值得研究的教育思想

本简略地介绍了弗赖登塔尔的数学教育思想与荷兰的教育状况,概述了对该数学教育思想进行研究的价值和意义。     

第(3)类φ-压缩映射对的一个新的公共不动点定理

证明了第 ( 3)类 φ 压缩映射对的一个新的公共不动点定理 ,推广文献 [1～ 3]中的相关结果     

分布式计算方法的研究

针对Client/Server体系结构的不足,分析研究了分布式体系结构,提出了基于分布式体系结构的应用解决方案。     

人体下颌骨前伸后的骨应力研究

通过CT技术获取人体下颌各层面的解剖轮廓图,经三维重建从生物力学角度分析下颌前伸后下颌不同部位的应力情况.选择一处于生长发育高峰期的典型Ⅱ类患儿,采用CT技术对整个下颌骨进行断层扫描,将其输入计算机给定前伸条件咬合重建,在CAD软件中建立几何模型,将其导入MSC.PATRAN建立有限元模型.结果显示髁突后缘及下颌体磨牙区出现拉应力集中区,下颌骨下缘及下颌角区为压应力集中区.本实验对下颌前伸后下颌内部的应力情况进行了客观分析,从理论上推断并支持了功能矫治后下颌骨的生长改型变化.     

基于多元共生遗传神经网络的藻类预测仿真

提出一种多元共生遗传神经网络(PGANN),从遗传算法和神经网络——进化和学习两方面及其相互关系着手完善进化过程,以提高优化效果和泛化能力。该算法包括一个共生平衡交叉算子,一种多元选择策略和一种神经网络的分级优化策略,其中共生平衡算子能够兼顾进化过程中的方向性、多样性和自适应性;多元选择策略能够适应进化过程不同时段对选择压力不同的需求;而分级优化使运算规模和运算速度之间的矛盾得到缓解。将该改进的遗传神经网络PGANN应用于水库和湖泊有毒的优势蓝绿藻爆发预测,取得了满意的效果。     

The cold case: Are rhinoviruses perfectly adapted pathogens?

Rhinoviruses, which cause common cold, belong to the Picornaviridae family, small non-enveloped viruses (diameter 15-30 nm) containing a single-stranded RNA genome (about 7 kb). Over 100 different rhinoviral serotypes have been identified thus far, establishing rhinoviruses as the most diverse group of Picornaviridae. Based on receptor binding properties, rhinoviruses are divided into two classes: the major group binding to intracellular adhesion molecule-1 and the minor group binding to the very low density lipoprotein receptors. Interactions between virus and the receptor molecules cause a conformational change in the capsid, which is a prerequisite for viral uptake. Rhinoviruses trigger a chemokine response upon infection that may lead to exacerbation of the symptoms of common cold, i.e. asthma and inflammation. The following review aims to summarize the knowledge about rhinoviral infections and discusses therapeutical approaches against this almost perfectly adapted pathogen.     

Telomeres and meiosis in health and disease

Telomeres are important segments of chromosomes that protect chromosome ends from nucleolytic degradation and fusion. At meiosis telomeres display an unprecedented behavior which involves their attachment and motility along the nuclear envelope. The movements become restricted to a limited nuclear sector during the so-called bouquet stage, which is widely conserved among species. Recent observations suggest that telomere clustering involves actin and/or microtubules, and is altered in the presence of impaired recombinogenic and chromosome related functions. This review aims to provide an overview of what is currently known about meiotic telomere attachment, dynamics and regulation in synaptic meiosis.     

From endoderm to pancreas: a multistep journey

The formation of the vertebrate pancreas is a complex process that typifies the basic steps of embryonic development. It involves the establishment of competence, specification, signaling from neighboring tissues, morphogenesis, and the elaboration of tissue-specific genetic networks. A full analysis of this multistep process will help us to understand classic principles of embryonic development. Furthermore, this will provide the blueprint for experimental programming of pancreas formation from embryonic stem cells in the context of diabetes cell-therapy. Although in the past decade many studies have contributed to a solid foundation for understanding pancreatogenesis, important gaps persist in our knowledge of early pancreas formation. This review will summarize the current understanding of the early mechanisms coming into play to pattern the "pre-pancreatic" region within the endoderm and, gradually, specify the pancreatic tissue.