抗风湿涂膜剂的制剂研究

研究氮酮和丙二醇在不同体积分数下,对辣椒素和川乌总生物碱的促透影响以及涂膜剂的基质选择.应用改良Franz扩散池装置,通过HPLC法对辣椒素和酸性染色比色法对对川乌总生物碱进行含量测定,对比不同比例的氮酮和丙二醇对它们的促透效果;根据外观透明度、黏稠性和成膜性等确定基质壳寡糖的加入量.氮酮和丙二醇不同组合对辣椒素的促透...     

Central terminals of capsaicin-sensitive primary afferent make synaptic contacts with neuronal soma in the mouse substantia gelatinosa

Degeneration of primary afferent central terminals (C-terminals) that contact neuronal soma in the substantia gelatinosa of the spinal dorsal horn was examined by electron microscopy 2 h after s.c. injection of capsaicin into newborn and adult mice. The C-terminals were small, dark, sinuous or slender terminals with clear synaptic vesicles in the early postnatal period. They are thought to develop into scalloped CI-terminals, surrounded by dendrites and a few axonal endings, forming synaptic glomeruli. The same type of nonglomerular terminals making presynaptic contacts with neuronal soma showed degeneration in both the newborn and adult animals, and were identified as capsaicin-sensitive CI-terminals. This finding suggests that capsaicin-sensitive C-fibers have a modulatory role on their own nociceptive input besides functioning in nociceptive transmission in the substantia gelatinosa.     

辣椒碱应用研究概况

介绍了国内外有关辣椒碱在医药保健、生物农药、化工和军事领域的应用研究概况。