宇宙的拓扑结构及应用

宇宙的拓扑结构及应用杨旭（四平师范学院）关键词宇宙，拓扑，模型通过对几何公理内在矛盾的分析和近代科学发展内在逻辑之探讨，本文揭示了宇宙的拓扑结构并提出一个全新的宇宙模型，从而对宇宙奇点，有限无限以及黑洞与白洞的问题给出更为合理的解答．在奇点处被消灭的...     

组织和个体激励效益合理最大化的规划模型

激励是人力资源管理中的一项重要职能 ,激励是有投入与产出的管理活动 .文章通过定义激励过程中的组织和个体的激励效益及其合理最大化的概念 ,建立了一个组织激励效益和个体效益合理最大化的规划模型     

Duane模型、分组数据的AMSAA模型和具丢失数据的AMSAA模型——Bayes分析方法

本文将Bayes分析方法应用于Duane可靠性增长模型、分组数据的AMSAA模型和具丢失数据的AMSAA模型,得到了参数以及系统能达到的MTBF的Bayes点估计和Bayes区间估计。     

MARKOV DECISION PROGRAMMING-THE FIRST PASSAGE MODEL WITH DENUMERABLE STATE SPACE

In this paper,we discuss MDP with discrete time parameter-the firstpassage model with denumerable state space.Under assumption A in this paper,we prove that an ε(>0)-optimal stationary policy exists.To find an ε-optimalstationary policy,an algorithm of policy improvement iteration and a method ofsuccessive approximations are given.     

系统结构模型分部的底层要素法

本文从系统的底层要素出发，提出并证明了底层要素存在性、底层要素后果集并集的完全性以及它们在同一部分的充分必要条件，由此导出了系统结构模型分部的算法，实际应用进一步说明了这一方法的有效性。     

Induction of hemopoietic chimerism in the caprine fetus by intraperitoneal injection of fetal liver cells

Summary Intraperitoneal injection of allogeneic liver cells from 43-day-old male fetuses into normal 60-day female goat fetuses resulted in persistent hemopoietic chimerism in surviving recipients without clinical evidence of graft-versus-host disease. Transplantation of normal fetal liver cells into preimmunocompetent goat fetuses affected with -D-mannosidosis may provide an alternative strategy for evaluating hemopoietic stem cell transplantation in the treatment of human lysosomal storage diseases.     

Evaluation of the hepatotoxicological effects of a drug in an in vivo/in vitro model

Both in vivo and in vitro models have certain disadvantages for the study of the chronic hepatotoxicity of drugs. The aim of this work was to evaluate a new approach based on an in vivo/in vitro model. After chronic in vivo treatment of rats with Vincamine and Vindeburnol (an eburnamenine derivative which exhibits hepatotoxic properties in man) liver cells were isolated, and functional and metabolic disorders (metabolic utilization of fructose and protein biosynthesis) were studied to determine injury. The results showed no modification of blood parameters, but a direct relationship between the dose of Vindeburnol administered in vivo and the metabolic disorders observed in vitro, evidencing the high sensitivity and reliability of this model.     

A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice

Summary The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of ¹-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.We thank the National Institute on Drug Abuse for supporting this project by grants DA-02043 and DA-02052 and for supplying all of the cannabinoids. One of us (S.B.) is also the recipient of a Research Scientist Award from NIDA. We are grateful to Kristen Carlson and Thomas Honeyman for helpful suggestions in preparing this report.     

The Development and Application of Combined Thermoregulatory Mathematical Models

Thermoregulatory mathematical models have being developed for more than half a century and obtained more and more wide application. Among them, the "engineering-physiological" thermal models, which correlated closely to the man-machine-environment system, are the ones that developed most rapidly and have been widely accepted by thermal physiologists and environmental control engineers.This paper attempts to outline briefly the development and application of such kind of thermal models, discusses how to further develop and apply various combined thermal models in practice, and puts forward four respects of suggestions for establishment and modification of combined thermal models of man-clothing-cabin environment.     

Bovine microvascular endothelial cells of separate morphology differ in growth and response to the action of interferon-γ

Five cell types recently isolated from the bovine corpus luteum differed in their epithelioid morphology and their cytoskeleton, but shared common criteria of microvascular endothelial cells^1,2. To give strong evidence for the separate entity, the growth rate of the 5 phenotypically different cells was studied. They were seeded at low density on day 0. Most of these cells were treated with 200 to 1000 U recombinant bovine interferon- (IFN-) for 3 days. The untreated remainder served as controls. Cell counts were made for all cultures on days 4, 7, 10 and 13. morphology: 13 d after treatment with IFN- senescent cells as well as intact cells occurred in cultures of cell types 1 to 4. Cultures of cell type 5 were apparently unchanged and resembled their untreated counterparts. Desminpositive cells in cultures of cell type 2 developed cell processes. Growth rate: In the absence of IFN-, the growth rate was high for cell types 3 and 4, moderate for cell type 1, and low for cell types 2 and 5. The presence of IFN- caused anti-proliferative effects. These were higher for cell types 3 and 4 than for cell types 1 and 2. IFN- could be cytotoxic on cell type 3. In contrast, the cytokine tended to support the cell growth of cell type 5. These findings substantiate the postulate that endothelial cells exhibiting separate morphology in culture also function differently.