预测支持系统中的人机界面Agent及其机器学习

人机界面 agent是一种具有一定智能性 ,并能增强应用系统与用户间交互的计算机程序 .通过机器学习机制 ,这种 agent能够适应用户的习惯 ,使系统更有效的服务于用户 .本文将界面 agent( Interface agent)技术应用于预测支持系统 ( FSS:Forecasting Support System)中 ,并采用适当的学习方法 ,可以很好地解决其中的复杂人机交互问题     

Selectivity determinants of the aldose and aldehyde reductase inhibitor-binding sites

Aldose reductase and aldehyde reductase belong to the aldo-keto reductase superfamily of enzymes whose members are responsible for a wide variety of biological functions. Aldose reductase has been identified as the first enzyme involved in the polyol pathway of glucose metabolism which converts glucose into sorbitol. Glucose over-utilization through the polyol pathway has been linked to tissue-based pathologies associated with diabetes complications, which make the development of a potent aldose reductase inhibitor an obvious and attractive strategy to prevent or delay the onset and progression of the complications. Structural studies of aldose reductase and the homologous aldehyde reductase in complex with inhibitor were carried out to explain the difference in the potency of enzyme inhibition. The aim of this review is to provide a comprehensive summary of previous studies to aid the development of aldose reductase inhibitors that may have less toxicity problems than the currently available ones. Received 4 December 2006; received after revision 12 February 2007; accepted 20 April 2007     

Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism

The metabolism of all-trans- and 9-cis-retinol/ retinaldehyde has been investigated with focus on the activities of human, mouse and rat alcohol dehydrogenase 2 (ADH2), an intriguing enzyme with apparently different functions in human and rodents. Kinetic constants were determined with an HPLC method and a structural approach was implemented by in silico substrate dockings. For human ADH2, the determined K_m values ranged from 0.05 to 0.3 μM and k_cat values from 2.3 to 17.6 min⁻¹, while the catalytic efficiency for 9-cis-retinol showed the highest value for any substrate. In contrast, poor activities were detected for the rodent enzymes. A mouse ADH2 mutant (ADH2Pro47His) was studied that resembles the human ADH2 setup. This mutation increased the retinoid activity up to 100-fold. The K_m values of human ADH2 are the lowest among all known human retinol dehydrogenases, which clearly support a role in hepatic retinol oxidation at physiological concentrations. Received 12 October 2006; received after revision 6 December 2006; accepted 8 January 2007     

基于平台的SoC设计技术研究

文章分析了平台的概念及基于平台的SoC的设计流程,重点讨论了平台的构建方法及基于平台的产品开发过程中的2个关键问题,即IP(Intellectual Property)集成方法和参数化总线桥的设计,为构建平台库及顺利利用平台进行SoC产品开发积累了一定的经验。     

人机工程学在厨房小工具设计中的应用

人机工程学是产品设计重要方法之一,通过阐述人机因素的重要意义,分析其在厨房小工具设计中的具体应用,就人机工程学包含的三个要素:环境、人、机以及三者关系进行了详细分析.     

曲线符号在产品设计中的运用

曲线在产品设计中是一种普遍使用的设计元素符号,通过阐述曲线的数学和美学意义及其在产品设计中的运用方法,并从“工艺美术运动”到后现代设计这个历史过程,完整地阐述了不同时期曲线符号在产品设计中的运用.     

多元化发展的新现代主义建筑——以美国为例

20世纪80年代后,新现代主义建筑的实践越来越趋向于多元化,不仅保留了新现代主义理性的特点,同时也积极与各种设计理念融合,在建筑理论多元化的今天迸发出新的生命力.通过对美国建筑实践的分析,了解现代建筑界一些新的发展趋势,将有助于我们今后的建筑创作.     

电子信息专业学生计算机能力培养体系构建研究

从当前电子信息专业学生能力、素质方面的不足,指出当前采用的电子信息专业的课程体系中对计算机能力培养的偏失,结合计算机与电子信息发展的融合趋势和电子信息专业计算机能力培养的特点,归结电子信息专业学生计算机能力培养的4个层次,从而逐步建立较为完善的体系结构.     

计算机专业实验教学模式的思考与探索

针对计算机专业实验教学在教学内容、教学模式、教学计划等方面存在的问题,借鉴国内外部分高校成功的实验教学经验,提出计算机专业实验教学开放式的改革思路,并付之教学实践,取得了较好的教学效果.     

基于情感分析的汽车造型设计感性评价方法

针对分析用户感性评价时出现的数据采集范围不够广、成本高、数据准确性低、非结构化数据利用率低等问题,提出一种基于情感分析的工业设计感性评价方法,以纯电动汽车为例,构建电动汽车造型感性意象的预测模型。首先基于情感分析量化用户的主观评论,获得感性意象评分,然后针对纯电动汽车的造型特征,提取了与传统内燃机汽车存在差异的主要设计要素,最后通过数量化理论I建立感性意象评分与设计要素的映射模型。以电动汽车设计方案优化为例,证明了该方法的可行性,预测结果的相对误差为5.41%。该方法符合用户的主观认知,能够有效预测用户对方案的感性评价,从而辅助设计师根据感性评价优化产品设计,具有实际应用价值。