对高校图书馆开展阅读疗法工作的思考——兼谈《阅读疗法》学习心得

介绍了阅读疗法有关情况,分析了在高校推行阅读疗法的必要性,提出了在高校推行阅读疗法的具体思路。     

Restoration of rat calvarial defects by poly（lactide-co-glycolide）/ hydroxyapatite scaffolds loaded with bone mesenchymal stem cells and DNA complexes

A composite construct comprising of a bone mesenchymal stem cell (BMSC) sheet, plasmid DNA, encoding human bone morphogenic protein-2 (hBMP-2), and poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) sponge was designed and employed in the restoration of rat calvarial defects. To improve gene transfection efficiency, a cationic chitosan derivative, N,N,N,-trimethyl chitosan chloride (TMC), was employed as the vector. The TMC/DNA complexes had a transfection efficiency of 13% in rat BMSCs, resulting in heterogeneous hBMP-2 expression in a 10-d culture period in vitro. In vivo culture of the composite constructs was performed by implantation into rat full-thickness calvarial defects, using constructs lacking pDNA-hBMP-2 or BMSC sheets as controls. Significantly higher heterogeneous expression of hBMP-2 was detected in vivo at 2 weeks for the cell sheet/DNA complex/scaffold constructs, compared with the constructs lacking pDNA-hBMP-2 or BMSC sheets. New bone formation was evident as early as 4 weeks in the experimental constructs. At 8 weeks, partial bridging of calvarial defects was observed in the experimental constructs, which was significantly better than the constructs lacking pDNA-hBMP-2 or BMSC sheets. Therefore, the combination of the PLGA/HA scaffold with BMSC sheets and gene therapy vectors is effective at enhancing bone formation.     

线粒体病的基因治疗

线粒体基因突变导致的线粒体病仍是不治之症,目前只有针对症状的支持性疗法.根治线粒体病只能寄希望于基因治疗.基因治疗的主要目标是修补特定基因突变导致的功能缺陷,或促使异质性的转变,以降低突变型与野生型基因组的比例.所探讨的途径主要包括:①在肽核酸和锌指肽的引导下选择性抑制突变基因组的复制;②利用特定的限制性内切酶去除突变...     

推拿疗法“治未病”的机理探析

通过对中医古代文献和推拿学现代文献的研究，分析总结推拿疗法“治未病”的机理。研究结果表明推拿疗法在预防保健和疾病治疗方面均具有良好的效果。     

现代生物技术应用于医药及生殖生物学领域的研究

论述了现代生物技术应用于医药及生殖生物学领域研究取得的新成果与新进展,包括基因治疗、基因工程药物开发及干细胞应用于生殖生物学领域,对这些新成果进行了评述,展望了其未来发展。     

Tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs

Certain carbohydrate antigens of malignantly transformed cells have been identified as markers for the onset of cancer and have become targets for the development of anticancer vaccine therapies. For tumor antigens, many carbohydrate antigens belong to T-independent (TI) antigens. Carbohydrate conjugated to protein carriers can switch TI antigen to a T-dependent (TD) antigen. Attempts to add an innate immune response element (such as Toll-like receptor ligand) to carbohydrate TI-antigens have also been studied. Glycosylation inhibitors or small interfering RNA have also been used for antitumor and/or antiviral agents. This review aims at describing the vast spectrum of tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs.     

对女大学生几种常见疾病及综合保健疗法的研究

在女大学生中，常会出现月经不调、痛经、缺铁性贫血、神经衰弱等几种疾病。它们彼此关联，互相影响，往往使病程加长、较难治愈。本人经过多年研究，运用综合保健疗法进行治疗，获得了比单纯药物治疗更为满意的疗效。     

针刺治疗前列腺增生55例观察

选用治疗"肉芽组织异常增殖”经验穴,即耳部组穴配合体穴,以调整内分泌结合行瘀化痰法,治疗Ⅱ°以下前列腺增生55例,显效30例,占54.5%;有效23例,占41.8%;无效2例,占3.7%,总有效率96.3%.     

肿瘤治疗新方法的研究现状与未来（I）——光动力化学疗法在肿瘤治疗中的应用

详细介绍了动力学化学疗法（PDCT）的发展历史及肿瘤治疗的光动力学化学原理，并介绍了肿瘤光动力化学疗法这一领域的最新动态。     

SITH耐压容量的控制和调节

分析了SITH结构的掺杂电阻率、N－基区厚度、沟道尺寸以及终端结构对正向阻断电压的影响，分析了其横向自掺杂、沟道尺寸、外延层以及相关因素对栅－阴极击穿电压的影响，讨论了如何进行正向阻断电压和栅－阴极击穿电压的控制和调节。