Methimazole treatment reduces cardiac hypertrophy and mortality without a concomitant reduction in blood pressure in established Goldblatt two-kidney one clip hypertension

The effects of methimazole, and antithyroid drug, on blood pressure and other parameters were evaluated in the established phase of Goldblatt two-kidney one clip (G2K-1C) hypertension. Methimazole was administered via drinking water for five weeks, starting five weeks after hypertension had been induced. After this period of treatment, similarly high blood pressures were observed in methimazole-treated and non-treated G2K-1C rats, despite the fact that a hypothyroid state had been achieved in methimazole-treated rats. Methimazole-treated G2K-1C rats showed reductions in heart rate, ventricular weight, ventricular/body weight ratio and mortality in comparison with rats not treated with methimazole. These results clearly demonstrate that hypothyroidism induced by methimazole: a) does not reverse G2K-1C hypertension, but b) improves the rate of survival and c) reduces relative cardiac hypertrophy, possibly by the reduction in cardiac work observed in Goldblatt hypothyroid rats.     

The effects of acute and chronic morphine on regional distribution of cardiac output in brain

Summary Both acute and chronic administration of morphine resulted in an increase in the percent cardiac output received by brain. However, various brain regions were affected differently by the drug treatments. The greatest increases in percent cardiac output received after chronic administration of morphine occurred in pons and cerebellum, while the greatest increases after acute administration occurred in cortex and midbrain. The changes found are in contrast with earlier studies which suggest that morphine has no effect on cerebral blood flow.     

CT自适应心率变速扫描研究

针对心脏运动导致CT图像的模糊,提出了自适应心率的CT变速扫描方法.该方法可根据心率和所需要的时间可分辨率自适应选择最优的扫描拔,获得理想的投影数据.为了验证该模型,通过分段线性和非线性变形模型仿真心脏运动,利用滤波反投影重建算法进行了心脏图像重建.重建结果表明:根据心率选择合适的扫描速度可得到理想的投影数据,有效地提高了心脏图像质量,从而为CT心脏成像提供新的模式.     

健身气功·八段锦对老年人心肺功能影响

本研究观察经6个月健身气功·八段锦锻炼后对老年人心肺功能的影响．随机选取大连市沙河口区40名健康、无锻炼习惯的退休职工为实验对象,并随机分为实验组和对照组．验组在教师的指导下进行6个月、每天一次的健身气功“八段锦”锻炼．结果显示,与对照组比较,实验组肺活量及肺活量指数显著升高（P〈0．01）;LPET／LVET及平均动脉压明显下降（P〈0．05及P〈0．01）;CO、SV及台阶实验指数显著升高（P〈0．05及P〈0．01）．结果显示,6个月健身气功“八段锦”锻炼对老年人心肺功能的改善具有良好的促进作用．     

心磁和心电信号的混沌时间序列分析

计算了一组心磁和心电检测信号的关联维数和最大李亚普诺夫(Lyapunov)指数.心磁和心电信号的关联维数分别在2.28±0.27和1.12±0.13范围内,最大Lyapunov指数分别在0.68±0.12和0.32±0.04范围内.对其它4组数据中心测点的计算结果也说明心磁和心电信号具有混沌特性.此外,结果显示心磁边缘测点的混沌吸引子与中心部分有明显差别,可用于分析信号的有效检测范围.     

心脏瓣膜置换术后妊娠的处理（附8例）

目的：探讨心脏瓣膜置换术后妊娠的临床情况及处理。方法：分析经治的8例心脏瓣膜置换术后妊娠患者的临床表现、处理及结局。结果：8例心脏瓣膜置换术后妊娠患者经过合理抗凝,适时剖宫产分娩,母婴平安出院。结论：对心脏瓣膜置换术后妊娠患者应予重视,合理抗凝、密切监护,以保证患者在孕期和分娩期的安全。     

基于EMD的心电信号压缩算法

针对生物医学信号特别是心电信号(ECG)的特点和数据压缩需求,提出一种基于经验模态分解(EMD)方法的ECG信号压缩算法.所提算法计算简单,无需预先或后处理.以MIT-BIH标准数据库的心律失常数据作为实验数据,通过压缩比(CR)、均方根百分差异(PRD)、归一化均方根百分差异(PRDN)、均方根(RMS)、信噪比(SNR)、质量评分(QS)6个评价参数分析所提算法性能,并与基于小波分解的压缩算法进行比较.实验结果表明,所提算法具有较好的压缩比与保真度,证明了该算法的有效性.     

黄连素的心血管作用药理及其临床应用

黄连素具有广泛的药理作用,近年来通过实验及临床深入研究发现其对心血管有较好的作用,现就黄连素对心血管作用机理及其临床应用研究进行综述。     

NSTEMI个体化诊疗中同型半胱氨酸、心肌钙蛋白联合检测价值前瞻性研究

目的探讨非ST段抬高型心肌梗死(NSTEMI)个体化诊疗中同型半胱氨酸、心肌钙蛋白联合检测的价值.方法前瞻性选取NSTEMI患者86例为研究组,选取同期体检的86例健康人为对照组,采用酶定量法检测血脂指标,ELISA法检测同型半胱氨酸,乳胶增强免疫比浊法检测心肌钙蛋白水平.结果单一同型半胱氨酸、心肌钙蛋白诊断NSTEMI的灵敏度分别为84.88%,95.35%,特异性分别为90.70%,87.21%;两指标联合检测的灵敏度、特异性升至97.67%,98.84%.ROC曲线分析显示:联合检测AUC明显大于单项检测,差异具有统计学意义(P0.05).研究组治疗后TG,LDL-C、同型半胱氨酸、心肌钙蛋白水平均明显低于治疗前,但仍高于对照组,差异具有统计学意义(P0.05);HDL-C明显高于对照组,但仍低于对照组,差异具有统计学意义(P0.05).同型半胱氨酸含量与TG,LDL-C之间呈明显正向直线相关性(r=0.553、0.377,P=0.000、0.002);同型半胱氨酸含量与HDL-C之间呈明显负相关(r=-0.402,P=0.000).心肌钙蛋白含量与TG,LDL-C之间呈明显正向直线相关性(r=0.637、0.481,P=0.000、0.001);心肌钙蛋白含量与HDL-C之间呈明显负相关(r=-0.402,P=0.000).结论同型半胱氨酸、心肌钙蛋白联合检测可明显提升NSTEMI个体化诊疗的灵敏度和特异性,且与血脂指标存在明显相关性.