Hsp70 chaperones: Cellular functions and molecular mechanism

Hsp70 proteins are central components of the cellular network of molecular chaperones and folding catalysts. They assist a large variety of protein folding processes in the cell by transient association of their substrate binding domain with short hydrophobic peptide segments within their substrate proteins. The substrate binding and release cycle is driven by the switching of Hsp70 between the low-affinity ATP bound state and the high-affinity ADP bound state. Thus, ATP binding and hydrolysis are essential in vitro and in vivo for the chaperone activity of Hsp70 proteins. This ATPase cycle is controlled by co-chaperones of the family of J-domain proteins, which target Hsp70s to their substrates, and by nucleotide exchange factors, which determine the lifetime of the Hsp70-substrate complex. Additional co-chaperones fine-tune this chaperone cycle. For specific tasks the Hsp70 cycle is coupled to the action of other chaperones, such as Hsp90 and Hsp100.Received 21 October 2004; received after revision 24 November 2004; accepted 6 December 2004     

森林凋落物与土壤质量的互作效应研究

凋落物与土壤的相互关系研究是生态学领域的研究热点之一,其中凋落物质量对土壤质量的影响较大。本文阐述了凋落物质量对土壤质量的影响,从土壤生物学性质、理化性质等方面概述了土壤质量对凋落物分解所起的作用,并就凋落物和土壤的相互关系进行了评述,展望了该研究领域的发展趋势。     

数控机床边界强度过程的非等周期不完全预防维修

基于边界强度过程理论,提出了数控机床在可靠度限制下任意维修质量的非等周期不完全预防维修方法,建立了综合考虑维修对役龄的影响和故障强度随时间增加的混合模型,并且假设修复质量和故障强度增加值均为服从均匀分布的随机变量,以平均维修费用为目标函数,用迭代方法给出了非等周期预防维修周期和最佳的维修次数,并结合工程实例讨论了费用参数对平均维修费用的影响.     

面向实时业务的快速公平性分组调度算法

长期演进系统(long term evolution,LTE)中的分组调度算法需要满足一定的QoS.针对最大权值时廷优先算法(modified large weighted delay first,M-LWDF)在用户公平性方面的缺陷,提出了基于线性优先级和非线性优先级的M-LWDF算法,以达到提升用户公平性的目的.仿真结果表明,所提出的算法能够在牺牲少量系统吞吐量的情况下,较大程度地改善用户公平性和业务的丢包率.     

玉米粉质胚乳突变体的研究进展

玉米是世界上重要的粮食作物,也是植物分子遗传研究的重要模式。通过对玉米的长期研究积累了大量的遗传突变体,其中有一类籽粒突变体被称为粉质（opaque 或floury）胚乳突变体,表现为籽粒硬度和透明度下降。同时,这类突变体中的opaque2 等,被发现能够显著改善玉米籽粒的蛋白营养水平,使得粉质胚乳突变体受到了很大的关注。早年只有少数的粉质胚乳突变体基因被克隆和研究,如opaque2 和floury2 等,被发现与玉米主要的储藏蛋白转录和合成有关。近年来,随着科学技术和研究能力的提高,更多的opaque突变体基因,如opaque1、opaque5、opaque7 等,被克隆和研究,为我们揭示了玉米籽粒中储藏物质的合成、转运等更深入的调控机制,拓展了我们对玉米胚乳发育和代谢的知识。     

高校考试质量控制与试卷档案规范管理

随着经济社会的快速发展,人力资源市场对高素质人才的需求标准也越来越高。高等教育如何实现高素质人才目标的培养,使得高校毕业生在走向职场时能尽快展现职业岗位的胜任力、缩短人职匹配的磨合期,同样有了新的要求。高校提高人才培养质量的重要途径之一,就是加强考试质量的控制、规范试卷档案的管理。对于考试质量的控制主要体现在考试试题的质量、考试过程的监控以及考试试卷的评分和反馈信息的分析等方面;对于考试试卷档案的规范管理,已引起人们的高度关注,做到试卷档案的规范管理、更好地为教育教学改革服务,是人们针对试卷档案管理工作进行研究的新方向。     

高校图书馆大规模馆藏精准迁移模式探讨--以华北电力大学图书馆为例

书库藏书迁移的运作主要在于精心准备和周密筹划。详细介绍了华北电力大学图书馆利用汇文文献信息服务系统的强大分析功能并结合Excel软件的使用技巧,实现大规模馆藏迁移精准排架工作的经验。     

从我院学生拖欠学费情况谈收费管理

近年学生拖欠学费呈增长态势,直接影响到学院的教学、科研活动和事业发展.分析了我院学生拖欠学费的现状、影响及其主要原因,并提出相应的对策.     

Theoretical construction in physics – The role of Leibniz for Weyl's ‘Philosophie der Mathematik und Naturwissenschaft’

This paper aims at closing a gap in recent Weyl research by investigating the role played by Leibniz for the development and consolidation of Weyl's notion of theoretical (symbolic) construction. For Weyl, just as for Leibniz, mathematics was not simply an accompanying tool when doing physics—for him it meant the ability to engage in well-guided speculations about a general framework of reality and experience. The paper first introduces some of the background of Weyl's notion of theoretical construction and then discusses particular Leibnizian inheritances in Weyl's ‘Philosophie der Mathematik und Naturwissenschaft’, such as the general appreciation of the principles of sufficient reason and of continuity. Afterwards the paper focuses on three themes: first, Leibniz's primary quality phenomenalism, which according to Weyl marked the decisive step in realizing that physical qualities are never apprehended directly; second, the conceptual relation between continuity and freedom; and third, Leibniz's notion of ‘expression’, which allows for a certain type of (surrogative) reasoning by structural analogy and which gave rise to Weyl's optimism regarding the scope of theoretical construction.     

Rediscovery of Disepyris semiruber (Kieffer) (Hymenoptera: Bethylidae) in Southern Africa,with first description of the male

Holepyris semiruber Kieffer is redescribed and illustrated based on freshly collected specimens. Holepyris semiruber var. striatipleura Kieffer is considered a colour variant of this species and therefore a junior synonym of H. semiruber syn. nov. This species is transferred to Disepyris, D. semiruber (Kieffer) comb. nov., based on the possession of a short 2r-rs&Rs vein in the fore wing and presence of long flat spine-shaped setae on the outer (posterior) surface of the protarsi. The male is described for the first time from new specimens collected in South Africa. This species is recorded for the first time from Namibia and Zimbabwe. All photographs are available on www.waspweb.org.