Cardiolipin, the heart of mitochondrial metabolism

Cardiolipin is a unique phospholipid, which is almost exclusively localized in the mitochondrial inner membrane where it is synthesized from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. After primary synthesis, the mature acyl chain composition of cardiolipin is achieved by at least two remodeling mechanisms. In the mitochondrial membrane cardiolipin plays an important role in energy metabolism, mainly by providing stability for the individual enzymes and enzyme complexes involved in energy production. Moreover, cardiolipin is involved in different stages of the mitochondrial apoptotic process and in mitochondrial membrane dynamics. Cardiolipin alterations have been described in various pathological conditions. Patients suffering from Barth syndrome have an altered cardiolipin homeostasis caused by a primary deficiency in cardiolipin remodeling. Alterations in cardiolipin content or composition have also been reported in more frequent diseases such as diabetes and heart failure. In this review we provide an overview of cardiolipin metabolism, function and its role in different pathological states. Received 16 January 2008; received after revision 26 February 2008; accepted 26 March 2008     

The three-fingered protein domain of the human genome

Extracellular domains of some cellular receptors expressed in the organisms at different levels of development belong to three-fingered protein (TFP) fold. The Homo sapiens genome encodes at least 45 genes containing from one to three TFP domains (TFPDs), namely diverse paralogues of the Ly6 gene, CD59 and the receptors of activins, bone morphogenetic proteins, Mullerian inhibiting substance and transforming growth factor-β. C4.4a and urokinase/plasminogen activatory receptor contain two and three TFPD repeats, respectively. These diverse proteins have a low overall sequence similarity with each other and their hydrophobicity levels vary to a considerable degree. It is suggested that sequence differentiation within the TFPD led to distinct groups of proteins whose attributes were optimized to fit both the physicochemical properties specific to their functional microenvironment and selective targeting of their highly diversified extracellular cofactors. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users. Received 7 August 2008; accepted 29 August 2008     

大跨平屋盖结构风压分布特性的神经网络模型

影响大跨平屋盖结构风荷载分布特性的因素很复杂，且具有不确定性，仅靠风洞试验难以完整的描述其风荷载分布的整体特性，针对这种情况，本文中提出用改进的BP神经网络和模糊神经网络两种方法来建立反映大跨平屋盖结构风压分布特性的模型，并用试验数据进行了验证．结果表明，这两种模型都能很好的逼近和预测大跨平屋盖结构风压分布的特性，相比之下，改进的BP神经网络稳定性较好，但逼近速度慢，精度也不高；而模糊神经网络由于结合了模糊系统和神经网络的优点，其稳定性好，逼近速度快，且精度高，这表明模糊神经网络方法是预测大跨平屋盖结构风压分布特性的有效途径，在结构风工程中具有广阔的应用前景。     

增强基层部队心理健康教育实效性的对策思考

军人健康的心理是军人思想政治素质、军事业务素质、科学文化素质形成和提高的基础，是生成部队凝聚力、战斗力的重要因素。开展心理健康教育是促进军人心理健康的主要手段，文中从理念、目标、内容、方法、形式五个方面分析了增强基层部队心理健康教育实效性需要关注的几个问题。     

强化德育渗透理念,提高《纲要》教学实效性

《纲要》作为新开设的高校政治理论课,兼具思想政治教育的主题功能和历史专业的学科背景,要取得良好的教学效果,真正达到教学目的,就必须切实提高其课程教学的实效性。这就需要探索出一套有效的教学方法和路径,在教育理念上以凸显爱国主义为主题,在教学取向中以道德渗透为目的,在教学过程中以方法创新为手段,在教学环节上以实践跟进为保障。     

太阳温度与能源的测算和寿命分析

对太阳表面温度利用多种方法进行测算，并按温度随深度递增规律，分析太阳中心温度，利用太阳中心区物理条件和化学成分研究太阳能量的产生和质量的消耗，并对太阳寿命进行推论分析．     

遗传毒物对秀丽隐杆线虫(Caenorhabditis elegans)寿命的影响

研究了丝裂霉素C,噻替哌和环磷酰胺对秀丽隐杆线虫(C.elegans)温度敏感突变型DH26衰老的影响。结果表明,除极高浓度(100μg/ml)的丝裂霉素C能缩短线虫寿命外,其余对寿命均无影响。     

真应力应变曲线的自动测试

介绍材料力学实验中的微机自动测试系统及其测试:真应力应变全程曲线和屈服极限σ_s,强度极限σ_b、延伸率δ、颈缩率ψ的自动测试方法。并结合实例说明了软件和横向位移传感器的结构设计。     

在span20存在下孔雀石绿与金的显色反应研究

研究了在ｓｐａｎ２０存在下孔雀石绿－金的显色反应。结果表明，金－孔雀石绿－ｓｐａｎ２０的三元络合物的表观摩尔吸光系数比孔雀石绿－金的大７～８倍，可达５．０×１０５Ｌ·ｍｏｌ－１·ｃｍ－１。金含量在（０～１２）μｇ／１０ｍｌ范围内符合比尔定律。     

双跨连拱隧道掘进及初期支护工艺介绍

结合客塘双跨连拱隧道的施工经验,阐述高速公路双跨连拱隧道应用三导洞法掘进及初期支护的施工工艺,以及监控量测在施工中的应用。