试述血站术语规范化

随着血站工作的发展,做好血站术语规范的重要性日益显现出来,术语规范关系到提高血站工作的标准统一性、严谨有效性、社会认可性和法律严肃性。     

妊娠期糖代谢异常118例进行营养指导临床分析

随着我国居民生活水平的提高,近年来糖代谢异常的孕妇比例逐年增加,妊娠期糖尿病的发病率达1.31%～3.75%,这主要与膳食结构不合理及能量过剩有关。妊娠期糖代谢异常会导致母婴并发症增加。资料与方法:对2008年9月—2010年1月在该院门诊的2218例孕妇于孕24～28周开始做糖尿病筛查试验,所有孕妇均在24～28w进行50g葡萄糖筛查(GST),对于GST异常者做口服葡萄糖75g(OGTT)诊断。结果:118例妊娠期糖耐量异常的孕妇,109例控制在正常范围,总有效率为92.37%。其中GIGT为70例,有效率为97.22%;GDM为46例,39例正常,有效率为84.78%。新生儿出生体重2500g～4000g为107例,占90.67%。体重<2500g为3例,占2.54%。体重>4000g为8例,占6.78%。讨论:妊娠期糖尿病指孕妇在妊娠期发生或发现的不同程度的葡萄糖耐量异常或糖尿病。主要与以下几个因素相关:年龄、生活方式、家族史。     

我院中老年教职工血脂调查报告

本文对595名40岁以上知识分子的血清胆固醇和甘油三酯进行了调查统计,其中31人为高胆固醇血症,占5.2％,104人为高甘油三酯血症,占17.5％,30人为混合型高脂血症,占5％。高脂血症的发病率有随年龄增高而增高趋势,且女性高于男性。     

Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain

Small conductance calcium-activated potassium (SK or K_Ca2) channels link intracellular calcium transients to membrane potential changes. SK channel subtypes present different pharmacology and distribution in the nervous system. The selective blocker apamin, SK enhancers and mice lacking specific SK channel subunits have revealed multifaceted functions of these channels in neurons, glia and cerebral blood vessels. SK channels regulate neuronal firing by contributing to the afterhyperpolarization following action potentials and mediating I_AHP, and partake in a calcium-mediated feedback loop with NMDA receptors, controlling the threshold for induction of hippocampal long-term potentiation. The function of distinct SK channel subtypes in different neurons often results from their specific coupling to different calcium sources. The prominent role of SK channels in the modulation of excitability and synaptic function of limbic, dopaminergic and cerebellar neurons hints at their possible involvement in neuronal dysfunction, either as part of the causal mechanism or as potential therapeutic targets. Received 23 April 2008; received after revision 29 May 2008; accepted 4 June 2008     

Molecular Physiology of Mammalian Glucokinase

The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human “diabetes gene". Subsequently, important advances were made in understanding the impact of GCK in the regulation of glucose metabolism. Structure elucidation by crystallography provided insight into the kinetic properties of GCK. Protein interaction partners of GCK were discovered. Gene expression studies revealed new facets of the tissue distribution of GCK, including in the brain, and its regulation by insulin in the liver. Metabolic control analysis coupled to gene overexpression and knockout experiments highlighted the unique impact of GCK as a regulator of glucose metabolism. Human GCK mutants were studied biochemically to understand disease mechanisms. Drug development programs identified small molecule activators of GCK as potential antidiabetics. These advances are summarized here, with the aim of offering an integrated view of the role of GCK in the molecular physiology and medicine of glucose homeostasis. Received 11 June 2008; received after revision 18 July 2008; accepted 30 July 2008     

The PAS-domain kinase PASKIN: a new sensor in energy homeostasis

The PAS domain kinase PASKIN, also termed PAS kinase or PASK, is an evolutionarily conserved potential sensor kinase related to the heme-based oxygen sensors of nitrogen-fixing bacteria. In yeast, the two PASKIN homologs link energy flux and protein synthesis following specific stress conditions. In mammals, PASKIN may regulate glycogen synthesis and protein translation. Paskin knock-out mice do not show any phenotype under standard animal husbandry conditions. Interestingly, these mice seem to be protected from the symptoms of the metabolic syndrome when fed a high-fat diet. Energy turnover might be increased in specific PASKIN-deficient cell types under distinct environmental conditions. According to the current model, binding of a putative ligand to the PAS domain disinhibits the kinase domain and activates PASKIN auto- and target phosphorylation. Future research needs to be conducted to elucidate the nature of the putative ligand and the molecular mechanisms of downstream signalling by PASKIN. Received 2 November 2008; received after revision 10 December 2008; accepted 5 January 2009     

高校中老年教工高血压病的防治

对高校中老年教工的常见多发病──高血压病进行了具体分析，并针对各不同年龄段的患者提出了相应的防治措施。     

智能化血压检测系统的研究

介绍一种以８０９８单片机作下位机控制的智能化血压计，利用远程通讯由５８６上位机进行管理的系统，给出了检测血压原理及电路和采用软件的信号平均技术来实现测量精度的要求     

两种洗衣粉对泥鳅血清EST同工酶表达的影响

为探讨洗衣粉对泥鳅血清同工酶表达的影响,选择两种不同的洗衣粉（代号为AJ、BJ）分别以其24 h半数致死浓度（（LC50））为参考浓度,等差设定四个剂量组（18.25 mg/L,29 mg/L,39.75 mg/L和50.5 mg/L）,采用SDS-聚丙烯酰胺凝胶（PAGE）电泳法研究了洗衣粉对泥鳅血清酯酶（EST）表达的影响.结果表明两种洗衣粉在不同浓度染毒下均使泥鳅血清酯酶（EST）同工酶的酶活性变化显著,两种洗衣粉对泥鳅血清同工酶表达具有一定的影响,且不同洗衣粉对其影响程度不同.     

人体血液流动特性的测定

介绍人体血压测量示波法的原理及其应用，并且比较示波法和听诊法的结果，表明示波法是一种简便可靠的方法。