邢钢焦化厂水质稳定剂

介绍了根据邢钢焦化厂的水质，经静态阻垢试验，旋转挂片腐蚀试验筛选水质稳定剂配方的过程及实际应用情况。试验及结果表明，LG－1配方具有良好的阻垢缓蚀性能。     

用于图象增强的侧抑制网络模型的仿真比较

侧抑制原理及侧抑制网络在工程上有着广泛的应用，在用于图像增强方面，需要从侧抑制网络模型，抑制系数分布、抑制野范围三方面考虑，选择合适的模型和参数，从而达到 突出边框，加强反差的效果，根据侧抑制数学 模型的分类规则，本文基于前人根据生理实验建立的数学模型综合出一种新的模型并选择双峰高斯曲线作为抑制系数分布函数，通过对这些模型及参数的计算机仿真实验，比较了它们在网络运行速度及边框突出程度方面的差异。     

CagA阳性幽门螺杆菌感染与消化性溃疡、胃炎相关性512例临床分析

目的探讨CagA阳性Hp感染与消化性溃疡、胃炎等胃及十二指肠疾病的关系.方法采用ELISA法对Hp阳性(~(13)C-呼气试验为阳性)、胃黏膜快速尿素酶联免疫法阳性的512例胃十二指肠疾病患者及80例对照者(健康体检:~(13)C-呼气试验为阴性、胃黏膜快速尿素酶联免疫法阴性)行血清CagA抗体检测.512例胃十二指肠疾病患者中慢性浅表性胃炎(CSG)184例,慢性萎缩性胃炎(CAG)120例,十二指肠球溃疡(DU)100例,胃溃疡(GU)108例.结果 CagA抗体阳性检出率对照组为30%,慢性浅表性胃炎组阳性率为61.96%,慢性萎缩性胃炎组阳性率为63.33,十二指肠溃疡组阳性率为68.00%,胃溃疡组阳性率为74.07%.胃十二指肠疾病患者CagA阳性总检出率为66.02%,与对照组比较,差异具有统计学意义(P0.05).结论胃十二指肠疾病Hp阳性感染者中CagA抗体阳性总检出率明显高于对照组,提示CagA抗体阳性感染与胃十二指肠疾病密切相关;两组胃炎患者CagA抗体阳性检出率明显高于对照组,提示CagA抗体阳性感染与胃炎密切相关;胃十二指肠溃疡患者CagA抗体阳性检出率明显高于对照组,提示CagA抗体阳性感染与消化性溃疡密切相关.     

基于侧抑制系数的红外图像细节增强算法

针对红外图像对比度低、细节不清晰和视觉效果模糊的缺点,提出了基于侧抑制系数的红外图像细节增强算法。通过分析指数分布侧抑制系数计算方法的不足,提出利用二次函数分布计算侧抑制系数的方法,提高算法增强红外图像细节的能力,利用红外图像本身的灰度信息自适应地调整侧抑制系数的参数,进而自适应确定侧抑制网络,对图像目标和背景进行不同程度的抑制,结合临界可偏差(just noticeable difference,JND)曲线中得到的人眼视觉分辨率特性,对图像进行能量恢复调整,使图像均值保持在人眼适宜观察的状态。仿真结果显示,与自适应指数函数侧抑制算法相比,算法处理后的红外图像对比度、信息熵以及信噪比都得到提高,图像细节更加清晰,视觉效果得到明显改善。     

Inhibition of bromophenols against PTP1B and anti-hyperglycemic effect of Rhodomela confervoides extract in diabetic rats

Protein tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator in insulin signaling pathways. PTP1B is an effective target for the treatment of type 2 diabetes mellitus. Four bromophenol derivatives from red algae Rhodomela confervoides, 2,2′,3,3′-tetrabromo-4,4′,5,5′-tetra- hydroxydiphenyl methane (1), 3-bormo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl) pyrocatechol (2), bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (3) and 2,2′,3-tribromo-3′,4,4′,5-tetrahydroxy-6′-ethyloxy- methyldiphenylmethane (4) showed significant inhibitory activity against PTP1B (IC50 were 2.4, 1.7, 1.5 and 0.84 μmol/L, respectively) as potential therapeutical agents for the treatment of type 2 diabetes mellitus. The anti-hyperglycemic effects of the ethanol extracts from R. confervoides on streptozoto- cin-induced diabetes (STZ-diabetes) in male Wistar rats fed with high fat diet were investigated. The STZ-diabetic rats treated with medium-dose and high-dose alga extracts showed remarkable reductions in fasting blood glucose (FBG) as compared with the STZ-diabetic control. The results indicate that the in vivo anti-hyperglycemic activity of the R. confervoides extracts can be partially attributed to the in- hibitory actions against PTP1B of the bromophenol derivatives and that may be of clinical importance in improving the management of type 2 diabetes mellitus.     

兔抗小鼠IgG-HRP酶标抗体的制备及应用

制备并纯化小鼠腹水IgG,鉴定IgG纯度;免疫新西兰大白兔制备兔抗小鼠IgG的抗血清并纯化血清IgG;用改良过碘酸钠法制备兔抗小鼠IgG酶标抗体,对其进行鉴定,并与市场上的同类产品对比。结果,纯化的小鼠腹水IgG,其纯度约为80%—90%;免疫新西兰大白兔所制备的抗血清免疫双扩散效价在1：32以上;用改良过碘酸钠法制备酶标兔抗小鼠IgG酶标结合物与市场同类产品相比质量优良,特异性较强,亲和力较好,并在较长时间内效价稳定。结果表明,制备的小鼠IgG抗血清和酶标抗体,适合于小鼠的血清学检测体系的建立。     

一种基于改进的免疫克隆选择的优化方法

通过在克隆选择过程中引入聚类竞争机制,提出了一种免疫聚类竞争的克隆选择算法.采用了抗体聚类、竞争扩增、克隆删除、体细胞高频变异、抗体循环补充等思想及相关算子操作,增强聚类族中的优秀个体获得克隆扩增实现亲和力成熟的机会,提高抗体群分布的多样性,在深度搜索和广度寻优之间取得了平衡.实验仿真及应用结果表明:该算法具有可靠的全局收敛性及较快的收敛速度,将其应用于冶金过程目标优化中取得较好的效果.     

Feasibility Study of Aluminum Hydroxide Sol as Adjuvant to Prepare Stable Vaccine Using Newcastle Disease Virus as a Model

Aluminum hydroxide sol (consisting of aluminum hydroxide nano-particles) prepared by a hydrothermal method was used as nano-aluminum adjuvant adsorbed the inactived Newcastle disease virus (NDV). The zeta potential of aluminum hydroxide colloidal particles,the inactivated NDV and the nano-aluminum adjuvant NDV are +48.16 mV,?13.8 mV and +39.97 mV,respec-tively. The nano-aluminum adjuvant vaccine was transparent and stable without precipitate,whereas the conventional aluminum ad-juvant vaccine was turbid and a white precipitate was visible soon. The hemagglutination inhibition (HI) titers of the nano-aluminum adjuvant group were generally higher than those of the conventional aluminum group except the titer on day 29. The results show that the nano-aluminum adjuvant has better stability and higher levels of antibodies for a longer time than the conventional aluminum adjuvant.     

hKv4．3基因中抑制序列功能的研究

目的：研究基因中抑制序列对离子通道基因表达的影响．方法：我们将hKv4．3基因的启动子和5’非翻译区的一段序列（＋2-＋160，S160）以不同的位置和方向克隆到报告质粒pβ-gal-Basievector中，瞬时表达，进行β—galactosidase相对活性分析．结果：S160对hKv4．3基因表达具有强烈的抑制作用．结论：抑制序列S160对hKv4．3基因的抑制功能具有位置特异性．