非均匀乳房组织中的超宽带微波探测系统仿真

介绍了一种基于半球模型的早期乳腺癌超宽带微波成像检测方案。收发分离的天线阵方案降低了超宽带成像对天线设计的苛刻要求。仿真考虑了乳房内部组织的不均匀给成像质量带来的影响,采用多视发射天线方案可缓解这一问题。由共焦成像算法给出的4毫米直径肿瘤的成像结果表明该方案对较复杂乳房模型的早期乳腺癌检测是可行的。     

Chromsome aberrations in cattle raised on bracken fern pasture

Summary Thirteen cows maintained on natural bracken fern (Pteridium aquilinum) were analyzed cytogenetically. The frequency of structural chromosome aberrations detected in peripheral blood cells was significantly higher when compared to that detected in animals raised on pasture containing no bracken fern. We discuss the clastogenic action of fern and its synergistic action with infection by type 2 and 4 papilloma virus in the same animals.Acknowledgments. We are grateful to Dr F. J. Benesi, Dr J. L. Guerra and Dr I. L. Sinhorini for performing some of the clinical and pathological analyses; O. P. Ferraz, L. A. Tadeu Dias, L. F. Feitosa and A. M. N. Paiva for technical assistance; and to Dr N. H. C. Castro and Dr C. de Araujo Peres for critical and statistics review, respectively. Research was supported by CNPq FAPESP and CAPES.     

Transfer of oligosaccharide from oligosaccharide pyrophosphoryl dolichol to endogenous acceptor proteins in human breast malignant and normal tissues

Summary We have prepared dolichylpyrophosphoryl-[¹⁴C]-oligosaccharide (Dol-PP-oligosaccharide) from calf thyroid. Microsomal fractions from human breast tissues catalyzed the transfer of labeled oligosaccharide to endogenous acceptor proteins. Malignant tumors showed higher activity of the oligosaccharide transferring enzyme than normal tissue. With kojibiose (Kj), and inhibitor of (Glc₃)-glucosidase, an increase in the radioactivity associated with glycoprotein was observed.     

高频声像图及彩色多普勒血流显像对乳腺良,恶性肿瘤 …

采用高频声像图和彩色多普勒血流显像 ,对 4 5例乳腺肿瘤患者进行鉴别诊断 ,结果显示 :有 35例为乳腺纤维腺瘤 ,10例为乳腺癌 ,均经手术及病理证实 .该仪器对乳腺癌的鉴别及早期诊断均具有较高的临床价值     

术中支气管动脉与肺动脉灌注化疗对预防肺癌术后复发、转移的对比研究

目的 选择更有效的灌注方法，为肺癌的综合治疗提供新的治疗途径。方法 通过术中支气管动脉与肺动脉分别灌注5－氟尿嘧啶（5－FU），其靶器官中5－FU的质量浓度，标本用高效液相层析仪检测（HPLG）。结果 5－FU在支气管动脉灌注组的质量浓度明显高于肺动脉组，有显著的统计学意义（P＜0．001），血浆中的5－FU的质量浓度甚微。结论 术中支气管动脉灌注化疗可使靶器官含有较高的药物浓度，且全身毒副作用明显小于肺动脉灌注组。     

36例低位及超低位直肠癌TME保肛手术治疗分析

目的:探讨低位及超低位直肠癌TME保肛手术的手术可行性及优点.方法:回顾分析我院自2003年3月-2006年6月的36例低位及超低位直肠癌TME的保肛手术治疗情况.结果:无手术死亡,无吻合口漏;有1例发生局部肿瘤复发,占2.7%.19例(52.7%)出现直肠前切除综合征.结论:TME保肛术可以有效降低复发率并保留了肛门功能,应成为低位直肠癌治疗的首选术式.     

100 years of radiobiology: Implications for biomedicine and future perspectives

The development of radiobiology from the very early detection of the biological action of X-rays to the knowledge of today is described in sections on radiation chemistry and biochemistry, mutation and cancer induction, and embryonic damage, as well as the dependence of radiation response on radiation quality and temporal dose distribution (repair) and the interaction with other factors. For medicine radiobiology serves as a basis for radiotherapy and radiological protection. The effect of very low doses, and their possible biopositive effect (hormesis and adaptive response), is also discussed, as are the health hazard of radon, health risks after the Chernobyl accident, and space radiobiology. The radiobiology of the future will be concerned with biomolecular and genetic implications, problems of damage and repair, and connected problems like hormesis.     

CT引导下经胸壁针刺活检与吸引对肺部孤立性肿块诊断的比较

为了比较经胸壁针刺肺活检(TTNB)与经胸壁针刺肺吸引(TTNA)在肺部孤立性肿块诊断中的价值,对同一病例,在CT引导下,先采用弹簧式半自动切割针对肺部肿块行TTNB获取活检组织作病理学检查,再用腰穿针行TTNA针吸组织作细胞学检查.结果显示,37例病人均获得满意的标本。经TTNB确诊者34例,确诊率为91.9％,经TTNA确诊25例,确诊率为67.6％,两者有显著性差异(P<0.01).37例病人中,共有并发症6例,发生率为16.2％,其中术后出现气胸2例,发生出血(咯血或肺内出血)4例.提示TTNB与TTNA均是肺部孤立性肿块诊断安全、可靠的方法,但TTNB的诊断率明显高于TTNA,尤其有利于肺部良性病变的诊断,值得广泛应用.     

Regulatory aspects of low intensity photon emission

Summary Photon emission from unicellular and multicellular organisms has been a subject of study for many decennia. In contrast to the well-known phenomenon of bioluminescence originating in luciferin-luciferase reactions, low intensity emission in the visible region of the electromagnetic spectrum has been found in almost every species studied so far. At present, the nomenclature of this phenomenon has not crystallized and it is referred to by a variety of names, such as mitogenetic radiation²⁹, dark luminescence⁷, low-level chemiluminescence^{20, 36}, and biophotons⁵⁷. Particular attention has been focussed on the relationship between photon emission and the regulation of various aspects of cellular metabolism, although in many cases quantitative data are still lacking. Throughout the history of this field of research the question of a functional biological role of the low intensity emission has been repeatedly raised; this is reflected, for instance, in the heterogeneity of the terms used to describe it. The discussion concerns the possible participation of photons of low intensity in intra- and intercellular communication. This paper reviews literature on the metabolic regulation of low intensity emission, as well as the regulation of photon emission initiated by external light. Furthermore, recent data are discussed with respect to a possible biocommunicative function of low intensity photon emission.     

Increased activity of dipeptidyl peptidase IV in serum of hepatoma-bearing rats coincides with the loss of the enzyme from the hepatoma plasma membrane

Summary The specific activity of dipeptidyl peptidase IV (DPPIV E.C. 3.4.14.-) in the plasma membrane of Morris hepatoma 9121 or hepatoma 7777 was 3.5% and 2.9%, respectively, of that in the plasma membrane of rat liver. The enzyme activity in the serum of hepatoma-bearing rats was 141% (hepatoma 91219) and 162% (hepatoma 7777) of the normal value. cytochemical investigation showed that the DPP IV activity was almost completely absent from the hepatoma cell plasma membrane and was not sequestered within these cells. Indirect immunofluorescence staining with a polyclonal antibody directed against DPP IV indicated that the loss of activity was due to the absence of DPP IV molecules in the plasma membrane. The possibility that the enzyme is transferred from the membrane into the serum as a result of structural alterations is discussed.