老年恶性肿瘤病人化疗中的静脉保护289例

总结289例老年恶性肿瘤病人化疗中的静脉保护，化疗前的准备工作对静脉保护极为重要．同时，掌握好给药顺序，选择好静脉，加强巡视，及时排除输液中的故障，严格无菌操作，对化疗中的静脉炎及药物外漏起到了预防作用．并对3例静脉炎及5例药物外漏给予相应的对症处理，无局部组织溃疡、坏死等并发症，从而顺利完成了老年恶性肿瘤病人的全程静脉化疗，延长了病人的生存期，提高了治愈率．     

多相循环流化床流动规律的研究

研究了影响多相流态化各个参数(包括全床平均气含率、全床平均固含率和液体循环量)的因素,细致地讨论了气液两相及固体颗粒加入时,气含率、液体循环量的变化规律,并且通过实验结果发现,固体颗粒加入后,不会改变全床平均气含率和液体循环量的变化趋势,但是液体循环量显著减少,并且从整个系统能量守恒的基础出发,建立了数学模型,用于对整个多相循环流态化系统进行模拟,模型的预测结果与实验获得的数据平均误差小于5%,可较好地描述多相循环流化床流动规律.     

Inducing dopaminergic differentiation of expanded rat mesencephalic neural stem cells by ascorbic acid in vitro

Ascorbic acid (AA) induced differentiation of neural stem cells (NSCs) into dopaminergic (DAergic) neurons is reported.NSCs derived from rat mesencephalon were maintained and expanded in a defined medium containing mitogens of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF).Compared with the control, ascorbic acid treatment led to more DAergic neuronal differentiation as indicated by the expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT), which are specific markers of dopamine neurons.AA induction also enhanced expression of Nurr1 and Shh.PD98059, an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway, could block AA-induced Nurr1, TH and DAT mRNA expression.The results might suggest a new strategy to provide enough dopaminergic cells for the therapy of Parkinson's disease (PD), and Nurr1 and ERK signaling pathway might participate in the AA-induced DAergic differentiation.     

基于LS-SVM的燃料电池控制建模的研究

由于直接甲醇燃料电池数学模型的复杂性难以满足工程上对DMFC控制系统的设计，提出一种基于最小二乘支持向量机建模算法，用具有RBF核函数的LS-SVM离线建立DMFC电堆的非线性模型；仿真和实验结果表明了该建模方法具有建模简单、模型精度高等优点，亦证明了该算法的有效性和优越性。研究结果对直接甲醇燃料电池控制系统的建模和控制具有一定的实用价值。     

细胞因子诱导的NK细胞过继免疫治疗恶性肿瘤的初步应用

目的　采集不同类型恶性肿瘤患者外周血,扩增CINK细胞,并观察自体CINK细胞过继免疫治疗的疗效和安全性.方法　利用抗CD3 单抗、IL-2、PHA从9 例肿瘤患者PBMC中诱导扩增CINK细胞,2 周左右开始自体回输.结果　CINK细胞经培养后细胞总数和CD3- CD56+NK细胞均获大量增殖.肿瘤患者经自体CINK 细胞免疫治疗后, CD3、CD4 T 细胞、NK 细胞、CD4/CD8的比例均显著提高(P<0.01),睡眠、食欲等指标也有相应改善,治疗过程中未见副作用. 结论　自体CINK细胞过继免疫治疗可以显著提高患者免疫功能,改善患者生活质量,且副作用小.     

构建以合作组织为纽带的农产品流通渠道

从流通组织的角度出发，对我国建立以合作社为中介组织的农产品流通渠道的必要性及存在的问题进行了分析论证，并提出了一些创新的思路。     

新时期高校图书馆流通服务浅议

论述了新时期高校图书馆流通服务工作环境的变化，提出了提高流通服务质量的策略，包括加强读者调研工作，加强馆际互借和资源共享，提高流通服务层次，加强对读者的思想素质教育，建立一支高素质的流通服务工作队伍等。     

Development of the CAS-IBB single-particle microbeam for localized irradiation of living cells

A single-particle microbeam facility has been constructed at the Key Laboratory of Ion Beam Bioengineering (LIBB), Chinese Academy of Sciences (CAS). The system was designed to deliver a defined numbers of hydrogen ions, produced by a van de Graaff accelerator, in an energy range of 2.0-3.0 MeV, into an area smaller than that of the nucleus of an individual living cell. The beam is collimated by a borosilicate glass capillary that forms the beam-line exit. An integrated computer program recognizes the cells and locates them one by one over the microbeam exit for irradiation. We present technical details of the CAS-LIBB microbeam facility, particularly on the collimator, hardware, control program, as well as cell irradiation protocols available. Various factors contributing to the targeting and positioning precision are discussed along with accuracy measurement results.     

超声激活血卟啉对在体艾氏腹水肉瘤的抑制

利用频率为2.0 MHz,强度为5.0 W/cm2的超声激活血卟啉对在体小鼠艾氏腹水瘤细胞 进行了抑癌作用研究.通过对一次和多次处理的肿瘤体积和重量变化趋势的研究,发现声动力疗法 对艾氏腹水瘤细胞增殖有显著抑制作用,且多次处理比一次处理效果更为明显.     

磁场的生物学效应

论述了稳恒磁场抑制肿瘤的生物效应(包括稳恒磁场对肿瘤的直接影响)对免疫功能、自由 基代谢以及对抗癌药物的影响,并对其可能的作用机理进行了分析.