延迟多重休假离散时间的Geomx/G/1可修排队系统的可靠性指标

首次考虑延迟多重休假离散时间成批到达的Geomx/G/1可修排队系统的可靠性指标,在假定到达间隔时间和服务台的寿命服从几何分布,而服务时间、延迟休假时间、休假时间和服务台失效后的修理时间均服从一般离散分布下,使用一种新的分解方法讨论了服务台如下的可靠性问题:1)在时刻n服务台处于"广义忙期"的概率;2)服务台的瞬态和稳态不可用度;3)服务台在(0,n]时间内的平均失效次数;4)服务台在"广义忙期"内的平均失效次数.得到了一系列重要的可靠性结果.     

灰色多变量GM(1,N)幂模型及其应用

针对多变量少数据的系统建模问题,提出了灰色多变量GM（1,N）幂模型及其派生模型GM（1,N,x^（1））幂模型,给出了其参数估计算式和近似时间响应式,在此基础上,分两种情况讨论了模型的参数优化方法,并通过数值模拟和应用实例验证了新模型的有效性. 结果表明：传统的GM（1,N）模型是GM（1,N）幂模型的特殊形式,GM（1,N）幂模型能够更好地描述系统特征行为序列与其影响因素序列的非线性关系,从而有效地提高传统灰色多变量系统建模的精度.     

单增序列灰色GM(1,1)模型解之间的误差分析

针对单调增长原始数据序列, 文章在理论上讨论白化型与内涵型GM(1,1)(grey forecasting model)模型解之间的相对误差. 在推导出两个模型解之间的相对误差上界表达式的基础上, 作者研究了相对误差上界函数的性质, 讨论了相对误差一致上界关于原始数据序列长度n的单调性. 结果表明当发展系数位于[-1/(n+1),0]内时, 白化型与内涵型GM(1,1)模型解之间的相对误差上界是0.9%,可以合理使用白化模型代替内涵模型; 而发展系数在区间[-2/(n+1),0]内时, 这两个模型解之间的相对误差可能达到8.64%, 此时白化模型代替内涵模型须较谨慎地使用.     

Image separation using wavelet-complex shearlet dictionary

This paper presents a new method for image separation through employing a combined dictionary consisting of wavelets and complex shearlets. Because the combined dictionary sparsely represents points and curvilinear singularities respectively, the image can be decomposed into pointlike and curvelike parts as accurate as possible. The proposed method based on the geo- metric separation theory introduced by Donoho in 2005 shows that accurate geometric separation of the morphologically distinct fea- tures of points and curves can be achieved by l1 minimization. The experimental results show that the proposed method can not only be effective but also greatly reduce the computing time.     

常见肝癌细胞系的转铁蛋白受体表达差异分析及主动靶向载体效率比较

转铁蛋白受体1(transferrin receptor 1,TfR1)可介导细胞内吞过程,从而摄取与之特异结合的纳米颗粒,因此成为许多主动靶向型纳米载体的靶点。研究表明,肝癌细胞存在TfR1高表达现象,可作为肿瘤治疗纳米药物递送系统的关键性靶点。体外评价是TfR1靶向纳米载体的重要研究环节,然而肝癌细胞模型种类繁多,其TfR1表达水平可能存在一定差异。选择了几种常见的肝癌细胞系,包括HepG2、Hep3B、MHCC97-H以及Huh-1,分别从mRNA水平以及蛋白水平测定了细胞系TfR1的表达情况,考察了转铁蛋白(Tf)以及转铁蛋白核酸适配体(transferrin nucleic acid aptamer, Tf-APT)对不同细胞的亲和效率。同时,制备了包载紫杉醇的TfR1靶向脂质体,并考察其对不同细胞系的细胞生长抑制作用。结果表明,4种肝癌细胞系在mRNA水平以及蛋白水平均存在TfR1的表达差异;同时,体外抗肿瘤结果显示,不同肝癌细胞系对紫杉醇-TfR1靶向脂质体的敏感性也存在显著不同。     

具有抗氧化活性的两种天然1,5-二芳基戊烷化合物的合成

以香兰素和对羟基苯甲醛为原料经三步或四步反应分别以63%和40%的总产率得到从姜科植物Curcuma domestica的根状茎中提取出来的两种具有很好抗氧化活性的1,5-二芳基戊烷化合物1和2.     

2,3,5-三甲基-5,6-二氢吡嗪脱氢芳构化研究

介绍以丁二酮和1,2-丙二胺为原料,经缩合、脱氢芳构化反应合成2,3,5-三甲基吡嗪的新方法.重点考察了脱氢剂组成、脱氢剂用量、溶剂用量等对反应的影响.确定了合成2,3,5-三甲基吡嗪的优化条件为:以无水乙醇为溶剂,投料比为丁二酮:丙二胺:脱氢剂:无水乙醇=1:0.67:1.4:1.31(质量比);缩合反应温度为20～25℃:回流脱氢4 h,2,3,5-三甲基吡嗪的含量达98%以上.     

基于深度学习的高分六号影像水体自动提取

为了探究高分六号(GF-6)卫星多光谱相机(PMS)影像提取水体的潜力,分别构建全卷积神经网络(FCN-8s)、U-Net及U-Net优化(VGGUnet1、VGGUnet2)4种神经网络进行了水体提取研究.基于水体提取结果对比分析,确定优选模型为VGGUnet1;提出基于组合损失函数FD-water loss(foc...     

Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway

Enhanced cell migration is one of the underlying mechanisms in cancer invasion and metastasis. Therefore, inhibition of cell migration is considered to be an effective strategy for prevention of cancer metastasis. We found that emodin (3-methyl-1,6,8-trihydroxyanthraquinone), an active component from the rhizome of Rheum palmatum, significantly inhibited epidermal growth factor (EGF)- induced migration in various human cancer cell lines. In the search for the underlying molecular mechanisms, we demonstrated that phosphatidylinositol 3-kinase (PI3K) serves as the molecular target for emodin. In addition, emodin markedly suppressed EGF-induced activation of Cdc42 and Rac1 and the corresponding cytoskeleton changes. Moreover, emodin, but not LY294002, was able to block cell migration in cells transfected with constitutively active (CA)-Cdc42 and CA-Rac1 by interference with the formation of Cdc42/Rac1 and the p21-activated kinase complex. Taken together, data from this study suggest that emodin inhibits human cancer cell migration by suppressing the PI3K-Cdc42/Rac1 signaling pathway.Received 7 February 2005; received after revision 11 March 2005; accepted 18 March 2005     

A novel pattern of fast calcium oscillations points to calcium and electrical activity cross-talk in rat chromaffin cells

Slow oscillations of cytosolic calcium ion concentration – – typically originate from release by intracellular stores, but in some cell types can be triggered and sustained by Ca²⁺ influx as well. In this study we simultaneously monitored changes in and in the electrical activity of the cell membrane by combining indo-1 and patch-clamp measurements in single rat chromaffin cells. By this approach we observed a novel type of spontaneous oscillations, much faster than those previously described in these cells. These oscillations are triggered and sustained by complex electrical activity (slow action potentials and spike bursts), require Ca²⁺ influx and do not involve release from intracellular stores. The possible physiological implications of this new pathway of intracellular signalling are discussed.Received 30 July 2004; received after revision 14 October 2004; accepted 1 November 2004