Effect of volatile anesthetics on the circular dichroism of bilirubin bound to human serum albumin

The characteristic circular dichroism of bilirubin bound to human serum albumin undergoes a remarkable sign inversion on addition of halothane, chloroform and other volatile anesthetics. This sign inversion, which is completely reversed by removal of the anesthetic, reflects a pronounced conformational change of the bound ligand; probably a complete inversion of chirality. The observation suggests that association of volatile anesthetics with proteins can markedly alter the internal topography of receptor sites and potentially influence the stereoselectivity of ligand binding.     

The detection of structural deformation errors in attitude determination

In the determination of the attitude parameters from a multi-antenna GPS array, one of the major assumptions is that the body frame is rigid at all times. If this assumption is not true then the derived attitude parameters will be in error. It is well known that in airborne platforms the wings often experience some displacement during flight, especially during periods of initializing maneouvres, such as taking off, landing,and banking. Often it is at these points in time that it is most critical to have the most precise attitude parameters.There are a number of techniques available for the detection of modeling errors.The CUSUM algorithm has successfully been implemented in the past to detect small persistent changes. In this paper the authors investigate different methods of generating the residuals, to be tested by the CUSUM algorithm, in an effort to determine which technique is best suited for the detection of structural deformation of an airborne platform. The methods investigated include monitoring the mean of the residuals generated from the difference between the known body frame coordinates, and those calculated from the derived attitude parameters. The generated residuals are then passed to a CUSUM algorithm to detect any small persistent changes. An alternative method involves transforming the generated residuals into the frequency domain through the use of the Fast Fourier Transform. The CUSUM algorithm is then used to detect any frequency changes. The final technique investigated involves transforming the generated residuals using the Haar wavelet. The wavelet coefficients are then monitored by the CUSUM algorithm in order to detect any significant change to the rigidity of the body frame.Detecting structural deformation, and quantifying the degree of deformation, during flight will ensure that these effects can be removed from the system, thus ensuring the most precise and reliable attitude parameter solutions. This paper, through a series ofsimulations, will assess the effectiveness of the above mentioned techniques for detecting structural deformation effects on a GPS multi-antenna array. These principles are then tested with experimental data.     

网络环境下新型物理教学模式探索

论述了利用意义建构学习理论进行物理教学和网络整合的方法和途径,阐述了网络环境下意义建构物理教学模式的优点.     

影响有机化合物酸碱强度的因素

主要从有机化合物的结构出发,分析和判断了电子效应、杂化方式及空间效应等因素对有机分子酸碱性的影响.     

模式语义链元建模及其应用

大粒度的模型转换是模型驱动软件开发场景下的重要技术需求，仅通过定义通用模型转换语言不足以满足这一需求，其中一个原因是通用模型转换语言工作在特定建模语言的元模型层次而非一般设计意图层次上．文中提出一种模式语义链(PSL)元建模方法．通过重型扩展统一建模语言(UML)元模型以直接形式化描述可表达一般设计意图的模式，并应用UML动作语义和元模型继承实现模式自动生成及转换．该方法为实现一船设计意图层次上的大粒度模型转换提供了有效支持．     

圆电流平面内磁场分布的测量

本文设计了一个测量圆电流平面内磁场分布的实验,实验结果与理论计算能很好地吻合。从而证明该实验设计是可行的。     

结构稳定性在非线性系统鲁棒性分析中的应用

探讨了非线性系统的结构稳定性、分叉点和鲁棒性之间的关系，提出了一种分析非线性系统鲁棒稳定性的方法，并给出了相应的计算实例．     

基于C/S与B/S相结合的教学管理系统的规划

针对当前高等教育体制改革学校办学规模不断扩大,存在多校区的办学模式,原来基于C/S或B/S单一模式结构的教学管理系统存在诸多弊端,对目前高校教学管理的实际需要和特点进行了分析,比较了两种模式的优缺点,提出了一种基于C/s和B/S结合的结构模式的教学管理系统,给出了基于该模式下教学管理系统的功能模块、实现方法、系统的软硬件支撑条件.     

市场营销专业课程体系探索

从市场营销专业人才培养目标出发，分析了市场营销专业课程体系的不足，提出了面向21世纪的市场营销专业课程体系的构建思路。     

基层图书馆工作现状及对策

针对新时期基层图书馆所面临的经费不足、体制僵化、管理观念陈旧等一系列问题，提出了使基层图书馆走出国境、适应新时代发展需要的若干对策。