Antiquitin, a relatively unexplored member in the superfamily of aldehyde dehydrogenases with diversified physiological functions

Antiquitin is a member of the aldehyde dehydrogenase superfamily. Sequence analyses indicate that the protein is highly conserved from plants to animals. The plant antiquitins are generally believed to play a role in osmoregulation and/or detoxification. The physiological functions of animal antiquitins remain largely elusive, their involvement in a number of human diseases has been implicated. Received 28 February 2006; received after revision 13 July 2006; accepted 31 August 2006     

超声波和Zn/蒙脱石-ZnCl2使芳香醛片呐醇化

用超声波照射Ｚｎ/蒙脱石 ＺｎＣｌ_2和含50%(质量分数)ＴＨＦ的一些芳香醛水溶液2～3ｈ,芳香醛发生偶联反应,生成片呐醇,产率为23%～87%。2,4 二氯苯甲醛、β 苯基丙烯醛发生偶联反应时,片呐醇产率分别达到87.1%和74.8%;对甲基苯甲醛、糠醛发生偶联反应时,化学选择性较好;Ｚｎ/蒙脱石 ＺｎＣｌ_2重复使用3次,活性无显著降低。     

Isoquinolines,beta-carbolines and alcohol drinking: Involvement of opioid and dopaminergic mechanisms

Summary Two classes of amine-aldehyde adducts, the tetrahydroisoquinoline (TIQ) and beta-carboline (THBC) compounds, have been implicated in the mechanism in the brain underlying the addictive drinking of alcohol. One part of this review focuses on the large amount of evidence unequivocally demonstrating not only the corporeal synthesis of the TIQs and THBCs but their sequestration in brain tissue as well. Experimental studies published recently have revealed that exposure to alcohol enhances markedly the endogenous formation of condensation products. Apart from their multiple neuropharmacological actions, certain adducts when delivered directly into the brain of either the rat or monkey, to circumvent the brain's blood-barrier system, can evoke an intense and dose-dependent increase in the voluntary drinking of solutions of alcohol even in noxious concentrations. That the abnormal intake of alcohol is related functionally to opioid receptors in the brain is likely on the basis of several dinstinct lines of evidence which include: the attenuation of alcohol drinking by opioid receptor antagoists; binding of a TIQ to opiate receptors in the brain; and marked differences in enkephalin values in animals genetically predisposed to the ingestion of alcohol. Finally, it is proposed that the dopaminergic reward pathways which traverse the meso-limbic-forebrain systems of the brain more than likely constitute an integrative anatomical substrate for the adduct-opioid cascade of neuronal events which promote and sustain the aberrant drinking of alcohol.     

邻接氢拓扑指数的应用

基于邻接矩阵和原子特征值Ai，建构邻接氧拓扑指数^nH=∑（AiAjAk…）^0.5.其中，^0H与脂肪醇的溶解度（-lg Sw）、辛醇／水分配系数（lg Kcw）、对藤壶幼虫的麻醉活性（pC）的相关系数分别为0.9903，0．9932，0．9908，均优于文献方法．^0H及定位基参数（声）与脂肪醇在6种固定相上的气相色谱保留指数（I）的相关系数都大于0．99．结果表明，所提出的邻接氢拓扑指数具有结构选择性高、性质相关性好以及计算简单、使用方便等优点，是一种较为理想的拓扑指数，所建立的定量结构与性质／活性／保留关系模型相关系数高、稳定性好，可用于脂肪醇性质/活性／保留的预测．     

香草醛改性壳聚糖制备的研究

在水溶液中,壳聚糖与香草醛发生希夫碱反应,生成改性壳聚糖ＶＣＧ。ＶＣＧ的接枝率与反应时间、反应温度、接枝单体的加入量有关,最高可以达到５２％。反应的表观活化能为６．６４ ｋＪ／ｍｏｌ。通过红外光谱分析,可初步确定ＶＣＧ的分子结构。     

离子液体中 Sc（OTf）3催化下苯并［f ］喹啉-1，2-二羧酸酯的合成

在离子液体中，以芳醛、2-萘胺和丁炔二酸酯为原料，在 Sc（OTf）3催化下，通过 Povarov 反应，一步合成了3-芳基苯并[f]喹啉-1，2-二羧酸酯衍生物。产物结构均经红外、氢谱和高分辨质谱确定。与其它方法相比，该方法具有反应条件温和、产率较高和环境友好等优点。     

缩聚-扩链法合成脂肪族聚酯酰胺

采用己二酸、丁二醇及尼龙-66盐的熔融缩聚,制备低分子量的聚酯酰胺预聚体(PrePEA),以1,4-双(2-噁唑啉)苯(PBOX)或者1,4-双(2-噁唑啉)苯(PBOX)和己二酰双己内酰胺(ABC)作为扩链剂对PrePEA进行扩链,得到特性黏度在0.39~0.47dL/g之间的聚酯酰胺。并利用¹H-NMR、FT-IR、DSC、WAXS对扩链后聚酯酰胺的结构、热性能以及力学性能进行了表征。结果表明,酰胺摩尔分数为20%的预聚体经PBOX扩链后熔点为101.09℃,拉伸强度为11.16MPa,断裂伸长率为1071.22%;酰胺摩尔分数为40%的预聚体经PBOX和ABC双扩链剂扩链的熔点是159.92℃,拉伸强度为22.42MPa,断裂伸长率为710.09%。     

手性β-氨基醇催化的芳香醛对映选择性炔化反应

 手性β-氨基醇是不对称催化反应中应用最为广泛的手性配体之一.以L-苯丙氨酸为原料简捷合成的手性β-氨基醇L^*为手性配体,对不同取代芳香醛的对映选择性炔化反应进行了研究,结果表明其对该反应具有一定的不对称催化活性,光学收率(e.e值)最高达78.9%.     

合成C_1～C_(10)脂肪族羧酸2-苯氧乙酯的新方法

C_1～C_(10)酯肪族羧酸2-苯氧乙酯具有茉莉、玫瑰、水果等香气,其中异丁酸苯氧基乙酯具有令人愉快的蜂密、玫瑰、果香型香气特征,它的化学性质稳定,适用于调配各种食品香精和皂用及洗涤剂和香精等。文献[4]上曾以浓硫酸为催化剂,或以离子交换树脂KY-1,在碱金属硫酸盐存在下进行酯化反应。1987年我们报导了Fe_2(SO_4)_3。     

酮型二苯并-14-冠-4聚合物的合成及表征

介绍了脂肪族二元酸与二苯并-14-冠-4在多聚磷酸(PPA)催化下发生的缩聚反应,在此基础上合成了酮型冠醚聚合物.并用红外光谱、元素分析、核磁共振、热分析等手段对所合成的化合物进行了表征.