The annexins: spatial and temporal coordination of signaling events during cellular stress

Annexins are a family of structurally related, Ca²⁺-sensitive proteins that bind to negatively charged phospholipids and establish specific interactions with other lipids and lipid microdomains. They are present in all eukaryotic cells and share a common folding motif, the “annexin core”, which incorporates Ca²⁺- and membrane-binding sites. Annexins participate in a variety of intracellular processes, ranging from the regulation of membrane dynamics to cell migration, proliferation, and apoptosis. Here we focus on the role of annexins in cellular signaling during stress. A chronic stress response triggers the activation of different intracellular pathways, resulting in profound changes in Ca²⁺ and pH homeostasis and the production of lipid second messengers. We review the latest data on how these changes are sensed by the annexins, which have the ability to simultaneously interact with specific lipid and protein moieties at the plasma membrane, contributing to stress adaptation via regulation of various signaling pathways.     

微量添加元素对Al-Zn-Mg合金时效动力学的影响

利用电阻法研究了单独或同时添加微量元素Mn、Cu和Zr等对Al-Zn-Mg合金时效动力学的影响,结果表明:Mn、Cu和Zr都不同程度地推迟了GP区的形成过程,即延迟GP区的形成速度。并且判定:Cu参加GP区的形核过程;Mn可能参加GP区的形核过程;而Zr不参加GP区的形核过程,但固溶处理时形成的含Zr微细析出物在时效时可能起GP区的核心作用。     

瓦斯超限手机短信报警系统在煤矿安全生产中的应用

阐明了建立瓦斯超限手机短信报警系统的目的和意义，概括了瓦斯超限手机短信报警系统的技术原理，通过实例说明了该系统的应用效果。     

高校办公室管理职能的创新

在追求和谐发展的今天,高校办公室要拓宽办公室职能,树立以人为本的思想,围绕学校中心,承担好收集信息、辅助决策、沟通协调、传播信息、提供服务等职责。     

基于WebSphere MQ的MIS系统的研究与实现

MIS系统学子归家系统以IBM的WebSphere MQ为通讯中间件,可提高整个系统的效率、安全性以及稳定性,并且实现短信模块,方便学校和家长之间的消息沟通和交流,让家长能了解学生上学、放学的动态情况.     

Optimization of Communication for Commanding and Controlling Systems

This paper mainly discussed some special requiremen ts for communication system and specific implement methods during the cause of cam paign cooperation in modern times. That system is the Advanced Field Tactical Da ta System which was developed to meet the requirements for controlling every fir e nodes, through which Army can achieve their campaign and tactical goals. The c ourse of dealing with communication message mainly include Emery‘s situation rep orted, Message change (generally referred to taxis a...     

论现代书籍装帧的特征

书籍装帧艺术在人们精神文化生活方面占有重要地位．从设计思想、视觉效果和生产技术几个角度分析了现代书籍装帧艺术应具备的特征：具有强烈的视觉冲击力，并注重设计性，突出艺术个性，达到艺术和技术的统一．     

图书史研究中需要注意的几个问题

从图书馆学的角度出发,对中国图书史研究过程中需要注意的几个问题,如旋风装新旧说之争、造纸术和雕版印刷术的发明时间等予以了分析和探讨,最后提出了自己的倾向性的观点。     

氯化钠和醋酸钙镁两种融雪剂对土壤中典型重金属结合态的影响

采用实验室模拟方法, 分别用氯化钠（NaCl）和醋酸钙镁（CMA）两种常见的融雪剂液浸泡和淋溶土壤, 并用Tessier连续萃取法测定土壤中Zn和Cu两种重金属各结合态质量比的变化, 考察两种融雪剂对土壤中典型重金属结合态的影响. 结果表明： NaCl融雪剂比CMA融雪剂对土壤重金属影响更明显, 且NaCl的浓度越高差别越大; 土壤中的Zn和Cu在融雪剂浸泡作用下都倾向于转化为可交换态, 可交换态Zn最多增加115%; 融雪剂淋溶作用对Zn结合态影响较大, 其可交换态、 碳酸盐结合态Zn比蒸馏水淋溶分别降低了30%,20%; 对Cu结合态影响较小; 两种金属的有机/硫化物结合态和残渣态受融雪剂浸泡和淋溶的影响均很小; CMA比NaCl融雪剂对环境更友好.