波纹巴非蛤生物学性状及生态习性的初步观察

引进福建增殖海区采捕的波纹巴非蛤,共取样271颗个体,对其壳长、壳宽、壳高、体重、软组织湿重等进行了测定分析。同时在人控环境条件下,对其生态习性进行了初步观察。结果表明:波纹巴非蛤外型为平扁椭圆形,长度约为高度的2.9倍,长度约为宽度的1.7倍,其壳长、壳宽、壳高、体重、鲜肉重间都存在着线性相关;波纹巴非蛤适栖养于泥砂介质,其干露、湿露状态下的半致死时间分别出现在36～40 h和52～58 h,该蛤对酸碱度的变化不敏感,其盐度适应范围是24～36,其中以30～32为最适。     

BCF的热氧稳定化研究

采用连续实验方法,借助X射线衍射、红外光谱、元素分析、力学测试等技术,系统地研究了热氧稳定化过程中聚丙烯腈纤维序态结构、化学结构与生物碳纤维吸附特性、力学性能的内在关联与作用.研究结果表明:聚丙烯腈基热氧稳定化纤维晶区尺寸、取向指数等结构参数与BCF比表面积、吸附特性及力学性能的优劣具有直接内在联系.在热氧稳定化过程中增加聚丙烯腈纤维热氧稳定化结构转化有益于改善生物碳纤维吸附特性,且与生物碳纤维力学性能的变化密切相关.     

含葡萄糖取代基均三唑并[3,4-b]-1,3,4-噻二唑稠杂环化合物的合成及生物活性研究

以2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖基异硫氰酸酯为原料,与3-烷基/芳基-4-氨基-5-巯基-1,2,4-均三唑2a～2h反应制得了8 个未见报道的3-烷基/芳基-6-(2′,3′,4′,6′-四-O-乙酰基-β-D-吡喃葡萄糖基)氨基均三唑并[3,4-b]-1,3,4-噻二唑化合物3a～3h,并经IR,1H NMR进行了结构表征.初步生物活性测试结果表明,目标化合物对黄瓜赤霉、棉花立枯、玉米大斑、苹果黑斑、花生褐斑和小麦赤霉6种植物原菌繁殖均有不同程度的抑制,化合物3g在50 μg*L-1质量浓度时对小麦赤霉的防效达85%.     

单种群扩散模型的正概周期解

对具有斑块间扩散的单种群Logistic模型进行了研究，分析对于两斑块之间以及一般的n斑块间扩散的单种群模型研究了相应概周期系统的概周期解的存在性，稳定性及唯一性。     

麦积山生态旅游资源及其营销策略

麦积山是首批国家级风景名胜区和4A级旅游区,生态旅游资源十分丰富.而开展生态旅游,则应采取加强生态保护,实现生态旅游的可持续发展;加强宣传促销活动,提高麦积山知名度;确立以生态旅游为主体的多层次、多方位大旅游观,加强与周边景区的合作与联系,扩大客源渠道,提高麦积山的可游览性等营销策略.     

A genetic algorithm on multiple sequences alignment problems in biology

The study and comparison of sequences of characters from a finite alphabet is relevant to various areas of science, notably molecular biology. The measurement of sequence similarity involves the consideration of the possible sequence alignments in order to find an optimal one for which the “distance” between sequences is minimum. In biology informatics area, it is a more important and difficult problem due to the long length (100 at least) of sequence, this cause the compute complexity and large memory require. By associating a path in a lattice to each alignment, a geometric insight can be brought into the problem of finding an optimal alignment, this give an obvious encoding of each path. This problem can be solved by applying genetic algorithm, which is more efficient than dynamic programming and hidden Markov model using commomly now. Foundation item: Supported by Zi-qiang Foundation of Wuhan University and Open Foundation of the State Key-Laboratory of Software Engineering, Wuhan University Biography: Shi Feng(1966-), male, Associate professor, research direction: bioinformatics.     

Structural characteristics and biological functions of the HIV-1 gp120 V3 region

Recent studies demonstrate that the V3 loop of HIV-1 gp120 plays an important role in the attachment of HIV-1 to the target cells. Several amino acids in this domain are involved in the interaction of gp120 with the co-receptors. The V3 loop elicits one of the earliest antiviral antibody responses in HIV-1 infection and has been identified as the principal neutralizing determinant (PND). A subset of antibodies to V3 loop show a broad range of neutralizing activity. Unfortunately, this loop undergoes broad mutation and is one of the hypervariable regions. Mutations of some amino acids in this PND could affect syncytium formation, virus infectivity and neutralization. Knowing the structural characteristics and biological functions of the V3 region could help us to understand mechanism of HIV infection and to develop new strategy against HIV-1. In this review, the structural characteristics, variation and biological functions of the V3 loop as well as immunological responses to the V3 loop are discussed.     

锰超氧化物歧化酶模型化合物的合成、表征及活性检测

研究近年来报道的有关锰超氧化物歧化酶及其活性部位的结构，以苹果酸，酒石酸与碳酸锰作用合成了两种超氧化物歧化酶的模型化合物，进行了红外、紫外谱图的表征，利用邻苯三酚自氧化法检测了它们的生物活性。     

高功率短脉冲激光照射下生物组织内的热传导研究

采用响应时间为1μs的超小型薄膜铂热电阻温度计及日本YOKOGAWA DL2700高速数字示波器，对微秒量级脉冲激光照射下离体动物组织内的热传导进行了实验研究，结果发现：在激光脉宽较短时，组织内出现了非傅时叶导热现象，脉宽越短，组织厚度越薄，非傅时叶导热特征越明显，功率密度和光斑直径只影响温度上升的高低，对是否会出现非傅里叶导热没有影响。     

4-氨基-1,2,4-三唑-3-酮席夫碱合成及毒性

以自制的4－氨基－1，2，4－三唑－3－酮为原料，分别与取代的芳香醛反应，采用已有的合成方法设计合成了8个席夫碱类化合物，所有化合物通过^1H NMR,IR，元素分析和熔点测试，确定了化合物的分子结构，初步测定了它们在不同浓度下对金黄色葡萄球菌、大肠杆菌的抑制作用。测试结果表明，部分化合物对金黄色葡萄球菌有较好的抑制作用。