suc-cessfully with pGEX-4T-1 vector in E.coli,which was veri-fied with Western bolt.By RT-PCR and sensitive L929 cell toxic assay,we found that P37 protein could induce expres-sion and secretion of TNF-α from human peripheral blood mononuclear cells,and the inducing activity of P37 could be dramatically blocked by McAb PD4.These results suggest that the induction of TNF-α secretion by P37 probably plays an importan role in diseases caused by M.hyor.infection and needs to be further investigated.     

Dog sciatic nerve gap repaired by artificial tissue nerve graft

The feasibility of repairing dog sciatic nerve damage by using a biodegradable artificial tissue nerve graft enriched with neuroregenerating factors is investigated. The artificial nerve graft was implanted to a 30 mm gap of the sciatic nerve damage in 7 dogs. The dogs with the same nerve damage that were repaired by interposition of the autologous nerve or were given no treatment served as control group 1 or 2, respectively. The observations include gross and morphological observations, immune reaction, electrophysiological examination, fluorescence tracing of the neuron formation and the number of the neurons at the experimental sites, etc. Results showed that 6 months after the implantation of the graft, the regenerated nerve repaired the damage of the sciatic nerve without occurrence of rejection and obvious inflammatory reaction in all 7 dogs, and the function of the sciatic nerve recovered with the nerve conduction velocity of (23.91±11.35)m/s. The regenerated neurons and the forming of axon could be observed under an electron microscope. This proves that artificial tissue nerve graft transplantation can bridge the damaged nerve ends and promote the nerve regeneration.