Phytanic acid impairs mitochondrial respiration through protonophoric action

Refsum disease is a rare, inherited neurodegenerative disorder characterized by accumulation of the dietary branched-chain fatty acid phytanic acid in plasma and tissues caused by a defect in the alphaoxidation pathway. The accumulation of phytanic acid is believed to be the main pathophysiological cause of the disease. However, the exact mechanism(s) by which phytanic acid exerts its toxicity have not been resolved. In this study, the effect of phytanic acid on mitochondrial respiration was investigated. The results show that in digitonin-permeabilized fibroblasts, phytanic acid decreases ATP synthesis, whereas substrate oxidation per se is not affected. Importantly, studies in intact fibroblasts revealed that phytanic acid decreases both the mitochondrial membrane potential and NAD(P)H autofluorescence. Taken together, the results described here show that unesterified phytanic acid exerts its toxic effect mainly through its protonophoric action, at least in human skin fibroblasts. Received 4 August 2007; received after revision 26 September 2007; accepted 10 October 2007 J. C. Komen, F. Distelmaier: These authors contributed equally to this work.     

次线性期望下具有随机系数相依线性过程的完全积分收敛性

利用不同于概率空间的研究方法,给出当CVεp<∞时次线性期望下具有随机系数的相依线性过程的完全积分收敛性,从而将概率空间下具有随机系数的相依线性过程的完全矩收敛推广到次线性空间中.     

Fuzzy Economic Order Quantity Inventory Models Without Backordering

In economic order quantity models without backordering, both the stock cost of each unit quantity and the order cost of each cycle are characterized as independent fuzzy variables rather than fuzzy numbers as in previous studies. Based on an expected value criterion or a credibility criterion, a fuzzy expected value model and a fuzzy dependent chance programming (DCP) model are constructed. The purpose of the fuzzy expected value model is to find the optimal order quantity such that the fuzzy expected value of the total cost is minimal. The fuzzy DCP model is used to find the optimal order quantity for maximizing the credibility of an event such that the total cost in the planning periods does not exceed a certain budget level. Fuzzy simulations are designed to calculate the expected value of the fuzzy objective function and the credibility of each fuzzy event. A particle swarm optimization (PSO) algorithm based on a fuzzy simulation is designed, by integrating the fuzzy simulation and the PSO algorithm. Finally, a numerical example is given to illustrate the feasibility and validity of the proposed algorithm.     

平稳高斯序列的联合渐近分布

{Xn}为标准的平稳高斯序列,在弱相依条件下,文章得到了此序列的第k个最大值Mn(k)与其出现的位置Ln(k)的联合渐近分布,以及此序列的前k个最大值的联合渐近分布。     

基于势场导向的对数蚁群算法的移动机器人路径规划

针对蚁群算法存在收敛速度慢,易陷入局部最优的问题,提出了一种将人工势场和对数蚁群算法相融合的新算法.该算法是在蚁群算法的基础上,将势场的影响因素引入到蚁群算法的状态转移概率函数和启发函数中,并通过对数函数模型对蚁群算法的信息素更新策略进行改进,使得路径算法搜索不再具有盲目性,并加快算法的收敛速度.为了验证改进算法的有效...     

地铁干扰下管道极化电位测试方法及应用

地铁干扰下管道阴极保护电位呈现频繁波动的特点,无法通过传统的断电法获得管道的真实保护电位。从需要断开所有外部电源的角度出发,提出采用试片断电法进行干扰下管道极化电位的测试,并通过现场试验研究,确定了影响管道极化电位准确测试的主要因素及其影响规律,建立了地铁干扰下管道极化电位有效测试的参数设置方法:试片极化达到稳定的时间不少于2.25 h;试片的埋设深度不低于0.30 m;试片与参比的水平间距宜为0.05～0.10 m。     

水合镁离子的分子动力学模拟研究

基于水合离子[M(H2O)m]n+的概念,利用Moldy分子动力学模拟并结合分子内相互作用势MCY来研究水中的镁离子.该模拟系统包括一个二价的镁离子和216个水分子,在温度为330K下,计算了系统内不同原子对之间的径向分布函数(RDF),模拟结果和实验值基本一致.而且从其径向分布函数可看出,镁离子的出现并没有使得镁离子周围的第一水化层水分子和第二水化层水分子之间的距离有明显的减少.     

He-N2碰撞体系相互作用势及微分散射截面的研究

作者运用量子化学从头计算方法,在MP2/6-311++G(3df,2p)水平下,计算了He-N2相互作用的势能表面,构造了He原子与N2分子相互作用的各向异性势函数,用密耦方法计算了He原子与N2分子碰撞的微分散射截面,计算结果与实验数据符合较好.     

O2-O2,O2-N2和O-N2分子相互作用势模型

利用Tang Toennies(TT)势模型,计算了O2-O2,O2-N2,和O-N2相互作用势,得到了重要的的相互作用势的参数Rm和ε,并在此基础上计算了O2-O2系统的输运系数.其结果与文献值符合较好,说明TT势模型对于计算氧分子系统是可行的.     

电凝聚控制MBR膜污染的研究

试验考察了SECMBR的膜过滤特性,探讨了电凝聚对控制MBR膜污染的作用及机理.试验结果表明:胞外聚合物(EPS)、溶解性代谢产物(SMP)、ζ电位和污泥颗粒粒径等是膜污染的重要影响因素.SECM BR的膜污染远小于SM BR;SECM BR原位溶出铁离子与EPS结合,絮凝性增强,滤饼层污染减轻;SECM BR中电凝聚可降低单位容积活性污泥分泌的SM P与EPS,减轻膜污染;SECM BR降低EPS和SM P中主要污染物蛋白质的比例,减轻膜污染;ζ电位与Rc之间呈负相关,在SMBR与SECMBR中相关度分别为-0.798 8和-0.557 4.SECM BR在电场与铁粒子作用下降低了ζ电位绝对值,减轻了膜污染.