Structural Prediction of Membrane Protein: Application to Known Structures

Membrane proteins are embedded in the lipid bilayer,which creates a suitable environment for their actions. It is important to decide which tpye it belongs to because it is closely relevant to its biological fumction and its interaction process with other molecules in a biological system. Membrane proteins have different types. The function of a membrane protein is closely correlated with the type it belongs to. In this study, on the basis of the concept of pseudo amino acid (PseAA) composition originally introduced by Chou, the value of approximate entropy (ApEn) of the query membrane protein was used to integrate the complementary information. By fusing fifteen powerful individual fuzzy K-nearest neighbor (FKNN) classifiers, an ensemble classifier was presented.Each basic classifier was trained in PseAA composition of membrane protein sequences with different parameters. The results of experiments demonstrate it is efficient for the structural prediction of membrane proteins.     

有机合成中杂多酸催化应用研究十九年

简要概括了作民在课题组１９年间有机合成中以杂多酸为催化剂所开展的研究成果，其中包括从Ｃ４混合物中异丁烯选择低聚，低级烯烃与醋酸的直接酯化，由马豆醛制造喃、杂多酸为改性剂的骨架镍和骨架钴上不饱和醛选择加氢制不饱和醇等研究成果，拓宽了杂多酸的催化研究领域。     

空气氧化法制备胡椒酸的研究

黄樟油素于乙酸溶剂中，在ＣｏＢｒ系列催化剂的催化下，被空气氧化成胡椒酸，总收率达到７６．０％．     

Synthesis and characterization of amphiphilc block copolymer poly(methyl acrylic acid)-block-polytetrahydrofuran

Under the specially designated condition the polymerization of both tetrahydrofuran (THF) andtert-butyl methacrylate (tBMA) is a living one. The diblock copolymer, poly(tert-butyl methacrylate)-block-polytetrahydrofuran (PtBMA-b-PTHF), was successfully synthesized by means of the coupling reaction of living cationic PTHF⁺, SbF₆ with living anionic PtBMA^-, Li⁺. LiCI, which has a beneficial effect on the molecular weight distribution (MWD) in the anionic polymerization of (meth)acrylates, hinders the coupling reaction of living chains and cannot be used in the preparation of tBMA precursor. The hydrolysis of the aforementioned diblock copolymer under acid condition results in the amphiphilic diblock copolymer, i.e. poly(methy1 acrylic acid)-block-polytetrahydrofuran (PMAA-b-PTHF). The diblock copolymers were characterized with GPC and IR.     

生物高分子聚乳酸的合成研究

本文阐述了生物可降解聚乳酸材料的合成原理与合成方法。     

氧化异烟酸铜 (Ⅱ )配合物的晶体结构分析(英文)

在二水氧化异烟酸铜配合物中，铜原子分别与异烟酸中的两个氧原子和两个水分子中的氧原子按反式结构形成四配位体，配位几何构形是平面正方形结构， Cu－ O键长位于 1. 942(3)和 1. 945(2)之间.     

新型石油产品酸值(度)在线分析仪的研制与应用

针对石油组份及结构的变化，采用基于改进的红外光谱技术及先进的计算机控制技术，研制了适用于炼油厂测量石油产品及其中间产品中有机酸的在线智能光谱分析仪，经一年的工业现场运行表明该种仪表具有运行稳定可靠、分析快速准确和维护操作简便的优点．     

对酶特性实验方法的改进

改进后的酶特性实验方法，设计更合理，结果更准确。     

对二茂铁基苯甲酸的合成和表征

以对－氨基苯甲酸为原料与亚硝酸钠和盐酸在低温下反应，制备出对－氨基苯甲酸的重氮盐， 再让其与二茂铁（摩尔比 1∶ 1）在低温和相转移催化剂的存在下反应，再由水蒸气蒸馏分离，合成出对－二茂铁基苯甲酸。通过多步实验确定出最佳合成条件，并用元素分析、红外光谱、质谱对产物进行表征。     

以醋酐和硫磺为催化剂的醋酸氯化合成氯乙酸

对以醋酐为催化剂和以硫磺为催化剂的醋酸氯化合成氯乙酸的优劣进行了比较研究。得出，以硫磺为催化剂时，乙酰氯是逐渐释放的，其逃逸速度慢，氯化反应效果好，催化剂用量小，生产成本低，优于以醋酐为催化剂的氯化反应。