针灸治疗糖尿病周围神经病变临床研究概况

本文综述了近5年来针灸治疗糖尿病周围神经病变(DPN)的相关临床报道,例举了单一疗法及综合疗法,并结合临床研究,证明针灸是治疗DPN的有效方法,且操作方便,无毒副作用.     

Alzheimer’s disease: the impact of age-related changes in reproductive hormones

Recent findings from the Womens Health Initiative (WHI) have raised considerable concern over prolonged use of opposed and unopposed oral conjugated equine estrogen (CEE), given the increased risk of serious adverse effects, including stroke and venous thromboembolic complications. Furthermore, results from the WHI Memory Study (WHIMS) indicated that over 5 years of therapy with Prempro impaired performance on global cognitive tests and nearly doubled the risk of dementia. These surprising findings were contradictory to cumulative evidence from basic science, epidemiological and some intervention studies suggesting hormone therapy was cardioprotective and could potentially reduce the risk of dementia. This review paper focuses on the neurobiology of estrogen, summarizing the clinical evidence for neuroprotective and cognition-enhancing efficacy of estrogen. Further, the paper briefly discusses variables that may account for the unexpected findings of WHIMS, and offers suggestions for future research.     

健择在晚期软组织肉瘤二线治疗中的作用

目的 :评价健择治疗晚期软组织肉瘤以阿霉素和异环磷酰胺为基础化疗失败的病人。方法 :对国内外文献进行归纳、分析及总结。结果 :系统阐述该领域在国内外研究现状 ,为今后研究起到指导作用。结论 :健择在晚期软组织肉瘤二线治疗中有较好疗效、化疗毒性可耐受。     

The development of gene therapy for diseases of the lung

The development of a successful gene therapy has many stages, including preclinical testing in animal models and proof of principle clinical studies. A variety of diseases affect the lung, which are candidates for gene therapy; this review will mainly focus on the diseases that have attracted the most attention and have therefore yielded the most progress, namely lung cancer and the monogenic disorder cystic fibrosis. Knowledge gained from clinical studies could eventually be applied to more complex lung conditions such as acute respiratory distress syndrome and asthma. In addition, increased gene transfer efficiencies could be obtained by appropriate selection of the gene transfer vector and mode of delivery.Received 8 August 2003; received after revision 10 September 2003; accepted 17 September 2003     

肿瘤生物治疗研究进展

生物治疗是应用生物技术对各种疾病(诸如恶性肿瘤、先天性遗传病、传染性疾病、心血管疾病、风湿免疫性疾病等)进行治疗的一种新的治疗手段。生物治疗研究范围非常广泛,主要包括基因治疗、免疫治疗(过继免疫治疗、疫苗治疗、抗体治疗、细胞因子治疗等)、抗血管生成治疗、干细胞治疗、诱导分化及凋亡、内分泌治疗等,下面主要就肿瘤基因治疗、免疫治疗和抗血管生成治疗的现状和发展进行阐述。     

Role of VEGF in the growth and metastasis of a murine bladder carcinoma

Bladder transitional cell carcinoma is the most common form of carcinoma in the urinary system. Although overexpression of VEGF has been identified in tissue, serum,and urine of patients with bladder cancer, the role of VEGF in transitional cell carcinoma of the bladder has not been clearly elucidated. Here, we dissected the effect of VEGF during bladder tumor growth and progression by modifying a BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine) induced mouse bladder transitional cell carcinoma cell line BTT-T739 by stable transfection of antisense VEGF121 cDNA. The transfection resulted in-more than 80% reduction in VEGF production. The growth of the transduced tumor cells in vitro was not affected, however, these cells formed small or no tumors in vivo. Even in the tumors formed, there were minimal vascularization, extensive necrosis and longer latency compared to those formed by parental cells. The permeability of tumor vasrulatuce and metastatic tumor growth were also significantly suppressed in antisense VEGF cDNA transfected cells. In addition, the transfer of anti-angiogenic gene in a rumbination of sFlk-I and ExTek with electroporation can suppress the tumor growth efficiently. Taken together,these results demonstrated that VEGF plays an important role in bladder tumor angiogenesis and angiogenesis plays an important role in bladder tumor growth and metastasis.     

电视监控系统树形控制网络结构与性能

探讨了大型光纤闭路电视监控系统的控制网络的结构和联网方式．用单 片机实现树形控制网络，具有联网和扩容方便、优先处置灵活、线路阻塞概率 小等优点，对树形网络和总线形网络的线路阻塞概率作了推导和比较，并应 用到大连市中山公安分局站前地区治安管理光纤闭路电视监控网中．     

保守治疗胸内食管胃吻合口瘘八例的体会

胸内食管胃吻合口瘘(以下称吻合口痿)是食管癌切除术后早期死亡的首要原因,其死亡率高达50％左右。对其采用保守治疗或争取时机第二次开胸处理各家意见不一。自1979年6月至1987年5月,作者采用保守治疗8例胸内吻合口瘘,结果7例治愈1例死亡。文中提出由十二指肠管饲为主要途径,以支持营养为核心的综合性保守治疗,同时强调必须坚持斜坡位防止胃液对吻合口的侵蚀至关重要。并认为在应用抗菌素控制感染的同时辅以中药煎剂口服,可促使瘘口愈合,缩短病程。