Pharmacodynamic profile of CQP 201-403, a novel 8α-amino-ergoline

Summary The profile of action in animals of CQP 201-403, a novel 8-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel^®).In memory of Dr Annemarie Closse, who died 14 June 1987.     

Metabolism of 3β-hydroxycholest-5-en-26-oic acid in hamsters

Summary Metabolism of 26-hydroxycholesterol to 3-hydroxychol-5-en-24-oic acid and other C24-bile acids has been expected to occur by way of 3-hydroxycholest-5-en-26-oic acid in studies in vitro. 3-Hydroxycholest-5-en-26-oic acid was infused intravenously into bile fistula hamsters and the following C24-bile acids were identified: 3-hydroxychol-5-en-24-oic acid, lithocholic acid, chenodeoxycholic acid, and a small amount of cholic acid.     

硅压阻式传感器与AD7705芯片在压力测量中的应用

介绍一种新型测量压力的元件——硅半导体压阻式传感器，并以MPX2100压阻式传感器为例，配合AD7705芯片构成压力测量系统，阐述压力测量系统的工作原理，说明系统的软、硬件设计方法．     

(−)-Epigallocatechin gallate,a polyphenolic tea antioxidant,inhibits peroxynitritemediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine

Reaction with peroxynitrite at pH 7.4 and 37°C was found to increase the 8-oxodeoxyguanosine levels in calf thymus DNA 35-38-fold. This oxidation of deoxyguanosine, as well as the peroxynitrite-mediated nitration of tyrosine to 3-nitrotyrosine, was significantly inhibited by ascorbic acid, glutathione and (–)-epigallocatechin gallate, a polyphenolic antioxidant present in tea. For 50% inhibition of the oxidation of deoxyguanosine to 8-oxodeoxyguanosine, 1.1, 7.6 of 0.25 mM ascorbate, glutathione or (–)-epigallocatechin gallate, respectively, was required. For 50% inhibition of tyrosine nitration, the respective concentrations were 1.4, 4.6 or 0.11 mM. Thus, (–)-epigallocatechin gallate is a significantly better inhibitor of both reactions than either ascorbate or glutathione. Reaction of (–)-epigallocatechin gallate with peroxynitrite alone resulted in the formation of a number of products. Ultraviolet spectra of two of these suggest that the tea polyphenol and/or its oxidation products are nitrated by peroxynitrite.     

多功能时间控制器设计

本文介绍通用可编程时间控制器的单片机实现，介绍其硬件及软件设计。     

基于DSP-MCU数字化焊接电源系统的设计

采用TMS320F240数字信号处理器和80C196KC单片机设计多功能IGBT逆变焊接电源双机控制系统.其中,TMS320F240主要用于焊接参数的采样、控制算法的运算;80C196KC用于完成人机接口的功能,包括键盘和显示,与上位机的通信等.设计中人机界面采用液晶显示.系统设计的关键是双机之间的通信技术,为了确保通信的可靠及快速性采用双口RAMIDT7005来完成.数字PWM控制单元采用复杂可编程逻辑器件(CPLD)完成,整个系统中所有逻辑控制也由此芯片来完成,实现了多功能焊机的全数字化控制.     

单片机仿真实验的探讨与研究

本文介绍了传统的单片机实验方法和利用Proteus（http：／／www．labcenter.co．uk）软件进行单片机仿真实验。包括从元器件的选择、电路的连结、源程序的输入及调试、仿真结果的输出，并比较了各自的特点。     

tRNase Z: the end is not in sight

Although the enzyme tRNase Z has only recently been isolated, a plethora of data has already been acquired concerning the enzyme. tRNase Z is the endonuclease that catalyzes the removal of the tRNA 3′ trailer, yielding the mature tRNA 3′ end ready for CCA addition and aminoacylation. Another substrate cleaved by tRNase Z is the small chromogenic phosphodiester bis(p-nitrophenyl)phosphate (bpNPP), which is the smallest tRNase Z substrate known so far. Hitherto the biological function as tRNA 3′-end processing enzyme has been shown only in one prokaryotic and one eukaryotic organism, respectively. This review summarizes the present information concerning the two tRNase Z substrates pre-tRNA and bpNPP, as well as the metal requirements of tRNase Z enzymes. Received 29 March 2007; received after revision 15 May 2007; accepted 21 May 2007     

可编程的VXI总线消息基接口芯片设计与实现

本文介绍了用大规模可编程逻辑器件设计和实现ＶＸＩ总线消息基接口芯片。该接口芯片具有中断ＲＯＲＡ、Ａ１６／Ｄ１６、Ａ２４／Ｄ３２及块传输能力,传输速率高达２０ＭＢ／ｓ。由于采用可重配置可编程逻辑器件,故很易实现ＶＸＩ总线Ａ３２／Ｄ３２的能力。     

Positive Study on the Risks of Investment

1. INTRODUCTIONWhen studying the risks in securities investment, we usually adopt the CAPM [11 model andcategorize the risks into systematic risks and non-systematic risks according to their naturesand the measuremellts taken to deal with the risks. Systematic risks called big market risksor macrthrisks, are related to the whole market, will influence all the stocks on the marketand can not be resolved. Non-systematic risks are risks unique to a company or an industryti. e., risks of the…