A genetic algorithm on multiple sequences alignment problems in biology

The study and comparison of sequences of characters from a finite alphabet is relevant to various areas of science, notably molecular biology. The measurement of sequence similarity involves the consideration of the possible sequence alignments in order to find an optimal one for which the “distance” between sequences is minimum. In biology informatics area, it is a more important and difficult problem due to the long length (100 at least) of sequence, this cause the compute complexity and large memory require. By associating a path in a lattice to each alignment, a geometric insight can be brought into the problem of finding an optimal alignment, this give an obvious encoding of each path. This problem can be solved by applying genetic algorithm, which is more efficient than dynamic programming and hidden Markov model using commomly now. Foundation item: Supported by Zi-qiang Foundation of Wuhan University and Open Foundation of the State Key-Laboratory of Software Engineering, Wuhan University Biography: Shi Feng(1966-), male, Associate professor, research direction: bioinformatics.     

Structural characteristics and biological functions of the HIV-1 gp120 V3 region

Recent studies demonstrate that the V3 loop of HIV-1 gp120 plays an important role in the attachment of HIV-1 to the target cells. Several amino acids in this domain are involved in the interaction of gp120 with the co-receptors. The V3 loop elicits one of the earliest antiviral antibody responses in HIV-1 infection and has been identified as the principal neutralizing determinant (PND). A subset of antibodies to V3 loop show a broad range of neutralizing activity. Unfortunately, this loop undergoes broad mutation and is one of the hypervariable regions. Mutations of some amino acids in this PND could affect syncytium formation, virus infectivity and neutralization. Knowing the structural characteristics and biological functions of the V3 region could help us to understand mechanism of HIV infection and to develop new strategy against HIV-1. In this review, the structural characteristics, variation and biological functions of the V3 loop as well as immunological responses to the V3 loop are discussed.     

锰超氧化物歧化酶模型化合物的合成、表征及活性检测

研究近年来报道的有关锰超氧化物歧化酶及其活性部位的结构，以苹果酸，酒石酸与碳酸锰作用合成了两种超氧化物歧化酶的模型化合物，进行了红外、紫外谱图的表征，利用邻苯三酚自氧化法检测了它们的生物活性。     

瑞香亭等化合物对昆虫的生物活性测定

采用叶碟法，用瑞香亭（daphnoritin)、伞形花内酯（7-hydro-coumarin)和狼毒色原酮（cha-mechromone)3种化合物对菜粉蝶（Pieris rapaeL.)5龄幼虫处理1d和2d后的拒食作用和7d后死亡率进行了测定。结果表明：瑞香亭，伞形花内酯和狼毒色原酮对菜粉蝶5龄幼虫都具有较强的生物活性，且随着时间的延长，其生物活性增强，瑞香亭对菜粉蝶5龄幼虫的生物活性与伞形花内酯的生物活性相当，且狼毒色原酮的生物活性最低。     

中学生物教学法教学内容的完善与实施

在素质教育的今天,特别是实施“3+x”升学考试制度以来,高师生物专业的学生如何更好的为我国的基础教育服务,以及如何适应今后的工作和生活,是一个重要的研究课题.本文从中学生物教学法课程着手,结合中学生物教学的实际,探讨了中教法的理论教学和实践教学与中学生物教学相适应的对策,同时也对高师生物教育提出了新的要求.本文倡导理论与实践相结合的方法,重视实际教学过程中能力的培养与体现,完善中教法教学内容和实施方法,希望能给高师生物教学以借鉴.     

两柄蓼(Polygonum amphibium)在不同水条件下的生物学特性的研究

本文首次报道了两栖蓼有三种类型植株以及各种类型植株间随水条件变化而转化的情况。对两栖蓼各类型植株能否开花,是否具酸味以及两栖蓼分类学问题进行了探讨。     

约束逼近的特征问题（综述）

近几十年来,带约束条件的一致逼近受到人们的重视,国内外大量文献对约束逼近中的各种问题进行了研究,本文主要介绍约束最佳逼近的特征问题的研究概况及最新发展。     

格值半连续映射的乘积式刻划

首先构造了一个反例,说明用积空间的开子集刻划通常下半连续函数的情形对一般的格值半连续映射不必成立.然后讨论了用X×L的子集刻划格值半连续映射的各种情形,并且通过在X×M(L)上引入新的拓扑,给出了格值半连续映射的几个刻划定理.     

N3^—杀虫效应的确定

本从Ｎ×－３的结构，电子组态，价键出发来说明它所具有的高度活泼性和生物学效庆，交用酶学试验和杀虫效果来证实；对Ｎ＾－３的杀虫机制，特点进行了探讨；对Ｎ＾－３的杀虫应用前景也作了估计。