面向对象技术在流域洪水预报系统中的应用

通过对现有的洪水预报系统的分析,确定了复用率低以及难于扩展是目前洪水预报应用系统在实现方面存在的普遍问题。利用面向对象的Java语言作为开发工具,进行洪水预报应用系统的开发,使系统具有较强的可扩展性和复用能力,能有效地缩短新系统的开发周期,因而是进行洪水预报系统开发的有效工具。     

结构化面向对象形式规格说明语言OOZS——设计原理

形式方法与面向对象方法的综合使用可以使它们各自的优点得到充分体现：形式方法使目标软件系统的需求规格说明简明、精确,面向对象方法使目标软件系统的组织和分解工作更加系统、自然．本文讨论了Ｚ规格说明语言的应用限制,并在Ｚ语言的基础上介绍了结构化面向对象形式规格说明语言——ＯＯＺＳ的设计方法．该语言吸收了面向对象程序设计语言ＳｍａｌＴａｌｋ、Ｃ＋＋以及形式规格说明语言ＶＤＭ、Ｚｃ、Ｚ．Ｓ等的优点,引入了类、继承、入口、出口、Ｐｒｅ谓词、Ｐｏｓｔ谓词等机制,并对Ｚ语言的符号进行结构化处理,提高了形式规格说明的层次性和模块化能力,可用于大型面向对象软件系统需求规格说明的编写     

高中数学课型构建与实例分析——以《直线与圆的位置关系》为例

目前高中课堂中的数学课型有概念课、评讲课、知识型课、习题课;选取知识型课为研究对象,从创设情境、引入新知,精选例题、巩固知识,变式迁移、拓展知识,总结方法、归纳知识,课后思考、升华知识这5个方面进行数学课型构建,打造高效的高中数学知识型课堂教学;通过高效的高中数学知识型课堂教学,提高数学课堂教学的效率,完成数学课堂教学目标。     

Digoxin and ouabain increase the synthesis of cholesterol in human liver cells

Digoxin and ouabain are steroid drugs that inhibit the Na⁺/K⁺-ATPase, and are widely used in the treatment of heart diseases. They may also have additional effects, such as on metabolism of steroid hormones, although until now no evidence has been provided about the effects of these cardioactive glycosides on the synthesis of cholesterol. Here we report that digoxin and ouabain increased the synthesis of cholesterol in human liver HepG2 cells, enhancing the activity and the expression of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme of the cholesterol synthesis. This effect was mediated by the binding of the sterol regulatory element binding protein-2 (SREBP-2) to the HMGCR promoter, and was lost in cells silenced for SREBP-2 or loaded with increasing amounts of cholesterol. Digoxin and ouabain competed with cholesterol for binding to the SREBP-cleavage-activating protein, and are critical regulators of cholesterol synthesis in human liver cells. Received 10 January 2009; received after revision 11 February 2009; accepted 6 March 2009     

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

Bile acids and bile alcohols in the form of their conjugates are amphipathic end products of cholesterol metabolism with multiple physiological functions. The great variety of bile acids and bile alcohols that are present in vertebrates are tabulated. Bile salts have an enterohepatic circulation resulting from efficient vectorial transport of bile salts through the hepatocyte and the ileal enterocyte; such transport leads to the accumulation of a pool of bile salts that cycles between the liver and intestine. Bile salt anions promote lipid absorption, enhance tryptic cleavage of dietary proteins, and have antimicrobial effects. Bile salts are signaling molecules, activating nuclear receptors in the hepatocyte and ileal enterocyte, as well as an increasing number of G-protein coupled receptors. Bile acids are used therapeutically to correct deficiency states, to decrease the cholesterol saturation of bile, or to decrease the cytotoxicity of retained bile acids in cholestatic liver disease.     

关于一类Hopf曲面的同调群

给出一类Ｈｏｐｆ曲面陈类的一个详细计算，并对层上同调群的维数和Ｐｉｃａｒｄ群给出一个具体结果     

《金属有机化学》教学心得

金属有机化学是为有机化学专业研究生开设的一门选修课程,本文以作者的教学经历为背景,介绍了课程内容的选取,课堂教学方法,网络课堂的建立和考试方式的改革.总结出一套适用于我系研究生的行之有效的教学方法,即注重课程的引入,课程内容结合实际应用,注重学生思维能力和动手能力的培养.改革考试制度,加大主观题的比例,培养学生归纳总结的能力.     

一个解决网络故障相关性的算法

解决故障相关性是实现故障管理自动化的关键。介绍了网络管理及故障管理的基本概念 ;引入离散数学中的有关理论 ,提出了故障相关图、故障连接图、极大相关类等概念 ,用于研究和描述故障相关性的本质 ;给出了一个解决故障相关性的算法 ,并且证明该算法的时间复杂度为 0 ( n3 ) ;最后 ,以一个例子进一步说明算法的工作原理。     

高级程序语言教学改革新探

从计算机高级语言教学发展的角度,强调了从面向过程的高级语言向面向对象的高级语言教学转变之必然,从而达到教学与社会需求相结合的要求。