A NEW DESCRIPA NEW DESCRIPTOR OF AMINO ACIDS BASED ON THE THREEDIMENSIONAL VECTOR OF ATOMIC INTERACTION FIELD

QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) IS A VERY IMPORTANT TOPIC FOR MANY SCIENTIFIC FIELDS AND CAN BE TERMED AS QUANTITATIVE SEQUENCE ACTIVITY MODELS(QSAM)[1] WHEN REFERRED TO THE RESEARCH ON RELATION- SHIPS BETWEEN STRUCTURES AND ACTIVITIES OF BIOLOGICAL MOLECULES, SUCH AS PROTEINS, AND NUCLEIC ACIDS. HOW- EVER, IT IS VERY DIFFICULT TO ESTABLISH A QSAM MODEL,…     

多维函数全局寻优的团队进步算法

通过模仿团队进步需要的学习、探索行为和成员更新规则,提出了一种新颖的双群体演化算法,称为团队进步算法(TPA).算法将一个团队的成员分为精英和普通组,建立了两组的学习样板,定义了学习和探索运算,并合理设定了成员更新规则.两组成员在搜索过程中出现了明显分工,使算法兼备了全局搜索、局部搜索和定向搜索的能力.数值试验结果验证了新算法具有实现简单、全局寻优成功率高、收敛快、计算量少、坚韧性强和参数选择相对容易等特性,对解决优化应用问题具有较大的价值.     

Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

浅析供热计量收费计算原理与方法

介绍了热量计量的基本原理和热费确定的基本原则,阐述了供热总费用的构成与计算原理以及用户热费的构成与计算原理。     

工程中常用的几种氧化沟及其发展

简要介绍了当今工程中常用的几种氧化沟技术的特点及其发展历程,主要包括Carrousel氧化沟、Orbal氧化沟、交替式氧化沟以及一体化氧化沟。     

基于模型的飞行控制系统一体化设计技术研究

飞行控制系统设计是一项复杂的系统工程,涉及众多的专业。为了提高系统开发效率,采用MATLAB软件构建了统一的设计平台,使得各专业能够借助平台开展相关设计工作。飞行控制系统一体化设计思路来源于基于模型的设计思想。采用基于模型的设计流程,能够快速完成设计迭代,缩短产品研制周期。作者从飞行控制系统设计的角度,对采用MATLAB软件构建的一体化设计平台及涉及的相关专业技术进行了研究,供广大工程设计人员借鉴。     

基于手机的无线搜索技术

无线搜索已成为一个新的研究、开发领域.并且它主要用到信息检索、人工智能、数据挖掘、自然语言处理、排序算法等多领域的理论和技术.此外,它拥有大量的用户,有很好的经济价值,所以引起了世界各国计算机科学界和信息产业界的高度关注,目前的研究、开发十分活跃,并出现了很多值得注意的动向.     

高分辨率谱估计算法MUSIC和Minimum-Norm及性能比较

本文从理论上详细叙述了高分辨率谱估计技术MUSIC和Minimum-Norm算法的机理,给出并比较了它们的空域谱平坦度、3dB谱宽度和谱峰值随信噪比的变化情况.文章对工程设计人员加深理解、选择算法具有一定的参考意义.     

并行算法软件库PASL

本文介绍了并行算法软件库ＰＡＳＬ。ＰＡＳＬ库运行在具有共享存储的多处理机上，它可以用于科学工程计算和仿真。